Internal and External Factors Associated with Illicit Prescription Drug Use in College Students

With data suggesting emerging adulthood is a time of increased risk for illicit prescription drug use, it is essential that factors contributing to this be understood to guide prevention efforts. Internal factors (stress, GPA, gender) and external factors (type of institution, living situation) were assessed in tandem with perceptions of harm and illicit prescription drug use. In accordance with nationwide research (SAMSHA, 2006), 14% of our sample of Oregon college students reported illicitly using prescription drugs. While rates of use did not vary by gender, females held higher perceptions of harm. Perceived harm was high for our sample and inversely correlated with use. Those living on campus reported higher perceptions of harm and less use than those living off campus. Those attending private academic institutions reported higher perceptions of harm and less use than those attending public institutions. Previous studies suggest a heightened sense of community within schools, comparatively present within private institutions, can reduce drug use (Battistich, & Hom, 1997). Stress was positively correlated with use and GPA was negatively correlated with use. While numerous studies have examined various correlates of prescription drug use, few have sampled beyond a single institution, most within public universities. Thus, the inclusion of private institutions offers unique and a more holistic insight. As drug use continues to increase in college populations even with prevention programs in place, it is imperative to translate these findings into prevention targeting both genders, at times of stress, particularly those living off campus, at public universities, with lower GPAs

As-Built design specification for UNIV4VEC

The UNIV4VEC program which is part of the CLSFYG package is described. This program reads a CLASFYG vector parameter file and converts it to a four channel universal formatted file

In the Wake of a Veto: What Do Oregon Psychologists Think and Know about Prescription Privileges for Psychologists?

Clinical psychology continues to grapple with a contentious debate surrounding prescriptive authority. With over half of all states having considered legislating prescriptive authority, an immense amount of time and money has been invested. This study aims to assess knowledge and attitudes of licensed psychologists in Oregon following a veto that prevented it from becoming the third state with prescription privileges for psychologists. From a list of 1,318 licensed Oregon clinical psychologists, 60% were randomly selected to participate. Of the 130 participants invited thus far, 83 have completed the survey, yielding a respectable response rate (64%). Perceived familiarity with current training models revealed lacking awareness with 75.2% and 72% expressing they were not familiar with the DOD and APA models, respectively. Only 5% knew which three states/territories currently have prescriptive authority and 77% were unfamiliar with any of the three prerequisites for postdoctoral training in psychopharmacology. Arguments in favor of prescription privileges garnering the most support related to perceptions of improved access and treatment enhancement. In contrast, the strongest arguments against prescription privileges involved professional issues (e.g., altered identity). Reflecting division, 43.9% were in favor, 20.7% were undecided, and 36% were in opposition to broadening privileges for psychologists. However, only 15.9% expressed interest in completing training and only 7.2% plan to pursue training and become a prescriber. Overall, these findings suggest legislative efforts should be mindful of the controversy within the field and the low numbers of professionals interested in pursuing prescription privileges, which undercut arguments for improved access and care

As-Built design specification for PARPLT

The design and implementation of the PARPLT program are described. The program produces scatter plots of the greenness profile derived parameters alpha, beta, and t sub o computed by the CLASFYG program (alpha being the approximate greenness rise time; beta, the greenness decay time; and t sub o, the spectral crop emergence date). Statistical information concerning the parameters is also computed

A prognostic parameterization for the subgrid-scale variability of water vapor and clouds in large-scale models and its use to diagnose cloud cover

A parameterization for the horizontal subgrid-scale variability of water vapor and cloud condensate is introduced, which is used to diagnose cloud fraction in the spirit of statistically based cloud cover parameterizations. High-resolution cloud- resolving model data from tropical deep convective scenarios were used to justify the choice of probability density function (PDF). The PDF selected has the advantage of being bounded above and below, avoiding the complications of negative or infinite water mixing ratios, and can give both negatively and positively skewed functions as well as symmetric Gaussian-like bell-shaped curves, without discrete transitions, and is mathematically straightforward to implement. A development from previous statistical parameterizations is that the new scheme is prognostic, with processes such as deep convection, turbulence, and microphysics directly affecting the distribution of higher-order moments of variance and skewness. The scheme is able to represent the growth and decay of cirrus cloud decks and also the creation of cloud in clear sky or breakup of an overcast cloud deck by boundary layer turbulence. After introducing the mathematical framework, results using the parameterization in a climate model are shown to illustrate its behavior. The parameterization is shown to reduce cloud cover biases almost globally, with a marked improvement in the stratocumulus regions in the eastern Pacific and Atlantic Oceans

Data-Driven Change in Oregon Psychologists’ Knowledge and Attitudes about Prescriptive Authority

With over half of all states having considered legislating prescriptive authority, an immense amount of time and money has been invested. The literature is limited in terms of understanding if opinions toward prescriptive authority are grounded in knowledge and what implications that has for altering these opinions. Following a veto of a prescriptive authority bill in Oregon, 160 licensed Oregon clinical psychologists were surveyed regarding their attitudes and knowledge. In terms of knowledge, only 5.6% knew which three states/territories currently have prescriptive authority and 70.4% were unfamiliar with any of the prerequisites for postdoctoral training in psychopharmacology. Reflecting division, 42.8% were in favor, 20.1% were undecided, and 37.1% were in opposition to broadening privileges for psychologists. Further, only 15.1% expressed interest in pursuing training or 6.4% in becoming a prescriber. Data on access, training, and legislative costs were presented to participants in the education condition. These participants showed significant gains in their knowledge across all domains and their opinions shifted only in these specific areas leaving their general stance on the issue unchanged. In contrast to ardent supporters who argue that their “data should provide reassurance to psychologists spearheading legislative initiatives” because of high approval ratings (Sammons et al., 2000, p. 608), our data suggest disagreement amongst a group of professionals who are not particularly well-informed, nor interested in becoming prescribers. Future work should investigate whether expanding the data relevant to other facets of the argument contributes to further targeted change or an overall change in opinion toward prescriptive authority

As-built design specification for MISMAP

The MISMAP program, which is part of the CLASFYT package, is described. The program is designed to compare classification values with ground truth values for a segment and produce a comparison map and summary table

CD4+CD25+ T regulatory cells from FIV+ cats induce a unique anergic profile in CD8+ lymphocyte targets

Abstract Background Using the FIV model, we reported previously that CD4+CD25+ T regulatory (Treg) cells from FIV+ cats are constitutively activated and suppress CD4+CD25- and CD8+ T cell immune responses. In an effort to further explore Treg-mediated suppression, we asked whether Treg cells induce anergy through the alteration of production of cyclins, cyclin-dependent kinases and their inhibitors. Results Lymphocytes were obtained from control or FIV+ cats and sorted by FACS into CD4+CD25+ and CD8+ populations. Following co-culture with CD4+CD25+ cells, CD8+ targets were examined by Western blot for changes in cyclins D3, E and A, retinoblastoma (Rb) protein, as well as the cyclin dependent kinase inhibitor p21cip1. Following co-culture with CD4+CD25+cells, we observed up-regulation of p21cip1 and cyclin E, with down-regulation of cyclin D3, in CD8+ cells from FIV+ cats. As expected, CD8+ targets from control cats were quiescent with little up-regulation of p21cip1 and cyclin E. There was also a lack of Rb phosphorylation in CD8+ targets consistent with late G1 cell cycle arrest. Further, IL-2 mRNA was down regulated in CD8+ cells after co-culture with CD4+CD25+ Treg cells. Following CD4+CD25+ co-culture, CD8+ targets from FIV+ cats also had increased Foxp3 mRNA expression; however, these CD8+Foxp3+ cells did not exhibit suppressor function. Conclusions Collectively, these data suggest that CD4+CD25+ Treg cells from FIV+ cats induce CD8+ anergy by disruption of normal G1 to S cell cycle progression.</p

Different thresholds of T cell activation regulate FIV infection of CD4+CD25+ and CD4+CD25− cells

AbstractCellular activation plays an important role in retroviral replication. Previously, we have shown that CD4+CD25+ T cells by the virtue of their partially activated phenotype represent ideal candidates for a productive feline immunodeficiency virus (FIV) infection. In the present study, we extended our previous observations with regard to FIV replication in CD4+CD25+ and CD4+CD25− cells under different stimulation conditions. Both CD4+CD25+ and CD4+CD25− cells remain latently infected in the absence of IL-2 or concanvalinA (ConA), respectively; harboring a replication competent provirus capable of reactivation several days post-infection. While CD4+CD25+ cells require low levels of exogenous IL-2 and virus inputs for an efficient FIV replication, CD4+CD25− T cells can only be productively infected in the presence of either high concentrations of IL-2 or high virus titers, even in the absence of mitogenic stimulation. Interestingly, while high virus input activates CD4+CD25− cells to replicate FIV, it induces apoptosis in a high percentage of CD4+CD25+ T cells. High IL-2 concentrations but not high virus inputs lead to surface upregulation of CD25 and significant cellular proliferation in CD4+CD25− cells. These results suggest that CD4+CD25+ and CD4+CD25− T cells have different activation requirements which can be modulated by both viral and cytokine stimuli to reach threshold activation levels in order to harbor a productive FIV infection. This holds implications in vivo for CD4+CD25+ and CD4+CD25− cells to serve as potential reservoirs of a productive and latent FIV infection