Lepton electric dipole moments in supersymmetric type II seesaw model

AbstractWe study the lepton electric dipole moments in the framework of the supersymmetric type II seesaw model where the exchange of heavy SU(2)W triplets generates small neutrino masses. We show that the CP violating phase of the bilinear soft supersymmetry breaking term associated with the SU(2)W triplets contributes to lepton electric dipole moments mainly through threshold corrections to the gaugino masses at the seesaw scale. As a consequence, the ratio of the electric dipole moments of the muon and the electron is the same as the ratio of their masses in a wide region of parameter space

Molecular dynamics simulation of proton-transfer coupled rotations in ATP synthase FO motor

The FO motor in FOF1 ATP synthase rotates its rotor driven by the proton motive force. While earlier studies elucidated basic mechanisms therein, recent advances in high-resolution cryo-electron microscopy enabled to investigate proton-transfer coupled FO rotary dynamics at structural details. Here, taking a hybrid Monte Carlo/molecular dynamics simulation method, we studied reversible dynamics of a yeast mitochondrial FO. We obtained the 36°-stepwise rotations of FO per one proton transfer in the ATP synthesis mode and the proton pumping in the ATP hydrolysis mode. In both modes, the most prominent path alternatively sampled states with two and three deprotonated glutamates in c-ring, by which the c-ring rotates one step. The free energy transduction efficiency in the model FO motor reached ~ 90% in optimal conditions. Moreover, mutations in key glutamate and a highly conserved arginine increased proton leakage and markedly decreased the coupling, in harmony with previous experiments. This study provides a simple framework of simulations for chemical-reaction coupled molecular dynamics calling for further studies in ATP synthase and others

Performance of the TPC with Micro Pixel Chamber Readout: micro-TPC

Micro-TPC, a time projection chamber(TPC) with micro pixel chamber($\mu$-PIC) readout was developed for the detection of the three-dimensional fine(sub-m illimeter) tracks of charged particles. We developed a two-dimensional position sensitive gaseous detector, or the $\mu$-PIC, with the detection area of 10$\times$10 cm${}^{2}$ and 65536 anode electrodes of 400 $\mu$m pitch. We achieved the gas gain of over 10000 without any other multipliers. With the pipe-line readout system specially developed for the $\mu$-PIC, we detected X-rays at the rate as high as 7.7 Mcps. We attached a drift cage with an 8 cm drift length to the $\mu$-PIC and developed a micro-TPC. We measured the basic performances of the micro-TPC and took three-dimensional tracks of electrons. We also developed a prototype of the MeV gamma-ray imaging detector which is a hybrid of the micro-TPC and NaI(Tl) scintillators and confirmed its concept by reconstructing the obtained data.Comment: 6 pages 16 figures, submitted for IEEE/TNS 200

Performance of a micro-TPC for a time-resolved neutron PSD

We report on the performance of a micro-TPC with a micro pixel chamber($\mu$-PIC) readout for a time-resolved neutron position-sensitive detector(PSD). Three-dimensional tracks and the Bragg curves of protons with energies of around 1 MeV were clearly detected by the micro-TPC. More than 95% of gamma-rays of 511 keV were found to be discriminated by simple analysis. Simulation studies showed that the total track length of proton and triton emitted from the $\rm {}^{3}He$(n,p(573 keV))$\rm {}^{3}H(191 keV)$ reaction is about 1.2 cm, and that both particles have large energy losses ($\rm > 200 keV/cm$) in 1 atm Ar+$\rm C_{2}H_{6}(10$+${}^{3}$He($< 1$). These values suit the current performance of the micro-TPC, and we conclude that a time-resolved neutron PSD with spatial resolution of sub-millimeters shall be developed as an application of the micro-TPC.Comment: 13 pages, 10 figures, to appear in NIM

751-6 Multiple Repeat Coronary Angioplasty for Final Lesion Patency

To demonstrate that multiple repeat coronary angioplasty can be solely utilized to achieve final lesion patency after restenosis, such a protocol was prospectively applied for restenosis since 1983. Bypass surgery was only considered for 1) new left main trunk lesions, 2) symptomatic restenosis where angioplasty was either unsuccessful or unsuitable, and 3) patient preference. Between 1983 and 1992, 1455 lesions (acute myocardial infarction or total occlusion excluded) were successfully dilated for the first time. Although only 941 (68%) of the 1385 lesions studied showed satisfactory patency (≤ 70% stenosis) after the first procedure, 93% (1248/1345 studied) showed satisfactory patency after repeating angioplasty up to 3 times and 94% (1268/1354 studied) after repetition up to 6 times. Only 23 lesions 11.6%) required 4 or more procedures and 20 of them showed final patency. Disease aggravation (either impossible or failed repeat angioplasty, acute infarction, or sudden death) occurred in 43 lesions (3.2%). Bypass grafts were done for 11 lesions of 7 patients, mostly due to disease progression at the left main trunk.Dilatation (stenosis)Patent (0–50%)Mild (55-70%)Re-do(75%-)Grafts(75%-)Medical(75%-)Aggravated#WithdrawalCumulative0–70%No*1st87467384916327394113822nd221229706731118413513rd5311230136124813454th11181010126113455th3320000126713456th100100012681345*:1763- ∑ Withdrawal#:sudden death. acute infarction or irreversible occlusionConclusionThese findings indicate that 1) repeat angioplasty can be the main treatment strategy for restenosis, 2) multiple repeat angioplasties (up to 6 times) can be effective and rarely aggravate coronary anatomy and 3) disease aggravation must be prevented to improve the final patency rate of repeat ang ioplasty

Effect of Coconut Water Extract on the Growth and Serum Biochemical Values of Rats Fed Fish Oil Diet

ABSTRACT To justify the safety of ethanolic extract of coconut water (CWE), a study with rats was conducted. Wistar rats fedfish oil diet and rats fed the standard diei of AIN93G groupi were orally administrated 0.8 ml CWE/rat twice per day for 14 days. During experimental period, the behavior and growth of rats were monitored. At the end of experiment, the rats were anaesthetized and the internal organs were taken and measuredfor each weight. Blood was taken from the hearth and then analyzed for serum biochemical values and TBARS. The results, no adverse effects of CWE administration were observed as evaluated by growth pattern, food intake and feces appearance. Serum biochemical values and weight of internal organs of CWE receiving rats were comparable to those of untreated control. SeruniTBARS value of rats fedfish oil was significantly higher than that of those ed standard diet, however, oral administratibn of CWE did not significantly decreaie serum TBAR

Studies on the mechanism of phagocytosis. I. Effect of metabolic inhibitors on the phagocytosis of iron colloid particles by ascites macrophages

For the purpose to clarify the mechanism of phagocytosis or pinocytosis, the observations on the tumor ascites, including the macrophages as well as the tumor cells, were carried out by incubating with the iron colloid with or without pretreatment by several inhibibitors of glycolysis, oxidative phosphorylation and respiration, or under hypotonic or cold environments. The results have demonstrated that there are three steps in the phagocytosis. The first step is the adhesion of the substance to the cell surface, which is not an energy-requiring process. The second step is the engulfing which proceeds by using the energy supplied by glycolysis. The third is the accumulation of the substance into the vesicles through the canaliculi connecting the cell surface with the vesicles. The discussion was made on the existence of the active site on the cell surface to which the substance can be adhered, and the accumulation mechanism of the material into the phagocytic vesicles by the membrane flow, the flowing movement of the outer lipid layer of a unit membrane through the canaliculi which connect the cell surface to the phagocytic vesicles.</p