Knee kinematics and kinetics in former soccer players with a 16-year-old ACL injury – the effects of twelve weeks of knee-specific training

BACKGROUND: Training of neuromuscular control has become increasingly important and plays a major role in rehabilitation of subjects with an injury to the anterior cruciate ligament (ACL). Little is known, however, of the influence of this training on knee stiffness during loading. Increased knee stiffness occurs as a loading strategy of ACL-injured subjects and is associated with increased joint contact forces. Increased or altered joint loads contribute to the development of osteoarthritis. The aim of the study was to determine if knee stiffness, defined by changes in knee kinetics and kinematics of gait, step activity and cross-over hop could be reduced through a knee-specific 12-week training programme. METHODS: A 3-dimensional motion analysis system (VICON) and a force plate (AMTI) were used to calculate knee kinetics and kinematics before and after 12 weeks of knee-specific training in 12 males recruited from a cohort with ACL injury 16 years earlier. Twelve uninjured males matched for age, sex, BMI and activity level served as a reference group. Self-reported patient-relevant data were obtained by the KOOS questionnaire. RESULTS: There were no significant changes in knee stiffness during gait and step activity after training. For the cross-over hop, increased peak knee flexion during landing (from 44 to 48 degrees, p = 0.031) and increased internal knee extensor moment (1.28 to 1.55 Nm/kg, p = 0.017) were seen after training, indicating reduced knee stiffness. The KOOS sport and recreation score improved from 70 to 77 (p = 0.005) and was significantly correlated with the changes in knee flexion during landing for the cross-over hop (r = 0.6, p = 0.039). CONCLUSION: Knee-specific training improved lower extremity kinetics and kinematics, indicating reduced knee stiffness during demanding hop activity. Self-reported sport and recreational function correlated positively with the biomechanical changes supporting a clinical importance of the findings. Further studies are needed to confirm these results in women and in other ACL injured populations

Expression of VEGF receptors VEFGR-1 and VEGFR-2, angiopoietin receptors Tie-1 and Tie-2 in chorionic villi tree during early pregnancy.

The aim of this study was to determine the expression of VEGF and its receptors in placentas from normal pregnancies between 22 days p.c. and 48 days p.c. of very early pregnancy. Placental tissues carried out from 19 pregnant women were examined. Immunohistochemical technique, electron microscopy were employed to evaluate the factors expression. In the new developing mesenchymal villi and immature intermediate villi VEGF and its receptors VEGFR-1 and VEGFR-2 immunoreactivity was detected in all the placental components, while in the stem villi and in the chorionic plate with large vessels only in some components. In the mesenchymal villi and immature intermediate villi VEGFR-1 and -2, and angiopoietin receptors Tie-1 and -2 immunoreactivity was dominantly observed in the heamangiogenic cells and cells cords, whereas the matured villi showed immunoreactivity only in other components. The ultrastructural findings were higher in respect to the all of the early pregnancy days. The placental samples from all of pregnancies, showed the VEGF and its receptors in optimal expression levels, whereas the angiopoietin receptors Tie-1 and -2 showed a higher expression levels in respect to other study factors. The receptors protein levels increased from the early days to the advanced days of gestation, but this alteration was not significant. The intensity of the immunolabeling for these proteins were not significant compared to to each other of gestatin days were examined. These findings demonstrated that a dysregulation of the placental expression of the VEGF and its receptors related to the different degrees of the gestational periods. Probably, this event may be related to complete vasculugenesis and angiogenesis in placental villi

Unconditional Basic Income and Welfare State Reform in Representative Democracies

Item does not contain fulltextAn increase in income and wealth inequality does not only have negative social and economic consequences, it is also a threat to the functioning of our democracies. The debate on the introduction of an Unconditional Basic Income (UBI) is beset with unanswered questions, with conjectures and unproven beliefs that call for additional research by economists and a uniform definition. The current distribution-and-income-based national welfare state could be transformed into a ‘prosperity state’, in which the economy is designed around delivering the capabilities for human flourishing. The introduction of a UBI, funded by progressive consumption and wealth taxes, should be on the research agenda of economics, and on the policy agenda in representative democracies. It has the potential to enlarge the economic pie, and to improve the distribution of income, for it reflects the contribution to society. Empirics on UBI are limited. Moreover, research is mainly focussed on short-term labour market effects, poverty and income inequality reduction, and there is some attention for health and well-being. However, the long-term effect on the environment are fully disregarded. The aim of this book is to scrutinise and comment on some of the main issues of the basic income, to contribute to the knowledge basis on the basic income, and to support better informed—evidence-based—policy making, and to bring a better world about

A relação entre o social e o natural nas abordagens de hazards e de desastres The relation between the social and the natural in the approach of hazards and disasters

O artigo aborda as teorias dos Hazards e dos Desastres. Nos últimos anos estas duas tradições teóricas têm recebido novos impulsos pela renovação de seus marcos de referência conceitual. Construídas em torno de uma longa tradição de pesquisa empírica, estas teorias explicam os impactos provocados por fenômenos como enchentes, terremotos, tornados e epidemias mediante a integração analítica das dimensões natural e social. Neste sentido, seu estudo pode fornecer subsídios para a interpretação destes problemas no Brasil.<br>The article deals with the theory of hazards and disasters. Over the past years, these two theoretical traditions have received new impulse through the renovation of their conceptual foundations. Constructed around a long tradition of empirical research, these theories explain the impacts brought by phenomena like floods, earthquakes, tornadoes and epidemics through the analytical integration of social and natural dimensions. In this regard, its study may provide grants in order to interpret these problems in Brazil