Methods for complex treatment of children with obstetric paralysis

During childbirth in case of incorrect birth management, pelvio-fetal disproportion, breech or leg presentation, etc. it is possible to damage the Plexus brachialis. Peripheral nerve damage most often occurs during manual fetal retrieval. The trauma leads to compression, stretching or rupture of the brachial /shoulder/ plexus with the resulting consequences: flaccid paresis or paralysis of the muscles of the upper limb of the child with involvement of the peripheral nerves.For several days after birth, the whole arm is paralyzed and difficult to move. Recovery depends on the severity of the damage. With proper and timely treatment, the chance of a full recovery is huge.Our study aims to establish the importance of massage as part of a comprehensive outpatient treatment of children with obstetric paralysis.We used a documentary method, analyzing literature sources examining the subject of the present study and monitoring in a rehabilitation center, where complex treatment was applied. Timely diagnosis and immediate care and rehabilitation, including massage and/ or passive and active kinesitherapy, lead to the appearance of active movements.In order to build the most correct behavior towards the sick child, the parents need to be acquainted with the nature of the disease, the home regime, the nutrition, etc. Conservative therapy and rehabilitation up to the 3rd year are effective, in more severe cases at this age a surgical intervention is most appropriate (2). From the present study we can draw the following conclusions: 1. Massage plays a leading role, especially at an early age. 2. Kinesitherapy is the most important and is the basis of treatment. 3. The parents contribute greatly to the healing process

Computational Perspective on Intricacies of Interactions, Enzyme Dynamics and Solvent Effects in the Catalytic Action of Cyclophilin A

Cyclophilin A (CypA) is the well-studied member of a group of ubiquitous and evolutionarily conserved families of enzymes called peptidyl–prolyl isomerases (PPIases). These enzymes catalyze the cis-trans isomerization of peptidyl-prolyl bond in many proteins. The distinctive functional path triggered by each isomeric state of peptidyl-prolyl bond renders PPIase-catalyzed isomerization a molecular switching mechanism to be used on physiological demand. PPIase activity has been implicated in protein folding, signal transduction, and ion channel gating as well as pathological condition such as cancer, Alzheimer’s, and microbial infections. The more than five order of magnitude speed-up in the rate of peptidyl–prolyl cis–trans isomerization by CypA has been the target of intense research. Normal and accelerated molecular dynamic simulations were carried out to understand the catalytic mechanism of CypA in atomistic details. The results reaffirm transition state stabilization as the main factor in the astonishing enhancement in isomerization rate by enzyme. The ensuing intramolecular polarization, as a result of the loss of pseudo double bond character of the peptide bond at the transition state, was shown to contribute only about −1.0 kcal/mol to stabilizing the transition state. This relatively small contribution demonstrates that routinely used fixed charge classical force fields can reasonably describe these types of biological systems. The computational studies also revealed that the undemanding exchange of the free substrate between β- and α-helical regions is lost in the active site of the enzyme, where it is mainly in the β-region. The resultant relative change in conformational entropy favorably contributes to the free energy of stabilizing the transition state by CypA. The isomerization kinetics is strongly coupled to the enzyme motions while the chemical step and enzyme–substrate dynamics are in turn buckled to solvent fluctuations. The chemical step in the active site of the enzyme is therefore not separated from the fluctuations in the solvent. Of special interest is the nature of catalysis in a more realistic crowded environment, for example, the cell. Enzyme motions in such complicated medium are subjected to different viscosities and hydrodynamic properties, which could have implications for allosteric regulation and function

Viral Quasispecies Reconstruction Using Next Generation Sequencing Reads

The genomic diversity of viral quasispecies is a subject of great interest, especially for chronic infections. Characterization of viral diversity can be addressed by high-throughput sequencing technology (454 Life Sciences, Illumina, SOLiD, Ion Torrent, etc.). Standard assembly software was originally designed for single genome assembly and cannot be used to assemble and estimate the frequency of closely related quasispecies sequences. This work focuses on parsimonious and maximum likelihood models for assembling viral quasispecies and estimating their frequencies from 454 sequencing data. Our methods have been applied to several RNA viruses (HCV, IBV) as well as DNA viruses (HBV), genotyped using 454 Life Sciences amplicon and shotgun methods

The Social Semiotic Analysis of Translation of Joseph Conrad’s Heart of Darkness Based on Peircean Model

The aim of the present article is to investigate the meaning of the signs in Persian translation of Heart of Darkness. To reach the desired goal, the researcher has used social semiotics and Peirce’s triadic sign model as the theoretical framework. In the current study, Peirce semiotics has been used for detecting signs. After detection 50 signs, the researcher used Peirce’s triadic sign model for analyzing the translation of each sign. The researcher decoded the signs to identify their components and analyzed them in social semiotic level to clarify whether they have the same impression on the Persian version of Heart of Darkness as their English source or not. After performing data analysis, it was cleared that 37 signs (out of 50) in the corpus of the study have the same effect and meaning in the target text as what they have in the source text

Grace in Marilynne Robinson's Gilead and Georges Bernanos's The diary of a Country Priest

Marilynne Robinson's Gilead (2007), a meditative letter written by an aging minister, probes the need for forgiveness and grace. George Bernanos's The Diary of a Country Priest (1936) pictures the suffering and sacrifice of an unnamed young priest in his attempt to open his parishioner’s heart to the love of God. Both novelists explore themes such as forgiveness, love, peace, faith, and grace. This paper first discusses the prevalent Christian themes in these novels, and the ways each novelist presents the saving and life-giving power of God's grace in healing and restoring human soul, and then compares their treatment of these issues. The Protestant Robinson's sensibility regarding these religious themes seems very similar to that of the Catholic Bernanos. Indeed, the American writer seems to be considerably influenced by her French predecessor

Liveness Verification in TRSs Using Tree Automata and Termination Analysis

This paper considers verification of the liveness property Live(R, I, G) for a term rewrite system (TRS) R, where I (Initial states) and G (Good states) are two sets of ground terms represented by finite tree automata. Considering I and G, we transform R to a new TRS R' such that termination of R' proves the property Live(R, I, G)

The autobiographical novels of Sidonie-Gabrielle Colette and Virginia Woolf: a comparative study

Autobiographical mode of writing informs the works of many novelists, consciously or unconsciously. There are, however, diverse techniques for formulating these conscious or unconscious autobiographical interpolations in literary works. This essay aims to study the works of Sidonie-Gabreille Colette and Virginia Woolf to trace the nuances of the autobiographical mode in two contemporary female writers from different nations. We do not aim at proving that these two writers deploy the autobiographical mode in their writings, but how similar and different their autobiographical techniques in the creation of fiction are. Therefore, Colette's and Woolf's novels, in general, will be compared and contrasted with an eye on their self-defined strategies for the development of autobiographical fiction

Crustal Imaging With Bayesian Inversion of Teleseismic P Wave Coda Autocorrelation

The autocorrelation of the seismic transmission response of a layered medium(autocorrelogram), in the presence of a free surface, corresponds to the reflection response. Despite manystudies on the imaging of local structures through retrieval and forward modeling of stackedautocorrelograms, there is limited work on the inversion of these data. In this study, we demonstrate thatthe probabilistic inversion of autocorrelograms is efficientand can be used as an alternative imaging toolwhen other approaches are not applicable. Here, we calculate autocorrelograms of teleseismicPwave codarecorded on more than 1,200 permanent and temporary seismic stations across Australia and utilize aBayesian framework to invert these data for crustal imaging. The results show patterns of structuresconsistent with those seen in previous crustal models constructed from receiver function, seismicreflection, and refraction methods. The new approach can therefore image large-scale crustal structurescomparable to those from other seismological methods

Factor structure and validity of Cognitive adjustment as an indicator of psychological health at work

Background and aims: Mental health has been defined as one of the basic principles of psychological health. Mental health along with mental experience of anxiety and calmness should also assess the individual’s performance at work. The main aim of the current study was to carry out factor analysis and validation of the questionnaire for cognitive adjustment at work. Methods: The research scheme utilized by the study is the methodology approach and the study is a Methodological. The statistical population of the study include all the students at Yasouj Medical University, from which 215 participants were selected using the convenient sampling method as the sample of the study. Then, the questionnaire of cognitive adjustment at work, developed by Malo, Tremblay, and Brunet, was distributed among the sample. This scale was translated into Persian and then re-translated into English. Some experts studied the questionnaire to determine the cultural sensitivities, the clarity of questions, the number of differences and errors in meaning construction. Results: The findings showed that Cronbach Alpha coefficient was 0.87 for the whole questionnaire and varied from 0.76 to 0.81 for subscales. All items had acceptable correlation. The test-retest results indicated the stability of the questionnaire of students' attitude toward police and its subscales. The exploratory factor analysis indicated 3 acceptable subscales. Conclusion: The results showed that the Persian version of the work environment cognitive adjustment questionnaire has acceptable reliability and validity. In order to measure working mental health along with the components of psychological health, it can be used the questionnaire with Iranian samples

Effects Of Column Splice Properties On Seismic Demands In Steel Moment Frames

Dynamic inelastic response history analysis of a 2-D model of a nine storey steel frame were carried out with different column splice strengths and stiffnesses using a suite of 20 MCE level earthquake records. Splices were located every 2nd storey at one third of the storey height up from the column below. It was shown that (i) the presence of even very flexible splices increased the frame period by less than 3%, (ii) flexible splices increased storey drift ratios by up to 27%, (iii) splice stiffnesses of zero to infinity had no effect on frame displacements, (iv) the splice moment demand increased with increasing splice stiffness on the frame and was as high as 99% of the column flexural capacity