Assessment of Bone Conduction Thresholds After Surgical Treatment in Patients with Labyrinthine Fistula

Objective: This study aimed to analyze the bone conduction thresholds before and after surgery in chronic otitis media patients with cholesteatoma who had labyrinthine fistula and whose cholesteatoma matrix had been completely cleaned.Methods: The study was performed between 2013 to 2017 with 23 chronic otitis media patients who had labyrinthine fistula with cholesteatoma and who were operated at the Department of Otorhinolaryngology of Dicle University School of Medicine. Patients were assessed by anamnesis and examination and when necessary, by temporal computerized tomography and diffusion magnetic resonance imaging. Bone conduction thresholds at frequencies of 500, 1000, 2000, and 4000 Hz were determined by audiometric examination and they were compared before and after surgery.Results: Of the 23 patients, 12 were female and 11 were male; their age range was 10–55 (26.04±14.13) years. In the post-operative period, it was possible to conduct audiological follow-up on 20 patients. In these follow-ups, 16 patients showed no change in bone conduction thresholds, two patients showed worsening, and two showed improvement. When pre- and post-operative bone conduction thresholds at each frequency were compared separately, no significant difference was found (p=0.937). No statistically significant difference was found between the pre- and post-operative means at the four frequencies (p=0.712).Conclusion: In this study, we found that to reduce complications relating to cholesteatoma, it might be necessary to completely remove the matrix especially in the case of type 1 and 2 labyrinthine fistulas

Çukurova yöresinde yetişen bakla türlerinin hemolitik aktivitesinin saptanması ve izole edilen gligozidlerin ATPaz enzim sistemine olan etkisi

TEZ403Tez (Yüksek Lisans) -- Çukurova Üniversitesi, Adana, 1986.Kaynakça (s. 121-132) var.vii, vxiii, 132 s. ; 30 cm.

Imatinib-induced apoptosis: A possible link to topoisomerase enzyme inhibition

Summary What is known and Objective: Imatinib is a specific BCR/ABL inhibitor, commonly used for the treatment of chronic myeloid leukaemia (CML), a hematological malignancy resulting from a chromosomal translocation that generates the BCR/ABL fusion protein. Recent studies showed that the imatinib has cytotoxic and apoptotic effects on many BCR/ABL-negative cancers. Numerous compounds with cytotoxic potential exert their functions by interfering with the DNA topoisomerase. In this study, we examined the effects of imatinib on tumour cell-killing in relation to DNA topoisomerase enzyme inhibition. Methods: We determined the cytotoxicity by cell proliferation assay (XTT; tetrazolium hydroxide), using the human K562 CML cells, and loss of mitochondrial membrane potential by monitoring the changes in caspase-3 enzyme activity. Type I and II topoisomerase activities were measured by supercoiled plasmid relaxation and minicircle DNA decatenation assays respectively. Results and Discussion: Imatinib-induced apoptosis and inhibited cell proliferation in a dose-dependent manner. We also found that the imatinib was effective in both type I and type II topoisomerase reactions to a varying degree between 94% and 7% for the concentration range of 1 mm-0.02 mm in a dose-dependent manner. What is new and Conclusion: Our results suggest that the inhibition of topoisomerases may be a significant factor in imatinib-induced apoptosis in CML.The Scientific and Technological ResearchCouncil of Turkey (Grant No: TBAG108T548

Germination Performance of Old and New Durum Wheat Species Under Saline Irrigation Conditions

Worldwide, foods produced from wheat constitute the greatest food group consumed by humans. Therefore, wheat production should be increased both to catch up with the current nutritional needs and to meet ever-increasing demands. Irrigation is the most significant input in wheat production. It is quite significant that plant water requirement should be met on time, at proper quantities with quality irrigation water. Current climate change and demands exert serious pressured on water resources. Initially, water resources use should be optimized for sustainability of agricultural production, then low quality waters should also be used after taking relevant remedial measures. Undesired problems may be experienced wen such low quality waters were used in irrigation just based on ion composition and&nbsp; concentrations of these waters. High soluble salt contents of root zone solution negatively influence germination, water and nutrient uptake of plants. Germination is the vital stage in seed-propagated plants. In this study, new and old bread wheat cultivars (Triticum spelta and Triticum aestivum) were sown into petri dishes and germination tests were performed under irrigation waters with different salinity levels (0, 8, 10, 12, 15, 20 ve 30 dS/m) generated with different salt sources. Sodium absorption ratio (SAR) of irrigation waters were all below 3. The greatest germination rates (79%) was obtained from current hexaploid wheat and the lowest values (42%) were obtained from primitive hexaploid wheat. On the other hand, primitive cultivar had greater dry matter yields. In general, germination rates decreased with increasing irrigation water salinity (EC) levels.&nbsp;</p