A Time-Varying Gerber Statistic: Application of a Novel Correlation Metric to Commodity Price Co-Movements

This study investigates the daily co-movements in commodity prices over the period 2006–2020 using a novel approach based on a time-varying Gerber correlation. The statistic is computed considering a set of probabilities estimated via non-traditional models that give a time-varying structure to the measure. The results indicate that there are several co-movements across commodities, that these co-movements change over time, and that they are tendentially positive. Conditional auto-regressive multithreshold logit models show higher forecasting accuracy for agricultural returns, while dynamic conditional correlation models are more accurate for energy products and metals. The proposed models are shown to be superior in terms of forecasting power to the benchmark method which is based on estimating the Gerber correlation moving a rolling window

Experimental flight testing of night vision imaging systems in military fighter aircraft

This paper describes the research and experimental flight test activities conducted by the Italian Air Force Official Test Centre (RSV), in collaboration with Alenia Aermacchi and Cranfield University, in order to confer night vision imaging systems (NVIS) capability to the Italian TORNADO Interdiction and Strike and Electronic Combat and Reconnaissance aircraft. The activities included design, development, test, and evaluation activities, including night vision goggle (NVG) integration, cockpit instruments, and external lighting modifications, as well as various ground test sessions and a total of 18 flight test sorties. RSV and Litton Precision Products were responsible for coordinating and conducting the installation of the internal and external lights. Particularly, an iterative process was established allowing in-site rapid correction of the major deficiencies encountered during the ground and flight test sessions. Both single-ship (day/night) and formation (night) flights were performed, with testing activities shared among the test crews involved, allowing for a redundant examination of the various test items by all participants. An innovative test matrix was developed and implemented by RSV for assessing the operational suitability and effectiveness of the various modifications implemented. Also important was the definition of test criteria for Pilot and Weapon Systems Officer workload assessment during the accomplishment of various operational tasks during NVG missions. Furthermore, the specific technical and operational elements required for evaluating the modified helmets were identified, allowing an exhaustive comparative evaluation of the two proposed solutions (i.e., HGU-55P and HGU-55G modified helmets). The initial compatibility problems encountered were progressively mitigated by incorporating modifications in both front and rear cockpits at various stages of the test campaign. This process allowed considerable enhancement of the TORNADO NVIS configuration, giving good medium- to high-level NVG operational capability to the aircraft. Further developments also include the internal/external lighting for the Italian TORNADO “Mid-Life Update” and other programs such as AMX aircraft internal/external light modification/testing and the activities addressing low-altitude NVG operations with fast jets (e.g., TORNADO, AMX, MB-339CD), with a major issue being the safe ejection of aircrew with NVG and NVG modified helmets. Two options have been identified for solving this problem, namely, the modification of the current Gentex HGU-55 helmets and the design of a new helmet incorporating a reliable NVG connection/disconnection device (i.e., a mechanical system fully integrated in the helmet frame) with embedded automatic disconnection capability in case of ejection. Other relevant issues to be accounted for in these new developments are the helmet dimensions and weight, the NVG usable field of view as a function of eye-relief distance, and the helmet's center of gravity (moment arms) with and without NVG (effect on aircrew fatigue during training and real operational missions

Religious freedom before, during and after Covid-19 between Europe and the Member States

Interventi tenuti il 26 novembre 2021 in occasione del Seminario di studio sul tema “Religious freedom before, during and after covid-19 between Europe and the Member States” organizzato dall’Eulerit Academic Forum dell’Università degli Studi di Trieste col supporto del Modulo Jean Monnet su “The European impact on the regulation Law&Religion in Italy and Beyond

Immunomediated and ischemia-independent inflammation of coronary microvessels in unstable angina.

This study investigated whether the myocardium is involved in the acute inflammatory reaction associated with bursts of unstable angina (UA). We looked for the presence of activated DR+ inflammatory cells and the expression patterns, localization, and immunostaining identification of genes for cytokines (IL-1beta, TNF-alpha, IL-6, and IFN-gamma), MCP-1, and iNOS in the left ventricle biopsies from 2-vessel disease anginal patients, 24 with UA and 12 with stable angina (SA), who underwent coronary bypass surgery. Biopsy specimens from 6 patients with mitral stenosis who underwent valve replacement were examined as control hearts (CHs). Plasma levels of IL-2 soluble receptor (sIL-2R) were measured as a marker of systemic immune reaction. In CHs, DR+ cells were undetectable, and cytokine and iNOS mRNA expression were negligible. UA patients had higher sIL-2R levels than SA patients (P<0.01), and their biopsy specimens showed both numerous DR+ cells identified as lymphocytes, macrophages, endothelial cells, and elevated expression levels of cytokine and iNOS genes (from 2.4- to 6.1-fold vs SA; P<0.01). Cytokine and iNOS genes and proteins were localized in endothelial cells without involvement of myocytes. IL-1beta and MCP-1 mRNAs were nearly undetectable. No significant differences were found in the number of DR+ cells, levels of cytokine, and iNOS genes between potentially ischemic and nonischemic left ventricle areas. In SA specimens, DR+ cells were very rare and only mRNAs for TNF-alpha and iNOS genes were overexpressed versus CHs. These results indicated that an acute immunomediated inflammatory reaction, essentially involving coronary microvessels, is demonstrable in UA patients

The role of rehabilitation in the management of late-onset Pompe disease: a narrative review of the level of evidence

Late-onset Pompe disease (LOPD) is characterized by progressive muscle weakness, respiratory muscle dysfunction, and minor cardiac involvement. Although in LOPD, as in other neuromuscular diseases, controlled low impact sub-maximal aerobic exercise and functional ability exercise can improve general functioning and quality of life, as well as respiratory rehabilitation, the bulk of evidence on that is weak and guidelines are lacking. To date, there is no specific focus on rehabilitation issues in clinical recommendations for the care of patients with Pompe disease, and standard practice predominantly follows general recommendation guidelines for neuromuscular diseases. The Italian Association of Myology, the Italian Association of Pulmonologists, the Italian Society of Neurorehabilitation, and the Italian Society of Physical Medicine and Rehabilitation, have endorsed a project to formulate recommendations on practical, technical, and, whenever possible, disease-specific guidance on rehabilitation procedures in LOPD, with specific reference to the Italian scenario. In this first paper, we review available evidence on the role of rehabilitation in LOPD patients, particularly addressing the unmet needs in the management of motor and respiratory function for these patients

Case Report: Rare Homozygous RNASEH1 Mutations Associated With Adult-Onset Mitochondrial Encephalomyopathy and Multiple Mitochondrial DNA Deletions

Mitochondrial DNA (mtDNA) maintenance disorders embrace a broad range of clinical syndromes distinguished by the evidence of mtDNA depletion and/or deletions in affected tissues. Among the nuclear genes associated with mtDNA maintenance disorders, RNASEH1 mutations produce a homogeneous phenotype, with progressive external ophthalmoplegia (PEO), ptosis, limb weakness, cerebellar ataxia, and dysphagia. The encoded enzyme, ribonuclease H1, is involved in mtDNA replication, whose impairment leads to an increase in replication intermediates resulting from mtDNA replication slowdown. Here, we describe two unrelated Italian probands (Patient 1 and Patient 2) affected by chronic PEO, ptosis, and muscle weakness. Cerebellar features and severe dysphagia requiring enteral feeding were observed in one patient. In both cases, muscle biopsy revealed diffuse mitochondrial abnormalities and multiple mtDNA deletions. A targeted next-generation sequencing analysis revealed the homozygous RNASEH1 mutations c.129-3C&gt;G and c.424G&gt;A in patients 1 and 2, respectively. The c.129-3C&gt;G substitution has never been described as disease-related and resulted in the loss of exon 2 in Patient 1 muscle RNASEH1 transcript. Overall, we recommend implementing the use of high-throughput sequencing approaches in the clinical setting to reach genetic diagnosis in case of suspected presentations with impaired mtDNA homeostasis