ELISA detection of phenazepam, etizolam, pyrazolam, flubromazepam, diclazepam and delorazepam in blood using Immunalysis® benzodiazepine kit

Phenazepam and etizolam were the first uncontrolled benzodiazepines available for sale in the UK. Pyrazolam, flubromazepam and diclazepam are not used medicinally anywhere in the world; they are produced exclusively for the uncontrolled, recreational market. It is important to know whether potentially abused drugs like these can be detected in routine toxicological screening tests. The purpose of this study was to evaluate whether the Immunalysis® Benzodiazepines ELISA kit could detect phenazepam, etizolam, pyrazolam, flubromazepam, diclazepam and its metabolite delorazepam. Their cross-reactivity was assessed by comparing the absorbance of the drug with that of oxazepam, the reference standard. This study found that these uncontrolled benzodiazepines cross-react sufficiently to produce a positive result with the Immunalysis® Benzodiazepine ELISA kit. Cross-reactivity ranged from 79 to 107% for phenazepam, etizolam, pyrazolam, flubromazepam, diclazepam and delorazepam fortified into blood. The results show that it is possible to detect these newer benzodiazepines with traditional forensic toxicology laboratory tools and it is important to include these benzodiazepines in the confirmation tests

AI Lab Faculty

This document is meant to introduce new graduate students in the MIT AI Lab to the faculty members of the laboratory and their research interests. Each entry consists of the faculty member's picture, if available, some information on how to reach them, their responses to a few survey questions, and a few paragraphs excerpted from the AI Lab President's Report, as edited by Patrick Winston.MIT Artificial Intelligence Laborator

No evidence for associations between men's salivary testosterone and responses on the Intrasexual Competitiveness Scale

Objectives: Many previous studies have investigated relationships between men’s competitiveness and testosterone. For example, the extent of changes in men’s testosterone levels following a competitive task predicts the likelihood of them choosing to compete again. Recent work investigating whether individual differences in men’s testosterone levels predict individual differences in their competitiveness have produced mixed results. Methods: In light of the above, we investigated whether men’s (N = 59) scores on the Intrasexual Competitiveness Scale were related to either within-subject changes or between-subject differences in men’s salivary testosterone levels. Results: Men’s responses on the Intrasexual Competitiveness Scale did not appear to track within-subject changes in testosterone. By contrast with one recent study, men’s Intrasexual Competitiveness Scale also did not appear to be related to individual differences in testosterone. Conclusions: Our results present no evidence for associations between men’s testosterone and their responses on the Intrasexual Competitiveness Scale

The relative contributions of facial shape and surface information to perceptions of attractiveness and dominance

Although many studies have investigated the facial characteristics that influence perceptions of others’ attractiveness and dominance, the majority of these studies have focused on either the effects of shape information or surface information alone. Consequently, the relative contributions of facial shape and surface characteristics to attractiveness and dominance perceptions are unclear. To address this issue, we investigated the relationships between ratings of original versions of faces and ratings of versions in which either surface information had been standardized (i.e., shape-only versions) or shape information had been standardized (i.e., surface-only versions). For attractiveness and dominance judgments of both male and female faces, ratings of shape-only and surface-only versions independently predicted ratings of the original versions of faces. The correlations between ratings of original and shape-only versions and between ratings of original and surface-only versions differed only in two instances. For male attractiveness, ratings of original versions were more strongly related to ratings of surface-only than shape-only versions, suggesting that surface information is particularly important for men’s facial attractiveness. The opposite was true for female physical dominance, suggesting that shape information is particularly important for women’s facial physical dominance. In summary, our results indicate that both facial shape and surface information contribute to judgments of others’ attractiveness and dominance, suggesting that it may be important to consider both sources of information in research on these topics

Remembrance

https://digitalcommons.library.umaine.edu/mmb-me/1220/thumbnail.jp

Theory of short-range magnetic order for the t-J model

We present a self-consistent theory of magnetic short-range order based on a spin-rotation-invariant slave-boson representation of the 2D t-J model. In the functional-integral scheme, at the nearest-neighbour pair-approximation level, the bosonized t-J Lagrangian is transformed to a classical Heisenberg model with an effective (doping-dependent) exchange interaction which takes into account the interrelation of ``itinerant'' and ``localized'' magnetic behaviour. Evaluating the theory in the saddle-point approximation, we find a suppression of antiferromagnetic and incommensurate spiral long-range-ordered phases in the favour of a paramagnetic phase with pronounced antiferromagnetic short-range correlations.Comment: 2 pages, 1 Postscript figure, LTpaper.sty, Proc. XXI Int. Conf. on Low Temp. Phys. Prague 9

Superconductor-to-Spin-Density-Wave Transition in Quasi-One-Dimensional Metals with Ising Anisotropy

We study a mechanism for superconductivity in quasi-one-dimensional materials with Ising anisotropy. In an isolated chain Ising anisotropy opens a spin gap; if inter-chain coupling is sufficiently weak, single particle hopping is suppressed and the physics of coupled chains is controlled by a competition between pair hopping and exchange interaction. Spin density wave and triplet superconductivity phases are found separated by a first order phase transition. For particular parameter values a second order transition described by SO(4) symmetry is found.Comment: 18 pages, 1 figur

Oaths and Swearing in Ancient Greece

The oath was an institution of fundamental importance across a wide range of social interactions throughout the ancient Greek world, making a crucial contribution to social stability and harmony; yet there has been no comprehensive, dedicated scholarly study of the subject for over a century. This volume of a two-volume study explores the nature of oaths as Greeks perceived it, the ways in which they were used (and sometimes abused) in Greek life and literature, and their inherent binding power

Effects of ADHD on writing composition product and process in school-age students

Objective: This study examined the relationship between ADHD and writing performance. Method: Students in Grades 3 to 7, 84 with ADHD and 135 age and gender-matched controls completed a writing task (including process logs), and measures of, working memory and attention. Results: Students with ADHD wrote texts of similar length but with poorer structure, coherence and ideation. 6.7% of the variance in writing quality was explained by whether or not the student had an ADHD diagnosis, after control for IQ and age-within-year, with students with ADHD producing text that was less coherent, well structured, and ideationally rich and to spend less time thinking about and reviewing their text. Half of the effect on text quality could be attributed to working memory and sustained attention effects. Conclusions: ADHD has some effect on writing performance which can, in part, be explained by working memory and attentional deficits