As-built design specification for MISMAP

The MISMAP program, which is part of the CLASFYT package, is described. The program is designed to compare classification values with ground truth values for a segment and produce a comparison map and summary table

Program for the transient response of ablating axisymmetric bodies including the effects of shape change

Governing differential equation, boundary conditions for the analysis on which computer program is based, and method of solution of resulting finite difference equations are discussed in the documentation

As-Built design specification for PARPLT

The design and implementation of the PARPLT program are described. The program produces scatter plots of the greenness profile derived parameters alpha, beta, and t sub o computed by the CLASFYG program (alpha being the approximate greenness rise time; beta, the greenness decay time; and t sub o, the spectral crop emergence date). Statistical information concerning the parameters is also computed

As-Built design specification for UNIV4VEC

The UNIV4VEC program which is part of the CLSFYG package is described. This program reads a CLASFYG vector parameter file and converts it to a four channel universal formatted file

Migration statistics relevant for malaria transmission in Senegal derived from mobile phone data and used in an agent-based migration model.

One year of mobile phone location data from Senegal is analysed to determine the characteristics of journeys that result in an overnight stay, and are thus relevant for malaria transmission. Defining the home location of each person as the place of most frequent calls, it is found that approximately 60% of people who spend nights away from home have regular destinations that are repeatedly visited, although only 10% have 3 or more regular destinations. The number of journeys involving overnight stays peaks at a distance of 50 km, although roughly half of such journeys exceed 100 km. Most visits only involve a stay of one or two nights away from home, with just 4% exceeding one week. A new agent-based migration model is introduced, based on a gravity model adapted to represent overnight journeys. Each agent makes journeys involving overnight stays to either regular or random locations, with journey and destination probabilities taken from the mobile phone dataset. Preliminary simulations show that the agent-based model can approximately reproduce the patterns of migration involving overnight stays

Reducing Stigma toward the Transgender Community: An Evaluation of a Humanizing and Perspective-Taking Intervention

Transgender (TG) individuals are an understudied group at high risk of experiencing discrimination and associated adverse mental health outcomes (IOM, 2011). Although many studies demonstrate that contact reduces negative attitudes toward out-groups, few studies have examined the link between contact and attitudes toward the TG community (Hill & Willoughby, 2005; Walchet al., 2012). This study represents one of the first attempts to understand how to effectively reduce stigma toward the TG community. Results indicate that education alone is not enough to change attitudes; in fact, there is some evidence that associating transgenderism with psychopathology may heighten stigma. Consistent with prior research on stigma towards the mentally ill, the current study suggests that both exposure to intimate media depictions of the “other” (Reinke et al., 2004) and perspective-taking (Mann & Himelein, 2008) could strengthen educational campaigns designed to combat stigma

Development of a Priest interferometer for measurement of the thermal expansion of a graphite epoxy in the temperature range 116-366 K

The thermal expansion behavior of graphite epoxy laminates between 116 and 366 degrees Kelvin was investigated using as implementation of the Priest interferometer concept. The design, construction and use of the interferometer along with the experimental results it was used to generate are described. The experimental program consisted of 25 tests on 25.4 mm and 6.35 mm wide, 8 ply pi/4 quasi-isotropic T300-5208 graphite/epoxy specimens and 3 tests on a 25.4 mm wide unidirectional specimen. Experimental results are presented for all tests along with a discussion of the interferometer's limitations and some possible improvements in its design

Thermal expansion of graphite-epoxy between 116 K and 366 K

A Priest laser interferometer was developed to measure the thermal strain of composite laminates. The salient features of this interferometer are that: (1) it operates between 116 K and 366 K; (2) it is easy to operate; (3) minimum specimen preparation is required; (4) coefficients of thermal expansion in the range of 0-5 micro epsilon/K can be measured; and (5) the resolution of thermal strain is on the order of micro epsilon. The thermal response of quasi-isotropic, T300/5208, grahite-epoxy composite material was studied with this interferometer. The study showed that: (1) for the material tested, thermal cycling effects are negligible; (2) variability of thermal response from specimen to specimen may become significant at cryogenic temperatures; and (3) the thermal response of 0.6 cm and 2.5 cm wide specimens are the same above room temperature

Oregon Psychologists on Prescriptive Authority: Divided Views and Little Knowledge

With over half of all states having considered legislating prescriptive authority, an immense amount of time and money has been invested. The literature is limited in terms of understanding if opinions toward prescriptive authority are grounded in knowledge and what implications that has for altering these opinions. Following a veto of a prescriptive authority bill in Oregon, 399 licensed Oregon clinical psychologists were surveyed regarding their attitudes and knowledge. In terms of knowledge, only 6.5% knew which three states/territories currently have prescriptive authority and 70.4% were unfamiliar with any of the prerequisites for postdoctoral training in psychopharmacology. Reflecting division, 43.4% were in favor, 25.4% were undecided, and 31.2% were in opposition to broadening privileges for psychologists. Further, only 15.2% expressed interest in pursuing training or 6.7% in becoming prescribers. Data on access, training, and legislative costs were presented to participants in the education condition. These participants showed significant gains in their knowledge across all domains and their opinions shifted only in these specific areas leaving their general stance on the issue unchanged. In contrast to ardent supporters who argue that their “data should provide reassurance to psychologists spearheading legislative initiatives” because of high approval ratings (Sammons et al., 2000, p. 608), our data suggest disagreement amongst a group of professionals who are not particularly well-informed, nor interested in becoming prescribers. Future work should investigate whether expanding the data relevant to other facets of the argument contributes to further targeted change or an overall change in opinion toward prescriptive authority

SILAM for quantitative proteomics of liver Akt1/PKBα after burn injury

Akt1/protein kinase Bα (Akt1/PKBα) is a downstream mediator of the insulin signaling system. In this study we explored mechanism(s) for its role in burn injury. Akt1/PKBα in liver extracts from mice with burn injury fed with (2H7)-L-Leu was immunoprecipitated and isolated with SDS-PAGE. Two tryptic peptides, one in the kinase loop and a control peptide just outside of the loop were sequenced via nano-LC interfaced with quadruple time-of-flight tandem mass spectrometry (Q-TOF tandem MS). Their relative isotopologue abundances were determined by stable isotope labeling by amino acids in mammalians (SILAM). Relative quantifications based on paired heavy/light peptides were obtained in 3 steps. The first step included homogenization of mixtures of equal amounts of tissue from burned and sham-treated animals (i.e., isotope dilution) and acquisition of uncorrected data based on parent monoisotopic MS ion ratios. The second step included determination of isotopic enrichment of the kinase from burned mice on Day 7 and the third step enrichment correction of partially labeled heavy and light monoisotopic MS ion ratios for relative quantification of bioactivity (loop peptide) and expression level (control peptide). Protein synthesis and enrichment after injury were found to be dependent on tissue and turnover of individual proteins. Three heavy and light monoisotopic ion ratios for albumin peptides from burned mice indicated ~55% enrichment and ~16.7-fold downregulation. In contract, serum amyloid P had ~66% enrichment and was significantly upregulated. Akt1/PKBα had ~56% enrichment and kinase level in response to the burn injury was upregulated compared with the control peptide. However, kinase bioactivity, represented by the Cys296 peptide, was significantly reduced. Overall, we demonstrated that i) quantitative proteomics can be performed without completely labeled mice; ii) measurement of enrichment of acyl-tRNAs is unnecessary and iii) Cys296 plays an important role in kinase activity after burn injury