Controversies in the Treatment of Peripheral T-cell Lymphoma.

Peripheral T-cell lymphomas are a heterogeneous group of rare diseases with an aggressive behavior and dismal prognosis. Their classification is complex and still evolving, and several biomolecular markers now help refine the prognosis of specific disease entities, although still have limited impact in tailoring the treatment. First-line treatment strategies can cure only a minority of patients and relapsed-refractory disease still represents the major cause of failure. Frontline autologous transplantation may have an impact in the consolidation of response; however, its role is still questioned as far as complete responses obtained after induction chemotherapy are concerned. Newer drugs are now being evaluated in clinical trials, but effective salvage strategies for those who experience treatment failures are lacking. Here we review and discuss the most controversial aspects of diagnosis and treatment of peripheral T-cell lymphomas

Discovery of a flux-related change of the cyclotron line energy in Her X-1

We present the results of ten years of repeated measurements of the Cyclotron Resonance Scattering Feature (CRSF) in the spectrum of the binary X-ray pulsar Her X-1 and report the discovery of a positive correlation of the centroid energy of this absorption feature in pulse phase averaged spectra with source luminosity.Our results are based on a uniform analysis of observations bythe RXTE satellite from 1996 to 2005, using sufficiently long observations of 12 individual 35-day Main-On states of the source. The mean centroid energy E_c of the CRSF in pulse phase averaged spectra of Her X-1 during this time is around 40 keV, with significant variations from one Main-On state to the next. We find that the centroid energy of the CRSF in Her X-1 changes by ~5% in energy for a factor of 2 in luminosity. The correlation is positive, contrary to what is observed in some high luminosity transient pulsars. Our finding is the first significant measurement of a positive correlation between E_c and luminosity in any X-ray pulsar. We suggest that this behaviour is expected in the case of sub-Eddington accretion and present a calculation of a quantitative estimate, which is very consistent with the effect observed in Her X-1.We urge that Her X-1 is regularly monitored further and that other X-ray pulsars are investigated for a similar behaviour.Comment: 4 pages, 2 figures, accepted by A&A Letter

Rotating dust solutions of Einstein's equations with 3-dimensional symmetry groups, Part 3: All Killing fields linearly independent of u^{\alpha} and w^{\alpha}

This is the third and last part of a series of 3 papers. Using the same method and the same coordinates as in parts 1 and 2, rotating dust solutions of Einstein's equations are investigated that possess 3-dimensional symmetry groups, under the assumption that each of the Killing vectors is linearly independent of velocity $u^{\alpha}$ and rotation $w^{\alpha}$ at every point of the spacetime region under consideration. The Killing fields are found and the Killing equations are solved for the components of the metric tensor in every case that arises. No progress was made with the Einstein equations in any of the cases, and no previously known solutions were identified. A brief overview of literature on solutions with rotating sources is given.Comment: One missing piece, signaled after eq. (10.7), is added after (10.21). List of corrections: In (3.7) wrong subscript in vorticity; In (3.10) wrong subscript in last term of g_{23}; In (4.23) wrong formulae for g_{12} and g_{22}; In (7.17) missing factor in velocity; In (7.18) one wrong factor in g_{22}; In (10.9) factor in vorticity; In (10.15) - (10.20) y_0 = 0; In (10.20) wrong second term in y. The rewriting typos did not influence result

Nonideal strongly magnetized plasmas of neutron stars and their electromagnetic radiation

We study the equation of state, polarization and radiation properties for nonideal, strongly magnetized plasmas which compose outer envelopes of magnetic neutron stars. Detailed calculations are performed for partially ionized hydrogen atmospheres and for condensed hydrogen or iron surfaces of these stars. This is a companion paper to astro-ph/0511803Comment: 7 pages, 3 figures. Invited topical talk at Strongly Coupled Coulomb Systems (Moscow, June 20-25, 2005); to appear in Journal of Physics

Equation of State of Nuclear Matter at high baryon density

A central issue in the theory of astrophysical compact objects and heavy ion reactions at intermediate and relativistic energies is the Nuclear Equation of State (EoS). On one hand, the large and expanding set of experimental and observational data is expected to constrain the behaviour of the nuclear EoS, especially at density above saturation, where it is directly linked to fundamental processes which can occur in dense matter. On the other hand, theoretical predictions for the EoS at high density can be challenged by the phenomenological findings. In this topical review paper we present the many-body theory of nuclear matter as developed along different years and with different methods. Only nucleonic degrees of freedom are considered. We compare the different methods at formal level, as well as the final EoS calculated within each one of the considered many-body schemes. The outcome of this analysis should help in restricting the uncertainty of the theoretical predictions for the nuclear EoS.Comment: 51 pages, to appear in J. Phys. G as Topical Revie

Constraining properties of neutron stars with heavy-ion reactions in terrestrial laboratories

Heavy-ion reactions provide a unique means to investigate the equation of state (EOS) of neutron-rich nuclear matter, especially the density dependence of the nuclear symmetry energy $E_{sym}(\rho)$. The latter plays an important role in understanding many key issues in both nuclear physics and astrophysics. Recent analyses of heavy-ion reactions have already put a stringent constraint on the $E_{sym}(\rho)$ around the saturation density. This subsequently allowed us to constrain significantly the radii and cooling mechanisms of neutron stars as well as the possible changing rate of the gravitational constant G.Comment: 6 pages. Talk given at the Nuclear Physics in Astrophysics III, Dresden, Germany, March 26-31, 2007. To appear in a special volume of J. of Phys.

A Large, Uniform Sample of X-Ray-emitting AGNs: Selection Approach and an Initial Catalog from the ROSAT All-Sky and Sloan Digital Sky Surveys

Many open questions in X-ray astronomy are limited by the relatively small number of objects in uniform optically identified and observed samples, especially when rare subclasses are considered or when subsets are isolated to search for evolution or correlations between wavebands. We describe the initial results of a new program aimed to ultimately yield ~10⁴ fully characterized X-ray source identifications—a sample about an order of magnitude larger than earlier efforts. The technique is detailed and employs X-ray data from the ROSAT All-Sky Survey (RASS) and optical imaging and spectroscopic follow-up from the Sloan Digital Sky Survey (SDSS); these two surveys prove to be serendipitously very well matched in sensitivity. As part of the SDSS software pipelines, optical objects in the SDSS photometric catalogs are automatically positionally cross-correlated with RASS X-ray sources. Then priorities for follow-on SDSS optical spectra of candidate counterparts are automatically assigned using an algorithm based on the known ratios of f_x/f_opt for various classes of X-ray emitters at typical RASS fluxes of ~10⁻¹³ ergs cm⁻² s⁻¹. SDSS photometric parameters for optical morphology, magnitude, and colors, plus FIRST radio information, serve as proxies for object class. Initial application of this approach to RASS/SDSS data from 1400 deg² of sky provides a catalog of more than 1200 spectroscopically confirmed quasars and other AGNs that are probable RASS identifications. Most of these are new identifications, and only a few percent of the AGN counterparts are likely to be random superpositions. The magnitude and redshift ranges of the counterparts are very broad, extending over 15 < m < 21 and 0.03 < z < 3.6, respectively. Although most identifications are quasars and Seyfert 1 galaxies, a variety of other AGN subclasses are also sampled. Substantial numbers of rare AGN types are found, including more than 130 narrow-line Seyfert 1 galaxies and 45 BL Lac candidates. These early results already provide a very sizable set of source identifications, demonstrate the utility of the sample in multiwaveband investigations, and show the capability of the joint RASS/SDSS approach to efficiently proceed toward the largest homogeneously selected/observed sample of X-ray–emitting quasars and other kinds of AGNs

Shear-free, Irrotational, Geodesic, Anisotropic Fluid Cosmologies

General relativistic anisotropic fluid models whose fluid flow lines form a shear-free, irrotational, geodesic timelike congruence are examined. These models are of Petrov type D, and are assumed to have zero heat flux and an anisotropic stress tensor that possesses two distinct non-zero eigenvalues. Some general results concerning the form of the metric and the stress-tensor for these models are established. Furthermore, if the energy density and the isotropic pressure, as measured by a comoving observer, satisfy an equation of state of the form $p = p(\mu)$, with $\frac{dp}{d\mu} \neq -\frac{1}{3}$, then these spacetimes admit a foliation by spacelike hypersurfaces of constant Ricci scalar. In addition, models for which both the energy density and the anisotropic pressures only depend on time are investigated; both spatially homogeneous and spatially inhomogeneous models are found. A classification of these models is undertaken. Also, a particular class of anisotropic fluid models which are simple generalizations of the homogeneous isotropic cosmological models is studied.Comment: 13 pages LaTe

Hydrogen molecule in a magnetic field: The lowest states of the Pi manifold and the global ground state of the parallel configuration

The electronic structure of the hydrogen molecule in a magnetic field is investigated for parallel internuclear and magnetic field axes. The lowest states of the $\Pi$ manifold are studied for spin singlet and triplet$(M_s = -1)$ as well as gerade and ungerade parity for a broad range of field strengths $0 \leq B \leq 100 a.u.$ For both states with gerade parity we observe a monotonous decrease in the dissociation energy with increasing field strength up to $B = 0.1 a.u.$ and metastable states with respect to the dissociation into two H atoms occur for a certain range of field strengths. For both states with ungerade parity we observe a strong increase in the dissociation energy with increasing field strength above some critical field strength $B_c$. As a major result we determine the transition field strengths for the crossings among the lowest $^1\Sigma_g$, $^3\Sigma_u$ and $^3\Pi_u$ states. The global ground state for $B \lesssim 0.18 a.u.$ is the strongly bound $^1\Sigma_g$ state. The crossings of the $^1\Sigma_g$ with the $^3\Sigma_u$ and $^3\Pi_u$ state occur at $B \approx 0.18$ and $B \approx0.39 a.u.$, respectively. The transition between the $^3\Sigma_u$ and $^3\Pi_u$ state occurs at $B \approx 12.3 a.u.$ Therefore, the global ground state of the hydrogen molecule for the parallel configuration is the unbound $^3\Sigma_u$ state for $0.18 \lesssim B \lesssim 12.3 a.u.$ The ground state for $B \gtrsim 12.3 a.u.$ is the strongly bound $^3\Pi_u$ state. This result is of great relevance to the chemistry in the atmospheres of magnetic white dwarfs and neutron stars.Comment: submitted to Physical Review