Characterization of a new epoxy-hydroxycarvotanacetone derivative from the leaf essential oil of Laggera pterodonta from Côte d’Ivoire

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New essential oils with interesting biological activities from endemic plants of Côte d'Ivoire: Zanthoxylum mezoneurispinosum and Zanthoxylum psammophilum

New essential oils with interesting biological activities from endemic plants of Côte d’Ivoire: Zanthoxylum mezoneurispinosum (Ake Assi) and Zanthoxylum psammophilum (Ake Assi). Evelyne A. Tanoh1*, Fatimata Nea1, Tierry K. Kenne2, Manon Genva2, Matthew Saive2, Felix Z. Tonzibo1, Marie-Laure Fauconnier2. 1 Laboratory of Biological Organic Chemistry, UFR-SSMT, University Felix Houphouet-Boigny, BPV 34 Abidjan, Côte d’Ivoire 2 Laboratory of Natural Molecules Chemistry, University of Liège, Gembloux Agro- Bio Tech, 2, Passage of Deportés, B-5030 Gembloux, Belgium According to OMS nearly 80% of the population depend on traditional medicine given the strong growth in the use of natural products from plants1. Many Rutaceae plants are already used in traditional medicine for their biological properties such as anticancer and antioxidant activities. Zanthoxylum mezoneurispinosum (Ake Assi) and Zanthoxylum psammophylum (Ake Assi) are endemic Rutaceae to Côte d’Ivoire. In order to determine if those plants could be used in medicine, the aim of this work was to evaluate the chemical composition and the biological activities of essential oils extracted from both plants. Essential oils of our plants isolated from the leaves, trunk bark and roots. Their chemical compositions were determined by GC-MS. In vitro biological properties were determined using two activities: Antioxidant and anti-inflammatory. The analysis of the essential oils of leaves, trunk bark and roots of Z. psammophylum exhibit the predominance of two unusual methyl ketones, 2-undecanone and 2-tridecanone in leaves and trunk bark. These compounds have biological properties according to the literature2. The root is rich in thymol. Z. mezoneurispinosum oil is rich in alpha pinene for leaves and trunk bark, while the root is rich in gamma-elemene and cyclosativene. Cyclosativene is known for its biological activities3. The essential oils of both plants showed in increasing order antioxidant value in the leaves, trunk bark and roots. A measure of anti-inflammatory activity was found to in decreasing order in the root, followed by leaves and trunk bark. These plants could constitute a source of active molecules for traditional medicine in Côte d'Ivoire. However, although these plants are endemic in this country, they are not abundant and it is necessary to limit and protect the distribution of nurseries to produce plants and reintroduce these species into their natural habitat. References 1- O.M.S, 2002. : Besoins et potentiel. N° 4. 6 p. 2- Saini Mukesh and al, (2014). J. Agric. Food. Chem, 62: 4342 – 4348. 3- Kang Min-Seung, Lee Hoi-Seon, (2018). Applied Biological chemistry 61 (6): pp 653 – 659

Chemical Variability of Ivoirian Xylopia rubescens Leaf Oil

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Chemical Constituents and Antibacterial Activity of Essential Oils from Flowers and Stems of Ageratum conyzoides from Ivory Coast

The essential oils (EOs) obtained by hydro-distillation of flowers and stems of Ageratum conyzoides L. (Asteraceae) growing in Ivory Coast were investigated. The oils were analyzed and characterized by GC and GC MS. Analyses of the EOs led to the identification and quantification of 48 constituents in the flower oil and 44 from the stem oil, respectively. Characterization of the EOs revealed the predominance of 6-demethoxyageratochromene or precocene I (flower: 58.8%, stem: 76.5%) and the sesquiterpene beta-caryophyllene (flower: 15.2%, stem: 8.1%). Six of the identified compounds beta-copaene, hexanal, trans-cadina-1(6),4-diene, alpha-calacorene, caryophylla-4(12),8(13)-diene-5-beta-ol and 1,10-di-epi-cubenol are reported for the first time as constituents of A. conyzoides. Comparative analysis with data from Nigeria, Pakistan, Fiji and Brazil is reported. The antibacterial activity of EOs from of A. conyzoides was tested against seven bacteria. The inhibition zones and minimum inhibitory concentration (MIC) for bacteria strains which were sensitive to A. conyzoides EOs were in the range of 6.7 to 12.7 mm and 64 to 256 mu g/ml, respectively. The EOs showed moderate activity against Staphylococcus aureus and Enterococcus faecalis

Chemical Composition and Evaluation of the Antimicrobial Activity of the Essential Oils from Fruits of Morinda lucida

International audienceThe essential oils (EOs) obtained by hydro-distillation of fruits of Morinda lucida (Rubiaceae) growing in Cote d'Ivoire were investigated. The oil was analyzed and characterized by GC and GC-MS. Analyses of the EOs led to the identification and quantification of 45 constituents. Characterization of the EOs revealed the predominance of (E)-phytol (14.80 %) and n-octanol (6.19 %) followed by beta-caryophyllene (5.54 %) and 6,10,14-trimethyl pentandecan-2-one (5.48 %). The antibacterial activity of EOs from M.lucida was tested against three bacteria Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa using a disc-diffusion method and the minimal inhibitory concentration (MIC) values determined. The inhibition zones and MIC values were in the range of 11.6 to 24.3 mm and 32 to 256 mu g/mL, respectively. The EOs showed good antibacterial activity against S. aureus and P. aeruginosa. The volatile oils extracted from M lucida exhibited a higher activity than the antibiotics tested on P aeruginosa

Chemical Composition and Evaluation of the Antimicrobial Activity of the Essential Oils from Fruits of Morinda lucida

International audienceThe essential oils (EOs) obtained by hydro-distillation of fruits of Morinda lucida (Rubiaceae) growing in Cote d'Ivoire were investigated. The oil was analyzed and characterized by GC and GC-MS. Analyses of the EOs led to the identification and quantification of 45 constituents. Characterization of the EOs revealed the predominance of (E)-phytol (14.80 %) and n-octanol (6.19 %) followed by beta-caryophyllene (5.54 %) and 6,10,14-trimethyl pentandecan-2-one (5.48 %). The antibacterial activity of EOs from M.lucida was tested against three bacteria Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa using a disc-diffusion method and the minimal inhibitory concentration (MIC) values determined. The inhibition zones and MIC values were in the range of 11.6 to 24.3 mm and 32 to 256 mu g/mL, respectively. The EOs showed good antibacterial activity against S. aureus and P. aeruginosa. The volatile oils extracted from M lucida exhibited a higher activity than the antibiotics tested on P aeruginosa