Trauma Reactions in Social Work Students: Increasing Awareness of PTSD and Self-Care Through the PTSD Coach Application

Research supports that social work (SW) students may experience Post Traumatic Stress Disorder (PTSD) symptoms in response to course material, pedagogical practices, field practicum experiences, racial trauma, lack of PTSD knowledge and decreased self-care awareness. As a result, a neurological impact on their limbic system causes the frontal lobe to shut down, activating the autonomic nervous system’s acute stress reaction to SW content resembling traumatic events (triggers) in a fight, flight, or freeze response. Research indicates that trauma reactions are a barrier to encoding new memories and an impediment to learning pertinent SW information. A substantial body of research indicates that PTSD education and self-care awareness reduce PTSD symptoms; however, self-care practice is often underutilized. This study aimed to a) increase student psychoeducation of PTSD, and b) increase student self-care awareness through the Learn and Manage Symptoms sections of the PTSD Coach application. The evidence-based, widely used app was created by the Department of Veterans Affairs and is proven to reduce PTSD symptoms while increasing self-care and PTSD knowledge. During the eight-week study, a ten-item pre-test, and post-test comparison assessed SW students’ PTSD knowledge (fourteen participants) and self-care awareness (twelve participants). During the second phase of the study, a weekly two-item Likert scale asked students if they used the app and if so, how helpful was it in reducing their distress. The study was inconclusive in drawing statistically significant conclusions due to the small sample size. Insignificant improvements in post-test scores and declining participation indicate that students failed to use the PTSD Coach app. However, results slightly show a correlation between using the PTSD app and reducing SW students’ distress. Future efforts should focus on increasing students’ motivation to practice self-care by incorporating assignments and lessons into the SW course curriculum. Such content would act as a reminder to SW students that self-care a) mitigates the emotional and cognitive effects of trauma and b) strengthens their mental and physical well-being

Bi-stability of mixed states in neural network storing hierarchical patterns

We discuss the properties of equilibrium states in an autoassociative memory model storing hierarchically correlated patterns (hereafter, hierarchical patterns). We will show that symmetric mixed states (hereafter, mixed states) are bi-stable on the associative memory model storing the hierarchical patterns in a region of the ferromagnetic phase. This means that the first-order transition occurs in this ferromagnetic phase. We treat these contents with a statistical mechanical method (SCSNA) and by computer simulation. Finally, we discuss a physiological implication of this model. Sugase et al. analyzed the time-course of the information carried by the firing of face-responsive neurons in the inferior temporal cortex. We also discuss the relation between the theoretical results and the physiological experiments of Sugase et al.Comment: 18 pages, 6 figure

Stochastic transitions of attractors in associative memory models with correlated noise

We investigate dynamics of recurrent neural networks with correlated noise to analyze the noise's effect. The mechanism of correlated firing has been analyzed in various models, but its functional roles have not been discussed in sufficient detail. Aoyagi and Aoki have shown that the state transition of a network is invoked by synchronous spikes. We introduce two types of noise to each neuron: thermal independent noise and correlated noise. Due to the effects of correlated noise, the correlation between neural inputs cannot be ignored, so the behavior of the network has sample dependence. We discuss two types of associative memory models: one with auto- and weak cross-correlation connections and one with hierarchically correlated patterns. The former is similar in structure to Aoyagi and Aoki's model. We show that stochastic transition can be presented by correlated rather than thermal noise. In the latter, we show stochastic transition from a memory state to a mixture state using correlated noise. To analyze the stochastic transitions, we derive a macroscopic dynamic description as a recurrence relation form of a probability density function when the correlated noise exists. Computer simulations agree with theoretical results.Comment: 21 page

Asymptomatic Left Ventricle Systolic Dysfunction

Heart failure is a common debilitating illness, associated with significant morbidity and mortality, rehospitalisation and societal costs. Current guidelines and position statements emphasise the management of patients with overt symptomatic disease, but the increasing prevalence of congestive heart failure underscores the need to identify and manage patients with early left ventricular dysfunction prior to symptom onset. Asymptomatic left ventricular systolic dysfunction (ALVSD), classified as stage B heart failure, is defined as depressed left ventricular systolic function in the absence of clinical heart failure. Early initiation of therapies in patients with presumed ALVSD has been shown to lead to better outcomes. In this article, the authors clarify issues surrounding the definition and natural history of ALVSD, outline clinical tools that may be of value in identifying patients with ALVSD and highlight potential opportunities for future investigations to better address aspects of our understanding of this complex syndrome

Scrutinizing LSP Dark Matter at the LHC

We show that LHC experiments might well be able to determine all the parameters required for a prediction of the present density of thermal LSP relics from the Big Bang era. If the LSP is an almost pure bino we usually only need to determine its mass and the mass of the SU(2) singlet sleptons. This information can be obtained by reconstructing the cascade $\tilde{q}_L \to \tilde{\chi}_2^0 q \to \tilde{\ell}_R \ell q \to \tilde{\chi}_1^0 \ell^+ \ell^- q$. The only requirement is that $m_{\tilde{\ell}_R} < m_{\tilde{\chi}_2^0}$, which is true for most of the cosmologically interesting parameter space. If the LSP has a significant higgsino component, its predicted thermal relic density is smaller than for an equal--mass bino. We show that in this case squark decays also produce significant numbers of $\tilde{\chi}_4^0$ and $\tilde{\chi}_2^\pm$. Reconstructing the corresponding decay cascades then allows to determine the higgsino component of the LSP

Systematic phenome analysis of Escherichia coli multiple-knockout mutants reveals hidden reactions in central carbon metabolism

Central carbon metabolism is a basic and exhaustively analyzed pathway. However, the intrinsic robustness of the pathway might still conceal uncharacterized reactions. To test this hypothesis, we constructed systematic multiple-knockout mutants involved in central carbon catabolism in Escherichia coli and tested their growth under 12 different nutrient conditions. Differences between in silico predictions and experimental growth indicated that unreported reactions existed within this extensively analyzed metabolic network. These putative reactions were then confirmed by metabolome analysis and in vitro enzymatic assays. Novel reactions regarding the breakdown of sedoheptulose-7-phosphate to erythrose-4-phosphate and dihydroxyacetone phosphate were observed in transaldolase-deficient mutants, without any noticeable changes in gene expression. These reactions, triggered by an accumulation of sedoheptulose-7-phosphate, were catalyzed by the universally conserved glycolytic enzymes ATP-dependent phosphofructokinase and aldolase. The emergence of an alternative pathway not requiring any changes in gene expression, but rather relying on the accumulation of an intermediate metabolite may be a novel mechanism mediating the robustness of these metabolic networks

The coordination of cell growth during fission yeast mating requires Ras1-GTP hydrolysis

The spatial and temporal control of polarity is fundamental to the survival of all organisms. Cells define their polarity using highly conserved mechanisms that frequently rely upon the action of small GTPases, such as Ras and Cdc42. Schizosaccharomyces pombe is an ideal system with which to study the control of cell polarity since it grows from defined tips using Cdc42-mediated actin remodeling. Here we have investigated the importance of Ras1-GTPase activity for the coordination of polarized cell growth during fission yeast mating. Following pheromone stimulation, Ras1 regulates both a MAPK cascade and the activity of Cdc42 to enable uni-directional cell growth towards a potential mating partner. Like all GTPases, when bound to GTP, Ras1 adopts an active conformation returning to an inactive state upon GTP-hydrolysis, a process accelerated through interaction with negative regulators such as GAPs. Here we show that, at low levels of pheromone stimulation, loss of negative regulation of Ras1 increases signal transduction via the MAPK cascade. However, at the higher concentrations observed during mating, hyperactive Ras1 mutations promote cell death. We demonstrate that these cells die due to their failure to coordinate active Cdc42 into a single growth zone resulting in disorganized actin deposition and unsustainable elongation from multiple tips. These results provide a striking demonstration that the deactivation stage of Ras signaling is fundamentally important in modulating cell polarity

Sexual Risk Behaviors for HIV/AIDS in Chuuk State, Micronesia: The Case for HIV Prevention in Vulnerable Remote Populations

BACKGROUND: After the first two cases of locally-acquired HIV infection were recognized in Chuuk State, Federated States of Micronesia (FSM), a public health response was initiated. The purpose of the response was to assess the need for HIV education and prevention services, to develop recommendations for controlling further spread of HIV in Chuuk, and to initiate some of the prevention measures. METHODOLOGY/PRINCIPAL FINDINGS: A public health team conducted a survey and rapid HIV testing among a sample of residents on the outer islands in Chuuk. Local public health officials conducted contact tracing and testing of sex partners of the two locally-acquired cases of HIV infection. A total of 333 persons completed the survey. The majority knew that HIV is transmitted through unprotected sexual contact (81%), injection drug use (61%), or blood transfusion (64%). Sexual activity in the past 12 months was reported among 159 participants, including 90 females and 69 males. Compared to women, men were more likely to have had multiple sex partners, to have been drunk during sex, but less likely to have used a condom in the past 12 months. The two men with locally acquired HIV infection had unprotected anal sex with a third Chuukese man who likely contracted HIV while outside of Chuuk. All 370 persons who received voluntary, confidential HIV counseling and testing had HIV negative test results. CONCLUSIONS/SIGNIFICANCE: Despite the low HIV seroprevalence, risky sexual behaviors in this small isolated population raise concerns about the potential for rapid spread of HIV. The lack of knowledge about risks, along with stigmatizing attitudes towards persons infected with HIV and high risk sexual behaviors indicate the need for resources to be directed toward HIV prevention in Chuuk and on other Pacific Islands