Pilot Study of Skin Cancer Risk Reduction Behaviors, Cancer Communication, and Skin Cancer Beliefs in Hispanics

Purpose: Given rising rates of deadly melanoma skin cancer in Hispanics, the study objective was to examine skin cancer-related risk reduction behaviors and beliefs to dictate content for culturally targeted skin cancer prevention strategies for Hispanics. Methods/Data Source: An anonymous survey was administered to waiting room volunteers in a primary care facility in Albuquerque, New Mexico to assess skin cancer risk reduction behaviors, screening, cancer information seeking and communication, as well as skin cancer beliefs in Hispanics (n=48) and Non-Hispanic Whites (n=36). Results: We found lower levels of sun protection clothing use among Hispanics compared to Non-Hispanic Whites, but comparable use of sunscreen and shade-seeking among these groups. Hispanic ethnicity was the most important predictor of skin cancer misconceptions, with skin cancer information overload and misconceptions reported more often in Hispanics. Conclusions: This study demonstrates the need for culturally relevant information for ethnic minority populations such as Hispanics who have shown an increased risk of presenting with later stage, more aggressive melanoma skin cancer

La investigación científica sobre Cine en España a partir de sus tesis doctorales: Análisis de redes sociales (1978-2007)

El objetivo del presente trabajo es analizar la construcción académica de la investigación en cine en España en el periodo (1976-2007) utilizando datos extraídos de las tesis producidas en el área. Para ello se ha empleado el Análisis de Redes Sociales analizándose la composición reticular de los tribunales. Los datos han sido extraídos de la Base de Datos TESEO. Se han generado redes temporales con el objeto de estudiar los diferentes periodos, los grupos sociales protagonistas y su evolución temporal. Igualmente se han generado redes de selección de tribunales por Universidad y director. Las redes confirman el carácter multidisciplinar y polifacético de la investigación sobre cine, la existencia de diferentes grupos activos en los procesos de producción científica.Las estructuras de las redes se articulan en torno a la universidad Complutense de Madrid, Universidad de Barcelona y Universidad de Valenci

Actuador con mecanismo de rigidez variable y par umbral

Número de publicación: ES2387228 A1 (18.09.2012) También publicado como: ES2387228 B2 (05.02.2013) Número de Solicitud: Consulta de Expedientes OEPM (C.E.O.) P201200712 (29.06.2012)Actuador con mecanismo de rigidez variable y par umbral, del tipo de los utilizados en articulaciones de revolución de brazos robóticos y que pueden modificar su rigidez. El actuador incorpora un motor (1) que se encarga de controlar la posición de equilibrio del eslabón de salida (13). El mecanismo contiene un resorte (18) y una palanca (12). La rigidez del mecanismo puede ser modificada variando la posición de esta palanca (12) mediante un motor (14). Dicha rigidez determina el valor del giro entre la posición de la polea (2) solidaria al eje de salida del motor (1) y la posición del eslabón (13). Dos tensores (5) y (6) permiten modificar la precarga de dos cables (3) y (4) respectivamente, de forma que el mecanismo no entra en funcionamiento hasta que no se ha sobrepasado un cierto valor de par sobre la articulación.Universidad de Almerí

Caso de estudio HSEQ en Fabrica de Manufacturera de Llantas

Analisis de estudio de un caso real para un sector productivo basado en la Norma ISO 14001:2015 que sintetiza el aprendizaje obtenido durante el desarrollo del diplomado de gerencia HSEQ para lo cual se ha realizado en una empresa de manufactura de llantas.Study analysis of a real case for a productive sector based on the ISO 14001: 2015 Standard, which synthesizes the learning obtained during the development of the HSEQ management diploma, for which it has been carried out in a tire manufacturing company

Adolescentes, sexismo y violencia basada en género en centros rurales de población del departamento Villaguay, Entre Ríos

Este estudio se plantea en un contexto en que un número mayor al 35% de las mujeres en el mundo han sufrido algún tipo de violencia, según informa la Organización de Naciones Unidas (ONU). En Entre Ríos, da a conocer que desde el año 2007 al 2016 se registraron un total de 72 casos en la provincia, de los cuales el 51% de las víctimas tenían entre 16 y 30 años. Según el Registro Judicial de Causas y Antecedentes de Violencia (REJUCAV) de Entre Ríos, en esta provincia se produjeron 25 femicidios entre los años 2018 y 2020. La mayor tasa de mortalidad se observa en el departamento Villaguay, donde se registraron seis casos. Tres sucesos con víctimas menores de 20 años, dos de los cuales ocurrieron en zona rural. Para esto se realizó un estudio con encuadre metodológico mixto, en base a escalas sumativas y entrevistas grupales en una población de adolescentes concurrentes a escuelas de enseñanza media de la zona rural del departamento Villaguay. Los resultados indican una prevalencia de los modelos tradicionalistas en la población rural concentrada, tanto en varones como en mujeres y en la población rural dispersa predomina en las respuestas una alta deseabilidad social. ARK/CAICYT: http://id.caicyt.gov.ar/ark:/s22504559/54o3qtkgq

BRCA2 polymorphic stop codon K3326X and the risk of breast, prostate, and ovarian cancers

Background: The K3326X variant in BRCA2 (BRCA2*c.9976A>T; p.Lys3326*; rs11571833) has been found to be associated with small increased risks of breast cancer. However, it is not clear to what extent linkage disequilibrium with fully pathogenic mutations might account for this association. There is scant information about the effect of K3326X in other hormone-related cancers. Methods: Using weighted logistic regression, we analyzed data from the large iCOGS study including 76 637 cancer case patients and 83 796 control patients to estimate odds ratios (ORw) and 95% confidence intervals (CIs) for K3326X variant carriers in relation to breast, ovarian, and prostate cancer risks, with weights defined as probability of not having a pathogenic BRCA2 variant. Using Cox proportional hazards modeling, we also examined the associations of K3326X with breast and ovarian cancer risks among 7183 BRCA1 variant carriers. All statistical tests were two-sided. Results: The K3326X variant was associated with breast (ORw = 1.28, 95% CI = 1.17 to 1.40, P = 5.9x10- 6) and invasive ovarian cancer (ORw = 1.26, 95% CI = 1.10 to 1.43, P = 3.8x10-3). These associations were stronger for serous ovarian cancer and for estrogen receptor–negative breast cancer (ORw = 1.46, 95% CI = 1.2 to 1.70, P = 3.4x10-5 and ORw = 1.50, 95% CI = 1.28 to 1.76, P = 4.1x10-5, respectively). For BRCA1 mutation carriers, there was a statistically significant inverse association of the K3326X variant with risk of ovarian cancer (HR = 0.43, 95% CI = 0.22 to 0.84, P = .013) but no association with breast cancer. No association with prostate cancer was observed. Conclusions: Our study provides evidence that the K3326X variant is associated with risk of developing breast and ovarian cancers independent of other pathogenic variants in BRCA2. Further studies are needed to determine the biological mechanism of action responsible for these associations

WR1065 mitigates AZT-ddI-induced mutagenesis and inhibits viral replication

The success of nucleoside reverse transcriptase inhibitors (NRTIs) in treating HIV-1 infection and reducing mother-to-child transmission of the virus during pregnancy is accompanied by evidence that NRTIs cause long-term health risks for cancer and mitochondrial disease. Thus, agents that mitigate toxicities of the current combination drug therapies are needed. Previous work had shown that the NRTI-drug pair zidovudine (AZT)–didanosine (ddI) was highly cytotoxic and mutagenic; thus, we conducted preliminary studies to investigate the ability of the active moiety of amifostine, WR1065, to protect against the deleterious effects of this NRTI-drug pair. In TK6 cells exposed to 100 μM AZT-ddI (equimolar) for 3 days with or without 150 μM WR1065, WR1065 enhanced long-term cell survival and significantly reduced AZT-ddI-induced mutations. Follow-up studies were conducted to determine if coexposure to AZT and WR1065 abrogated the antiretroviral efficacy of AZT. In human T-cell blasts infected with HIV-1 in culture, inhibition of p24 protein production was observed in cells treated with 10 μM AZT in the absence or presence of 5–1,000 μM WR1065. Surprisingly, WR1065 alone exhibited dose-related inhibition of HIV-1 p24 protein production. WR1065 also had antiviral efficacy against three species of adenovirus and influenza A and B. Intracellular levels of unbound WR1065 were measured following in vitro/in vivo drug exposure. These pilot study results indicate that WR1065, at low intracellular levels, has cytoprotective and antimutagenic activities against the most mutagenic pair of NRTIs and has broad spectrum anti-viral effects. These findings suggest that the activities have a possible common mode of action that merits further investigation

Operations of and Future Plans for the Pierre Auger Observatory

Technical reports on operations and features of the Pierre Auger Observatory, including ongoing and planned enhancements and the status of the future northern hemisphere portion of the Observatory. Contributions to the 31st International Cosmic Ray Conference, Lodz, Poland, July 2009.Comment: Contributions to the 31st ICRC, Lodz, Poland, July 200