Policy effectiveness and “misalignment” with firms’ strategies: A study of pro-internationalization incentives

Purpose: This paper aims to seek to demonstrate that a non-scientific approach to policy design causes policymakers to persist in the development and use of conventional and inefficient top-down policies. This paper takes the case of the design of official pro-internationalization policy, intended to promote internationalization through outward investment, to reveal inadequacies and inefficiencies in policy design. Through an analysis of the merits of introducing a bottom-up approach, it also aims to show how policy redesign would better yield the desired specific and effective impacts sought by policymakers. Design/methodology/approach: A framework was developed, comprising a set of real policy measures, two indexes to quantify the alignment between government policies and firms’ strategies and a regression model to test the impact of the misalignment on firm performance. This framework uses primary empirical data. Findings: The results are obtained through an item-by-item comparison between use and revealed, or perceived, importance of each type of public support and then, through the indexes, which rank the different types of incentives according to their importance and use. Analysis of these suggests that some measures could be more efficient, and that firms with higher levels of foreign market commitment tend to be more aligned with public policy, and benefit from it most, while those firms with a lower degree of internationalization are the least well served by policy support measures. Originality/value: These results identify systematic weaknesses in policy design and point to the reasons for these weaknesses. The findings suggest that governments tend to craft top-down policy, based on high-level presumptions about the nature of all firms’ strategies towards internationalization and international expansion. We propose that these presumptions result from flawed evaluations of policy effectiveness overly influenced by existing foreign investors, to the detriment of the true and intended strategies of the actual target group of the least internationalized firms. It is concluded that to improve both the efficiency and the effectiveness of policy actions, the traditional top-down intervention paradigm of policy-making should be complemented by policy designed from the bottom-up, making use of reliable information about all firms’ strategies, and taking care to better identify natural target groups of firms according to their existing or potential resources and capabilities

Localized and controlled delivery of nitric oxide to the conventional outflow pathway via enzyme biocatalysis: towards therapy for Glaucoma

Nitric oxide (NO) has been shown to lower intraocular pressure (IOP), however its therapeutic effects on outflow physiology are location- and dose-dependent. Here, a NO delivery platform that directly targets the resistance-generating region of the conventional outflow pathway and locally liberates a controlled dose of NO is reported. An increase in outflow facility (decrease in IOP) is demonstrated in mouse model

Nanoscale Mapping Reveals Functional Differences in Ion Channels Populating the Membrane of Primary Cilia.

BACKGROUND/AIMS: The primary cilium is a nanoscale membrane protrusion believed to act as a mechano-chemical sensor in a range of different cell types. Disruptions in its structure and signalling have been linked to a number of medical conditions, referred to as ciliopathies, but remain poorly understood due to lack of techniques capable of investigating signal transduction in cilia at nanoscale. Here we set out to use latest advances in nanopipette technology to address the question of ion channel distribution along the structure of primary cilium. METHODS: We used glass nanopipettes and Scanning Ion Conductance Microscopy (SICM) to image 3D topography of intact primary cilia in inner medullary collecting duct (IMCD) cells with nanoscale resolution. The high-resolution topographical images were then used to navigate the nanopipette along the structure of each cilium and perform spatially resolved single-channel recordings under precisely controlled mechanical and chemical stimulation. RESULTS: We have successfully obtained first single-channel recordings at specific locations of intact primary cilia. Our experiments revealed significant differences between the populations of channels present at the ciliary base, tip and within extra-ciliary regions in terms of mean conductance and sensitivity to membrane displacement as small as 100 nm. Ion channels at the base of cilium, where mechanical strain is expected to be the highest, appeared particularly sensitive to the mechanical displacement. CONCLUSION: Our results suggest the distribution of ion channels in the membrane of primary cilia is non-homogeneous. The relationship between the location and function of ciliary ion channels could be key to understanding signal transduction in primary cilia

Prevalence and factors associated with polypharmacy in the older people: 2006-2014

To analyse the prevalence, risk factors and evolution over time of polypharmacy and self-medication in the older people in Spain from 2006-2014.info:eu-repo/semantics/publishedVersio

Use of elicitors as an approach for sustainable agriculture

Plant pathogens are responsible for large declines in agricultural production. Their control is carried out mainly by chemical and frequently proposed biological methods to reduce their environmental impact. On the other hand, plant-pathogen or microbe interactions generate multiple signals within plants activating defense mechanism, some of which can also be induced by elicitors (protective molecules). Elicitor-induced plant signaling serves as a guide to a series of intracellular events that end in activation of transduction cascades and hormonal pathways triggering induced resistance (IR) and consequently activation of plant immunity to environmental stresses. So, it is necessary to understand where and how elicitors act in cellular defense mechanism of crops, to improve protection and management for sustainable crop. Therefore this review focused on main topics that guide induced resistance and therefore activation of plant immune response.Keywords: Elicitors, defense mechanism, Immune response, Induced resistance, MAP

Analogies between geminivirus and oncovirus: Cell cycle regulation

Geminiviruses are a large family of plant viruses whose genome is composed of one or two circular and single strand of DNA. They replicate in the cell nucleus being Rep protein, the only viral protein necessary for their replication process. Geminiviruses as same as animal DNA oncoviruses, like SV40, adenovirus and papillomavirus, use the host replication machinery to replicate their DNA. Consequently, they alter host cell cycle regulation to create a suitable environment for their replication. One of the events involved in this alteration would be the inactivation of the retinoblastoma protein (pRb) that negatively regulates the G1/S transition in cells. The discovery of one homologue of the pRb in plants and the finding that Rep protein of some geminiviruses interacts with human retinoblastoma protein, as well as animal virus oncoproteins, is very interesting. This finding laid the groundwork for subsequent detection of analogies between geminiviruses and animal DNA tumor viruses, especially in their interaction with pRb. Moreover, the finding allowed the determination of how this interaction affects the regulation of the cell cycle in plants and animals. Accumulated knowledge generates new interesting questions and possible implications, and so, in this document, we dare to watch in that direction.Key words: Geminivirus, oncovirus, retinoblastoma protein, cell cycle regulation, endoreduplication