Universal design approach to analysis of physical environment for users with multiple sclerosis

The concept of Universal Design aims for the utilization of every product and environment for every individual without the need for further adaptation. The frequent occurrence of Multiple Sclerosis (MS) in societies has necessitated a more innovative and exploratory approach to the field of design. Many of the products and built environments encountered by individuals with MS in their daily lives fall short in terms of meeting safety and accessibility needs. It is essential to establish the correct design approach so that users with MS can meet their needs easily and safely without depending on others. In this research, the problems encountered by users with MS in their residences were evaluated within the framework of Universal Design principles, and design recommendations were stated using a sample case in Turkey. Throughout the study, accessibility challenges, mobility, fatigue and balance problems, vision and lighting conditions, climatization and noise sensitivity, and psychological issues were primarily considered. The residence of the sample user with MS was examined in detail, and an in-depth interview was conducted during the research. The difficulties and life routines of the user with MS were observed and identified. Home design solutions associated with Universal Design principles were represented so that the users with MS have safe and accessible housing regarding their physiological and psychological conditions. The highlighted proposals may contribute to architectural design to make modifications for comfortable and safe housing in related cases having similar symptoms with MS. Future research can benefit from these findings and proposals to provide innovative approaches, develop policies, and conduct interdisciplinary studies on related design issues.Peer Reviewe

Prostat adenokarsinomlarında IMP-3 ekspresyonunun araştırılması

Objective: Prostate cancer is the second most common cause of male cancer deaths after lung cancer in developed countries. The prognostic factors currently identified for prostate carcinoma include preoperative serum PSA, TNM staging system, histological grade and surgical margin status and are composed of the clinically most important and useful parameters. However, all the markers studied have not been applied in clinical practice. The oncofetal protein Insulin-Like Growth Factor II has been demonstrated to be associated with aggressive tumor behavior in many organs including urothelial tumors and renal cell carcinoma. Our aim was to investigate the expression status of Insulin-Like Growth Factor II in benign prostate glands, high grade PIN and prostate adenocarcinoma, and to determine the role of Insulin-Like Growth Factor II in pathogenesis of prostate adenocarcinoma. Material and Method: A total of 70 prostate adenocarcinoma cases accompanied by high grade PIN and benign prostate glands were evaluated by immunohistochemistry for the expression of Insulin-Like Growth Factor II. Results: Insulin-Like Growth Factor II expression was not seen in any of the 70 prostate adenocarcinoma and high grade PIN cases and benign prostate glands. Conclusion: Although the number of our cases was limited, our results suggested that Insulin-Like Growth Factor II protein expression was not included in the pathogenesis of the prostate adenocarcinomas and Insulin-Like Growth Factor II expression status cannot be used for diagnosis of prostate adenocarcinomas

FOXA1 is associated with high tumor grade, myometrial invasion and lymph node invasion in endometrial endometrioid carcinoma

Objectives: FOXA1 expression has been demonstrated in several hormone-dependent cancers. However, data are limited concerning the role of FOXA1 in endometrial cancers. The present study aimed to investigate FOXA1 expression via the microarray technique in benign hyperplasia, endometrial intraepithelial neoplasia, and endometrial endometrioid carcinoma. We also aimed to determine whether there were any associations between FOXA1 expression, tumor grade, myometrial invasion and lymphatic invasion.Material and methods: Paraffin-embedded sections prepared from samples obtained from 114 patients who underwent surgical hysterectomy or curettage were analyzed. Data were retrieved from digitally-stored medical records. Tissue microarrays were prepared from formalin-fixed, paraffin-embedded tissue blocks. Full tumor sections were used for immunohistochemical analysis performed.Results: Carcinomas with nuclear grade 3 had higher FOXA1 values than others, while grade 2 carcinomas also had higher FOXA1 values relative to grade 1 (p < 0.001). FOXA1 values of FIGO stage III carcinomas were significantly higher than others and stage II values were also significantly higher than stage I FOXA1 values (p < 0.001). Patients with myometrial and lymph node invasion had significantly higher FOXA1 values than others (p < 0.001 and p = 0.047, respectively). FOXA1 had 91.30% sensitivity, 63.60% specificity and 77.78% accuracy for predicting the presence of myometrial invasion with a cut-off value of 9.Conclusions: FOXA1 expression is higher in endometrial endometrioid carcinoma compared to benign endometrial hyperplasia or intraepithelial neoplasia. In patients with endometrial endometrioid carcinoma, high FOXA1 expression is associated with high tumor grade, myometrial and lymph node invasion. However, FOXA1 expression is not associated with lymphovascular or cervical invasion

Metematiksel programlamanın istatistikte uygulamaları

TEZ4237Tez (Yüksek Lisans) -- Çukurova Üniversitesi, Adana, 2002.Kaynakça (s. 117-119) var.v, 116 s. ; 30 cm.

Midwifery Education for Academics and Students in the COVID 19 Pandemic.

ABSTRACTAs in almost every field, midwifery education has been seriously affected by the quarantinesthat have developed with the Covid 19 pandemic.According to the International Confederation of Midwives, Global Standards for MidwiferyEducation-2013, there are some rules that must be met. Unfortunately, clinical applications inthe field could not be carried out accordingly.237While many midwifery academics did not invite students to school and clinics to protect themfrom the pandemic, some countries allowed student midwives to work in clinics accompaniedby a guide midwife as a solution.It seems that the epidemic is not over and midwifery education will continue at school and clinicas before. The most important thing to do is to use protective measures (vaccine, mask, glasses,apron, etc.) very well by students, because midwifery is a profession performed by touching thepatient. However, another point to be considered is the protection of the mental health ofstudents and academicians. Because students are under much higher anxiety than before thepandemic. They are afraid of being infected and coming into contact with an infected patient.Among so many problems, another issue to be worried about the most is that midwives whohave not had enough experience are graduated. A dilemma has developed here. Should weappoint midwives, who are much more needed due to the pandemic, to clinics, even if they areinexperienced? Or should we not let them come to work to prevent new mal practices fromhappening?In the future of midwifery education, it seems necessary to continue some courses digitally sothat contact and fatigue can be reduced. More laboratory work should be allocated for clinicalpractice courses. Although small group clinical practice studies take more time, it is thoughtthat the learning in students may be more permanent.In midwifery education with a view to students: Even if it is risky for students to adapt to theclinic under protective measures, it is important to continue clinical practices by reducingworking hours. It is necessary to develop new regulations for graduated midwives anddetermine the clinical orientation process. For this reason, it is thought that it is important thatthey gain clinical experience in the hospital with their guide colleagues.Keywords: Pandemic, midwifery education, orientation, protective measures.</p