El ejercicio como modulador en el tratamiento de la hipertension arterial en los habitantes de la comunidad de Santa Cruz Atizapan del Estado de México

La hipertensión arterial (HTA) constituye uno de los problemas médicos sanitarios más importantes de la medicina contemporánea, es un problema de salud de la relevancia mundial, no sólo por los perjuicios que ocasiona en la salud de las personas, sino también por el número apreciable de muertes e incapacidades que produce de manera por su condición de factor de riesgo de otras patologías

Study of X52 steel in seawater with biocides under turbulent flow conditions

This work presents the corrosion study of the API X52 pipeline steel immersed in seawater without biocide and with 0,25, 0,5 and 0,75 ppm of biocide, under static and dynamic (turbulent flow) conditions at room temperature and atmospheric pressure. The total exposure time of the steel sample in test solution was 24h. In order to control the hydrodynamic conditions, a rotating cylinder electrode(RCE) was used. The rotation speed was 1000 RPM. The steel samples were immersed in the test solution, then, an electrochemical corrosion study using linear polarization resistance (LPR), electrochemical impedance spectroscopy (EIS) and polarization curves (PC) was made. In the superficial analysis of the steel samples, a scanning electronic microscopy was used. The results of the electrochemical study shown that the corrosion rate is higher under turbulent flow conditions than static conditions, and as the biocide concentration increased in the test solution, the corrosion rate decreased. A localized corrosion type was found in all the samples tested

First record of the Sparkling-tailed Hummingbird (Tilmatura dupontii, Trochilidae) for Sierra de Huautla Biosphere Reserve, Morelos, Mexico

In August, 2005 we observed and photographed one male of Sparkling-Tailed hummingbird (Tilmatura dupontii) foraging on Firerbush shrub flowers (Hamelia patens, Rubiaceae). The present observation is the first record of this species for the Sierra de Huautla Biosphere Reserve, in the south of Morelos, Mexico, ca. 50 km southeast of previous reported observations of the species in Morelo

Cell death and biomass reduction in biofilms of multidrug resistant extended spectrum β-lactamase-producing uropathogenic Escherichia coli isolates by 1,8-cineole

Escherichia coli is the most frequent agent of urinary tract infections in humans. The emergence of uropathogenic multidrug-resistant (MDR) E. coli strains that produce extended spectrum β-lactamases (ESBL) has created additional problems in providing adequate treatment of urinary tract infections. We have previously reported the antimicrobial activity of 1,8-cineole, one of the main components of Rosmarinus officinalis volatile oil, against Gram negative bacteria during planktonic growth. Here, we evaluated the antibiofilm activity of 1,8-cineole against pre-formed mature biofilms of MDR ESBL-producing uropathogenic E. coli clinical strains by carrying out different technical approaches such as counting of viable cells, determination of biofilm biomass by crystal violet staining, and live/dead stain for confocal microscopy and flow cytometric analyses. The plant compound showed a concentration- and time-dependent antibiofilm activity over pre-formed biofilms. After a 1 h treatment with 1% (v/v) 1,8-cineole, a significant decrease in viable biofilm cell numbers (3-log reduction) was observed. Biofilms of antibiotic-sensitive and MDR ESBL-producing E. coli isolates were sensitive to 1,8-cineole exposure. The phytochemical treatment diminished the biofilm biomass by 48-65% for all four E. coli strain tested. Noteworthy, a significant cell death in the remaining biofilm was confirmed by confocal laser scanning microscopy after live/dead staining. In addition, the majority of the biofilm-detached cells after 1,8-cineole treatment were dead, as shown by flow cytometric assessment of live/dead-stained bacteria. Moreover, phytochemical-treated biofilms did not fully recover growth after 24 h in fresh medium. Altogether, our results support the efficacy of 1,8-cineole as a potential antimicrobial agent for the treatment of E. coli biofilm-associated infections.Fil: Vázquez, Nicolás Martín. Universidad Maimónides. Área de Investigaciones Biomédicas y Biotecnológicas. Centro de Estudios Biomédicos, Biotecnológicos, Ambientales y de Diagnóstico; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Mariani, Florencia. Universidad Maimónides. Área de Investigaciones Biomédicas y Biotecnológicas. Centro de Estudios Biomédicos, Biotecnológicos, Ambientales y de Diagnóstico; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Torres, Pablo Sebastian. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Ciencia y Tecnología "Dr. César Milstein". Fundación Pablo Cassará. Instituto de Ciencia y Tecnología "Dr. César Milstein"; ArgentinaFil: Moreno, Silvia. Universidad Maimónides. Área de Investigaciones Biomédicas y Biotecnológicas. Centro de Estudios Biomédicos, Biotecnológicos, Ambientales y de Diagnóstico; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Galvan, Estela Maria. Universidad Maimónides. Área de Investigaciones Biomédicas y Biotecnológicas. Centro de Estudios Biomédicos, Biotecnológicos, Ambientales y de Diagnóstico; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentin

Lagrangian Model‐Based Fault Diagnosis in a PVTOL

A Lagrangian formalism is used to model a PVTOL in order to obtain an aircraft model. The Euler‐Lagrange model of the PVTOL is used to develop an algorithm for fault diagnosis. Diagnosis implies the detection, isolation and identification of a fault. The considered approach is based on the knowledge of a system model as well as the model of the possible faults. The idea is to use non‐linear decoupling approach to derivate a set of subsystems, each related to a specific fault or a set of faults. An observer‐based residual generation is designed for each subsystem, this structure allows the fault detection and isolation stage, for fault identification a kind of approximated inversion algorithm to meet the different diagnostic levels. The results are obtained taking advantage of the structure given by the Euler‐Lagrange modelling of the PVTOL as well as from recent results related to observer design and fault identification

A study of differential microRNA expression profile in migraine: the microMIG exploratory study

Epigenetics; Migraine; MicroRNAEpigenética; Migraña; MicroARNEpigenètica; Migranya; MicroARNBackground Several studies have described potential microRNA (miRNA) biomarkers associated with migraine, but studies are scarcely reproducible primarily due to the heterogeneous variability of participants. Increasing evidence shows that disease-related intrinsic factors together with lifestyle (environmental factors), influence epigenetic mechanisms and in turn, diseases. Hence, the main objective of this exploratory study was to find differentially expressed miRNAs (DE miRNA) in peripheral blood mononuclear cells (PBMC) of patients with migraine compared to healthy controls in a well-controlled homogeneous cohort of non-menopausal women. Methods Patients diagnosed with migraine according to the International Classification of Headache Disorders (ICHD-3) and healthy controls without familial history of headache disorders were recruited. All participants completed a very thorough questionnaire and structured-interview in order to control for environmental factors. RNA was extracted from PBMC and a microarray system (GeneChip miRNA 4.1 Array chip, Affymetrix) was used to determine the miRNA profiles between study groups. Principal components analysis and hierarchical clustering analysis were performed to study samples distribution and random forest (RF) algorithms were computed for the classification task. To evaluate the stability of the results and the prediction error rate, a bootstrap (.632 + rule) was run through all the procedure. Finally, a functional enrichment analysis of selected targets was computed through protein–protein interaction networks. Results After RF classification, three DE miRNA distinguished study groups in a very homogeneous female cohort, controlled by factors such as demographics (age and BMI), life-habits (physical activity, caffeine and alcohol consumptions), comorbidities and clinical features associated to the disease: miR-342-3p, miR-532-3p and miR-758-5p. Sixty-eight target genes were predicted which were linked mainly to enriched ion channels and signaling pathways, neurotransmitter and hormone homeostasis, infectious diseases and circadian entrainment. Conclusions A 3-miRNA (miR-342-3p, miR-532-3p and miR-758-5p) novel signature has been found differentially expressed between controls and patients with migraine. Enrichment analysis showed that these pathways are closely associated with known migraine pathophysiology, which could lead to the first reliable epigenetic biomarker set. Further studies should be performed to validate these findings in a larger and more heterogeneous sample.This study was solely funded by the Migraine Research Foundation

Diet and trophic level of scalloped hammerhead shark (Sphyrna lewini) from the Gulf of California and Gulf of Tehuantepec, Mexico

We examined the diet and trophic level of Sphyrna lewini in the Gulf of California (GC) during 2001 and in the Gulf of Tehuantepec (GT) during 2005 using data from stomach content and stable isotope analysis of δ15N and δ13C. S. lewini diet was represented by pelagic and benthic prey species where the most important in weight was Scomber japonicus (27.70±4.54%) in GC, while in GT it was Auxis spp. (26.19±4.14%). There were differences for δ15N and δ13C between group sizes, showing a difference in the use of area and resources, while the differences for δ15N and δ13C between areas were related to changes in the isotopic signal from the base of the food web in each region. Based on δ13C and δ15N variability, diversity values (GC=3.69; GT=3.17) and diet breadth (GC=0.006; GT=0.002), we propose that S. lewini is an opportunistic predator. The trophic level of S. lewini was above four in all categories, which indicates that S. lewini is a tertiary consumer. We may conclude that S. lewini plays an important functional role as top predator within areas of Mexico

Molecular and biochemical characterization of extracellular tannin acyl hydrolase activity from a Mexican isolate of Aspergillus niger

"Microbial tannase, a hydrolysable tannin-degrading enzyme, is extensively used in manufacture of instant tea, beer, wine, and gallic acid. Aspergillus niger strain, obtained from a Mexican tannery wastewaters rich in gallic acid [Quebracho Phenolics-rich Tannery Wastewaters, (QPTW)], displayed a good growth and tannase activity in a minimal medium added with 1% (w/v) QPTW (Kr= 0.451 mm.h-1). Using PCR and RACE 3´ and 5´methodologies, a complete cDNA of a tannase was cloned from this isolate.Nucleotide sequence of complete cDNA was of 4690 bp with a complete ORF of 1833 bp encoding 611 amino acids. Transcriptionalinduction was observed in mineral medium added with carbon sources as tannic acid alone (1 and 10 g/l), as well as mix of glucose(1 and 10 g/l) and tannic acid (1 g/l) in the media. However, neither glucose (1 and 10 g/l) and sucrose (1 and 10 g/l) nor (+)-catechin(1 and 10 g/l) as sole carbon sources displayed gene induction in in vitro assays. A. niger-GTO is a new strain with interesting characteristics for industrial tannase production purposes.

Assessment of the length of sick leave in patients with ischemic heart disease

Acute coronary syndrome; Coronary heart disease; Sick leaveSíndrome Coronario Agudo; Enfermedad Coronaria; Ausencia por enfermedadSíndrome coronari agut; Malaltia coronària; Absència per malaltiaBACKGROUND The prevalence of ischemic heart disease is high. Few recent studies have investigated the periods of sick leave of these patients. Our aim is to determine the length of sick leave after an acute coronary syndrome, its costs, associated factors and to assess the use of antidepressants and/or anxiolytics. METHODS An observational study of a retrospective cohort of patients on sick leave due to ischemic heart disease in a health region between 2008-2011, with follow-up until the first return to work, death, or end of the study (31/12/2012). MEASUREMENTS length of sick leave, sociodemographic variables and medical prescriptions. RESULTS Four hundred and ninety-seven patients (mean age 53 years, 90.7% male), diagnosed with acute myocardial infarction (60%), angina pectoris (20.7%) or chronic form of ischemic heart disease (19.1%). Thirty-seven per cent of patients took anxiolytics the year after diagnosis and 15% took antidepressants. The average duration of sick leave was 177 days (95% CI: 163-191 days). Patients diagnosed with acute myocardial infarction returned to work after a mean of 192 days, compared to 128 days in cases with angina pectoris. Patients who took antidepressants during the year after diagnosis returned to work after a mean of 240 days. The mean work productivity loss was estimated to be 9,673 euros/person. CONCLUSIONS The mean duration of sick leave due to ischemic heart disease was almost six months. Consumption of psychotropic medication doubled after the event. Older age, suffering an acute myocardial infarction and taking antidepressants were associated with a longer sick leave period