Interstellar Extinction Law toward the Galactic Center III: J, H, Ks bands in the 2MASS and the MKO systems, and 3.6, 4.5, 5.8, 8.0 micron in the Spitzer/IRAC system

We have determined interstellar extinction law toward the Galactic center (GC) at the wavelength from 1.2 to 8.0 micron, using point sources detected in the IRSF/SIRIUS near-infrared survey and those in the 2MASS and Spitzer/IRAC/GLIMPSE II catalogs. The central region |l| < 3deg and |b| < 1deg has been surveyed in the J, H and Ks bands with the IRSF telescope and the SIRIUS camera whose filters are similar to the Mauna Kea Observatories (MKO) near-infrared photometric system. Combined with the GLIMPSE II point source catalog, we made Ks versus (Ks - lambda) color-magnitude diagrams where lambda = 3.6, 4.5, 5.8, and 8.0 micron. The Ks magnitudes of bulge red clump stars and the (Ks - lambda) colors of red giant branches are used as a tracer of the reddening vector in the color-magnitude diagrams. From these magnitudes and colors, we have obtained the ratios of total to selective extinction A(Ks)/E(Ks-lambda) for the four IRAC bands. Combined with A(lambda)/A(Ks) for the J and H bands derived by Nishiyama et al., we obtain A(J):A(H):A(Ks):A([3.6]):A([4.5]):A([5.8]):A([8.0])=3.02:1.73:1:0.50:0.39:0.36:0.43 for the line of sight toward the GC. This confirms the flattening of the extinction curve at lambda > 3 micron from a simple extrapolation of the power-law extinction at shorter wavelengths, in accordance with recent studies. The extinction law in the 2MASS JHKs bands has also been calculated, and a good agreement with that in the MKO system is found. In nearby molecular clouds and diffuse interstellar medium, the lack of reliable measurements of the total to selective extinction ratios hampers unambiguous determination of the extinction law; however, observational results toward these lines of sight cannot be reconciled with a single extinction law.Comment: 27 pages, 10 figures, Accepted for publication in Ap

Interstellar Extinction Law in the J, H, and Ks Bands toward the Galactic Center

We have determined the ratios of total to selective extinction in the near-infrared bands (J, H, Ks) toward the Galactic center from the observations of the region |l| < 2.0deg and 0.5deg < |b| < 1.0deg with the IRSF telescope and the SIRIUS camera. Using the positions of red clump stars in color-magnitude diagrams as a tracer of the extinction and reddening, we determine the average of the ratios of total to selective extinction to be A(Ks)/E(H-Ks) = 1.44+-0.01, A(Ks)/E(J-Ks) = 0.494+-0.006, and A(H)/E(J-H) = 1.42+-0.02, which are significantly smaller than those obtained in previous studies. From these ratios, we estimate that A(J) : A(H) : A(Ks) = 1 : 0.573+-0.009 : 0.331+-0.004 and E(J-H)/E(H-Ks) = 1.72+-0.04, and we find that the power law A(lambda) \propto lambda^{-1.99+-0.02} is a good approximation over these wavelengths. Moreover, we find a small variation in A(Ks)/E(H-Ks) across our survey. This suggests that the infrared extinction law changes from one line of sight to another, and the so-called ``universality'' does not necessarily hold in the infrared wavelengths.Comment: 18 pages, 9 figures, Accepted for publication in the Ap

Osteolytic bone lymphoma

Primary non-Hodgkin bone lymphoma (PBL) can involve solitary or multiple destructive bone lesions such as those of the femur or pelvis humerus, and some cases have osteolytic lesions. PBL is a rare disease in adults. Thus, PBL is rarely considered a differential diagnosis of the osteolytic tumor. In addition, PBL can be underdiagnosed because patients do not experience symptoms or show objective abnormalities in the early stage. Here, we reported an elderly patient with PBL in multiple bones, including the cranial and femoral bones that were fractured due to falling

A Distinct Structure Inside the Galactic Bar

We present the result of a near-infrared (J H Ks) survey along the Galactic plane, -10.5deg < l < +10.5deg and b=+1.0deg, with the IRSF 1.4m telescope and the SIRIUS camera. Ks vs. H-Ks color-magnitude diagrams reveal a well-defined population of red clump (RC) stars whose apparent magnitude peak changes continuously along the Galactic plane, from Ks=13.4 at l=-10deg to Ks=12.2 at l=+10deg after dereddening. This variation can be explained by the bar-like structure found in previous studies, but we find an additional inner structure at |l| < 4deg, where the longitude - apparent magnitude relation is distinct from the outer bar, and the apparent magnitude peak changes by only 0.1 mag over the central 8deg. The exact nature of this inner structure is as yet uncertain.Comment: 8 pages, 4 figures. accepted by ApJ

Safety and effectiveness of pembrolizumab monotherapy in Japanese patients with unresectable urothelial carcinoma: a nation-wide post-marketing surveillance

Abstract Background This study was conducted to identify factors associated with the safety and effectiveness of pembrolizumab in Japanese patients with unresectable urothelial carcinoma and to confirm the real-world safety and effectiveness of pembrolizumab in Japanese patients. Methods This multicenter, observational, post-marketing surveillance was conducted over a 1-year observation period starting at pembrolizumab initiation (200-mg pembrolizumab every 3 weeks); data were collected from case report forms (3 months and 1 year). Safety measures included treatment-related adverse events and adverse events of special interest (AEOSI). Effectiveness assessments included tumor response, objective response rate (ORR), and disease control rate (DCR). Results Overall, 1293 patients were evaluated for safety and 1136 for effectiveness. At 12 months, the treatment-related adverse event incidence was 53.8% (n = 696) and that of AEOSI was 25.0% (n = 323). The most frequent AEOSI of any grade were endocrinological disorder (10.4%, n = 134), interstitial lung disease (ILD) (7.2%, n = 93), and hepatic function disorder (4.9%, n = 64). Multivariate analysis demonstrated that the risk of developing ILD was almost seven times greater (odds ratio 6.60) in patients with a comorbidity of ILD, and approximately twice as high in patients aged ≥ 65 years (odds ratio 2.24) and with smoking history (odds ratio 1.79). The ORR was 26.1% and the DCR was 50.7%. The ORR was 46.4% in patients with a Bellmunt risk score of 0 and decreased as the Bellmunt risk score increased. Conclusions This post-marketing surveillance confirmed the safety and effectiveness of pembrolizumab in Japanese patients with unresectable urothelial carcinoma in the real-world setting