3,552 research outputs found
Bis(thiocyanato-κN)[tris(2-pyridylmethyl)amine-κ4 N,N′,N′′,N′′′]nickel(II) methanol hemisolvate
The title complex, [Ni(NCS)2(C18H18N4)]·0.5CH3OH, consists of two crystallographically distinct complexes and a methanol solvent molecule. The NiII complexes are pseudo-octahedral six-coordinate, with the tris(2-pyridylmethyl)amine (TPA) ligand providing four N atoms and two N-bound thiocyanates providing the final two N atoms. The distances and angles are typical for NiII–TPA complexes. The compound has unit-cell parameters that are surprisingly similar to the previously reported hydrate
Ethyl 2-(4-chloro-2-oxo-2,3-dihydro-1,3-benzothiazol-3-yl)acetate
In the molecule of the title compound, C11H10ClNO3S, the benzene and thiazole rings are oriented at a dihedral angle of 1.25 (3)°. Intramolecular C—H⋯O and C—H⋯Cl interactions result in the formation of two five-membered rings which both adopt envelope conformations
An Experimental and Analytical Investigation of Stirling Space Power Converter Heater Head
NASA has identified the Stirling power converter as a prime candidate for the next generation power system for space applications requiring 60000 hr of operation. To meet this long-term goal, several critical components of the power converter have been analyzed using advanced structural assessment methods. Perhaps the most critical component, because of its geometric complexity and operating environment, is the power converter's heater head. This report describes the life assessment of the heater head which includes the characterization of a viscoplastic material model, the thermal and structural analyses of the heater head, and the interpolation of fatigue and creep test results of a nickel-base superalloy, Udimet 720 LI (Low Inclusions), at several elevated temperatures for life prediction purposes
2-Amino-5,7-bis(4-fluorophenyl)-1′,3′-dimethyl-7,8-dihydrospiro[pyrido[2,3-d]pyrimidine-6(5H),5′-pyrimidine]-2′,4,4′,6′(3H,1′H,3′H,5′H)-tetraone ethanol solvate
In the molecule of the title compound, C24H20F2N6O4·C2H5OH, the pyrimidine ring is oriented at dihedral angles of 42.64 (3) and 62.94 (3)° with respect to the benzene rings, while the dihedral angle between the benzene rings is 74.45 (3)°. The pyridine ring adopts an envelope conformation. In the crystal structure, intermolecular N—H⋯O and O—H⋯N hydrogen bonds link the molecules into a two-dimensional network, forming R
2
2(8) ring motifs. π–π contacts between the pyrimidine and benzene rings [centroid–centroid distances = 3.516 (1) and 3.927 (1) Å] may further stabilize the structure
Topology of biological networks and reliability of information processing
Biological systems rely on robust internal information processing: Survival
depends on highly reproducible dynamics of regulatory processes. Biological
information processing elements, however, are intrinsically noisy (genetic
switches, neurons, etc.). Such noise poses severe stability problems to system
behavior as it tends to desynchronize system dynamics (e.g. via fluctuating
response or transmission time of the elements). Synchronicity in parallel
information processing is not readily sustained in the absence of a central
clock. Here we analyze the influence of topology on synchronicity in networks
of autonomous noisy elements. In numerical and analytical studies we find a
clear distinction between non-reliable and reliable dynamical attractors,
depending on the topology of the circuit. In the reliable cases, synchronicity
is sustained, while in the unreliable scenario, fluctuating responses of single
elements can gradually desynchronize the system, leading to non-reproducible
behavior. We find that the fraction of reliable dynamical attractors strongly
correlates with the underlying circuitry. Our model suggests that the observed
motif structure of biological signaling networks is shaped by the biological
requirement for reproducibility of attractors.Comment: 7 pages, 7 figure
catena-Poly[[[diiodidocadmium(II)]-μ-1-(4-pyridylmethyl)-1H-benzimidazole] methanol hemisolvate]
In the title coordination polymer, {[CdI2(C13H11N3)]·0.5CH4O}n, each CdII center is four-coordinated by two N-atom donors from two 1-(4-pyridylmethyl)-1H-benzimidazole (L) ligands and two iodide anions, forming a tetrahedral coordination geometry. L ligands bridge adjacent CdII ions, generating two crystallographically independent approximately orthogonal one-dimensional chains. The methanol solvent molecule associates with one of the chains via O—H⋯I interactions
TRPA1 mediates changes in heart rate variability and cardiac mechanical function in mice exposed to acrolein
Short-term exposure to ambient air pollution is linked with adverse cardiovascular effects. While previous research focused primarily on particulate matter-induced responses, gaseous air pollutants also contribute to cause short-term cardiovascular effects. Mechanisms underlying such effects have not been adequately described, however the immediate nature of the response suggests involvement of irritant neural activation and downstream autonomic dysfunction. Thus, this study examines the role of TRPA1, an irritant sensory receptor found in the airways, in the cardiac response of mice to acrolein and ozone. Conscious unrestrained wild-type C57BL/6 (WT) and TRPA1 knockout (KO) mice implanted with radiotelemeters were exposed once to 3 ppm acrolein, 0.3 ppm ozone, or filtered air. Heart rate (HR) and electrocardiogram (ECG) were recorded continuously before, during and after exposure. Analysis of ECG morphology, incidence of arrhythmia and heart rate variability (HRV) were performed. Cardiac mechanical function was assessed using a Langendorff perfusion preparation 24 h post-exposure. Acrolein exposure increased HRV independent of HR, as well as incidence of arrhythmia. Acrolein also increased left ventricular developed pressure in WT mice at 24 h post-exposure. Ozone did not produce any changes in cardiac function. Neither gas produced ECG effects, changes in HRV, arrhythmogenesis, or mechanical function in KO mice. These data demonstrate that a single exposure to acrolein causes cardiac dysfunction through TRPA1 activation and autonomic imbalance characterized by a shift toward parasympathetic modulation. Furthermore, it is clear from the lack of ozone effects that although gaseous irritants are capable of eliciting immediate cardiac changes, gas concentration and properties play important roles
2-Chloro-5-methyl-3-nitropyridine
The title compound, C6H5ClN2O2, crystallizes with two independent molecules in the asymmetric unit. Intermolecular C—H⋯O hydrogen bonds stabilize the crystal structure
3-Bromo-9-(4-chlorobenzyl)-9H-carbazole
The title compound, C19H13BrClN, was synthesized by N-alkylation of 4-chloro-1-(chloromethyl)benzene with 3-bromo-9H-carbazole. The carbazole ring system is essentially planar, with a mean deviation of 0.028 Å, and it makes a dihedral angle of 91.2 (3) Å with the plane of the benzene ring
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