Chandra HETGS Multiphase Spectroscopy Of The Young Magnetic O Star Theta(1) Orionis C

We report on four Chandra grating observations of the oblique magnetic rotator theta(1) Ori C (O5.5 V), covering a wide range of viewing angles with respect to the star\u27s 1060 G dipole magnetic field. We employ line-width and centroid analyses to study the dynamics of the X-ray - emitting plasma in the circumstellar environment, as well as line-ratio diagnostics to constrain the spatial location, and global spectral modeling to constrain the temperature distribution and abundances of the very hot plasma. We investigate these diagnostics as a function of viewing angle and analyze them in conjunction with new MHD simulations of the magnetically channeled wind shock mechanism on theta(1) Ori C. This model fits all the data surprisingly well, predicting the temperature, luminosity, and occultation of the X-ray - emitting plasma with rotation phase

Inhibition of the Nuclear Factor-κB Pathway Prevents Beta Cell Failure and Diet Induced Diabetes in Psammomys obesus

BACKGROUND: High doses of anti-inflammatory drugs, such as aspirin and salicylates, improve glucose metabolism in insulin resistant and type 2 diabetic patients. It has also been shown that the glucose lowering effect is related to the unspecific ability of these drugs to inhibit inhibitor kinaseβ (IKKβ). In this study we have investigated the effect of a selective IKKβ-inhibitor on beta cell survival and the prevention of diet induced type 2 diabetes in the gerbil Psammomys obesus (P. obesus). METHODOLOGY/PRINCIPAL FINDINGS: P. obesus were fed a diabetes inducing high energy diet for one month in the absence or presence of the IKKβ-inhibitor. Body mass, blood glucose, HbA(1C), insulin production and pancreatic insulin stores were measured. The effects on beta cell survival were also studied in INS-1 cells and primary islets. The cells were exposed to IL-1β and subsequently reactive oxygen species, insulin release and cell death were measured in the absence or presence of the IKKβ-inhibitor. In primary islets and beta cells, IL-1β induced the production of reactive oxygen species, reduced insulin production and increased beta cell death, which were all reversed by pre-treatment with the IKKβ-inhibitor. In P. obesus the IKKβ-inhibitor prevented the development of hyperglycaemia and hyperinsulinaemia, and maintained pancreatic insulin stores with no effect on body weight. CONCLUSIONS/SIGNIFICANCE: Inhibition of IKKβ activity prevents diet-induced diabetes in P. obesus and inhibits IL-1β induced reactive oxygen species, loss of insulin production and beta cell death in vitro

Detrimental effect of cardiopulmonary bypass(CPB) on malignant disease

Patients with coronary artery disease associated with malignancy are a difficult group of patients to treat. The ideal approach to manage them is still controversial. Both problems can be manage by either a combined or staged operation. The use of CPB during revascularization of the myocardium among patients with malignant disease, may have an effect on dissimination of malignant cells. This was observed among two of our patients. We believe that the use of off-pump technique to revascularize the myocardium is a safe approach and can be performed either in combined or staged surgery to resect malignant disease

Spectacular X-ray tails, intracluster star formation and ULXs in A3627

We present the discovery of spectacular double X-ray tails associated with ESO137-001 and a possibly heated X-ray tail associated with ESO137-002, both late-type galaxies in the closest rich cluster Abell 3627. A deep Chandra observation of ESO137-001 allows us for the first time to examine the spatial and spectral properties of such X-ray tails in detail. Besides the known bright tail that extends to ~ 80 kpc from ESO137-001, a fainter and narrower secondary tail with a similar length was surprisingly revealed. There is little temperature variation along both tails. We also identified six X-ray point sources as candidates of intracluster ULXs with L(0.3-10 keV) of up to 2.5x10^40 erg s^-1. Gemini spectra of intracluster HII regions downstream of ESO137-001 are also presented, as well as the velocity map of these HII regions that shows the imprint of ESO137-001's disk rotation. For the first time, we unambiguously know that active star formation can happen in the cold ISM stripped by ICM ram pressure and it may contribute a significant amount of the intracluster light. We also report the discovery of a 40 kpc X-ray tail of another late-type galaxy in A3627, ESO137-002. Its X-ray tail seems hot, ~ 2 keV (compared to ~ 0.8 keV for ESO137-001's tails). We conclude that the high pressure environment around these two galaxies is important for their bright X-ray tails and the intracluster star formation.Comment: ApJ in press, January 2010, v708, only several minor word changes, emulateapj5.sty, 24 pages, 11 color + 5 B/W figures (figure quality degraded) and 4 tables. The abstract has been abbreviated. A high-resolution PDF is available at: http://www.astro.virginia.edu/~ms4ar/eso137_p3.pd

The low redshift Lyman-α\alpha Forest as a constraint for models of AGN feedback

We study the low redshift Lyman-$\alpha$ Forest in the Illustris and IllustrisTNG (TNG) cosmological simulations to demonstrate their utility in constraining aspects of sub-grid models of feedback from active galactic nuclei (AGN). The two simulations share an identical Ultraviolet Background prescription and similar cosmological parameters, but TNG features an entirely reworked AGN feedback model. Therefore a comparison of these simulations is useful to assess the effects of an altered AGN sub-grid model on the low redshift Lyman-$\alpha$ Forest. We find significant differences in the IGM temperature-density relation between the two simulations due to changes in the gas heating rate due to AGN. We investigate Lyman-$\alpha$ Forest observables such as the column density distribution function, flux PDF, and Doppler width ($b$-parameter) distribution. Due to the AGN radio mode model, the original Illustris simulations have a factor of 2-3 fewer absorbers than TNG at column densities $N_{\rm HI}< 10^{15.5}$ cm$^{-2}$. We show that TNG is in much better agreement with the observed $z=0.1$ flux power spectrum than Illustris. The differences in the amplitude and shape of the flux PDF and power spectrum between Illustris and TNG cannot be attributed to simple changes in the photoheating rate. We also compare the simulated Forest statistics to UV data from the Cosmic Origins Spectrograph (COS) and find that neither simulation can reproduce the slope of the absorber distribution. Both Illustris and TNG also produce significantly smaller $b$-parameter distributions than observed in the COS data, possibly due to unresolved or missing sources of turbulence.Comment: Submitted to ApJL, comments welcom

Itch and skin rash from chocolate during fluoxetine and sertraline treatment: Case report

BACKGROUND: The skin contains a system for producing serotonin as well as serotonin receptors. Serotonin can also cause pruritus when injected into the skin. SSRI-drugs increase serotonin concentrations and are known to have pruritus and other dermal side effects. CASE PRESENTATION: A 46-year-old man consulted his doctor due to symptoms of depression. He did not suffer from any allergy but drinking red wine caused vasomotor rhinitis. Antidepressive treatment with fluoxetine 20 mg daily was initiated which was successful. After three weeks of treatment an itching rash appeared. An adverse drug reaction (ADR) induced by fluoxetine was suspected and fluoxetine treatment was discontinued. The symptoms disappeared with clemastine and betametasone treatment. Since the depressive symptoms returned sertraline medication was initiated. After approximately two weeks of sertraline treatment he noted an intense itching sensation in his scalp after eating a piece of chocolate cake. The itch spread to the arms, abdomen and legs and the patient treated himself with clemastine and the itch disappeared. He now realised that he had eaten a chocolate cake before this episode and remembered that before the first episode he had had a chocolate mousse dessert. He had never had any reaction from eating chocolate before and therefore reported this observation to his doctor. CONCLUSIONS: This case report suggests that there may be individuals that are very sensitive to increases in serotonin concentrations. Dermal side reactions to SSRI-drugs in these patients may be due to high activity in the serotonergic system at the dermal and epidermo-dermal junctional area rather than a hypersensitivity to the drug molecule itself

Chandra HETGS Multi-Phase Spectroscopy of the Young Magnetic O Star theta^1 Orionis C

We report on four Chandra grating observations of the oblique magnetic rotator theta^1 Ori C (O5.5 V) covering a wide range of viewing angles with respect to the star's 1060 G dipole magnetic field. We employ line-width and centroid analyses to study the dynamics of the X-ray emitting plasma in the circumstellar environment, as well as line-ratio diagnostics to constrain the spatial location, and global spectral modeling to constrain the temperature distribution and abundances of the very hot plasma. We investigate these diagnostics as a function of viewing angle and analyze them in conjunction with new MHD simulations of the magnetically channeled wind shock mechanism on theta^1 Ori C. This model fits all the data surprisingly well, predicting the temperature, luminosity, and occultation of the X-ray emitting plasma with rotation phase.Comment: 52 pages, 14 figures (1 color), 6 tables. To appear in the Astrophysical Journal, 1 August 2005, v628, issue 2. New version corrects e-mail address, figure and table formatting problem

The GALFA-HI Compact Cloud Catalog

We present a catalog of 1964 isolated, compact neutral hydrogen clouds from the Galactic Arecibo L-Band Feed Array Survey Data Release One (GALFA-HI DR1). The clouds were identified by a custom machine-vision algorithm utilizing Difference of Gaussian kernels to search for clouds smaller than 20'. The clouds have velocities typically between |VLSR| = 20-400 km/s, linewidths of 2.5-35 km/s, and column densities ranging from 1 - 35 x 10^18 cm^-2. The distances to the clouds in this catalog may cover several orders of magnitude, so the masses may range from less than a Solar mass for clouds within the Galactic disc, to greater than 10^4 Solar Masses for HVCs at the tip of the Magellanic Stream. To search for trends, we separate the catalog into five populations based on position, velocity, and linewidth: high velocity clouds (HVCs); galaxy candidates; cold low velocity clouds (LVCs); warm, low positive-velocity clouds in the third Galactic Quadrant; and the remaining warm LVCs. The observed HVCs are found to be associated with previously-identified HVC complexes. We do not observe a large population of isolated clouds at high velocities as some models predict. We see evidence for distinct histories at low velocities in detecting populations of clouds corotating with the Galactic disc and a set of clouds that is not corotating.Comment: 34 Pages, 9 Figures, published in ApJ (2012, ApJ, 758, 44), this version has the corrected fluxes and corresponding flux histogram and masse

Environmental Effects in Clusters: Modified Far-Infrared--Radio Relations within Virgo Cluster Galaxies

(abridged) We present a study on the effects of the intracluster medium (ICM) on the interstellar medium (ISM) of 10 Virgo cluster spiral galaxies using {\it Spitzer} far-infrared (FIR) and VLA radio continuum imaging. Relying on the FIR-radio correlation within normal galaxies, we use our infrared data to create model radio maps which we compare to the observed radio images. For 6 of our sample galaxies we find regions along their outer edges that are highly deficient in the radio compared with our models. We believe these observations are the signatures of ICM ram pressure. For NGC 4522 we find the radio deficit region to lie just exterior to a region of high radio polarization and flat radio spectral index, although the total 20 cm radio continuum in this region does not appear strongly enhanced. These characteristics seem consistent for other galaxies with radio polarization data in the literature. The strength of the radio deficit is inversely correlated with the time since peak pressure as inferred from stellar population studies and gas stripping simulations, suggesting the strength of the radio deficit is good indicator of the strength of the current ram pressure. We also find that galaxies having {\it local} radio {\it deficits} appear to have {\it enhanced global} radio fluxes. Our preferred physical picture is that the observed radio deficit regions arise from the ICM wind sweeping away cosmic-ray (CR) electrons and the associated magnetic field, thereby creating synchrotron tails as observed for some of our galaxies. We propose that CR particles are also re-accelerated by ICM-driven shocklets behind the observed radio deficit regions which in turn enhances the remaining radio disk brightness.Comment: 19 pages, 10 figures; Astrophysical Journa