Regiospecific Profiles of Fatty Acids in Triacylglycerols and Phospholipids from Adzuki Beans (Vigna angularis)

Regiospecific distributions of fatty acids (FA) of triacylglycerols (TAG) and phospholipids (PL) isolated from five cultivars of adzuki beans (Vigna angularis) were investigated. The lipids comprised mainly PL (72.2-73.4 wt-%) and TAG (20.6-21.9 wt-%), whilst other components were detected in minor proportions (0.1-3.4 wt-%). The principal profiles of the FA distribution in the TAG and PL were evident in the beans among the five cultivars: unsaturated FA were predominantly distributed in the sn-2 position, whilst saturated FA primarily occupied the sn-1 or the sn-3 position in the these lipids. The results would be useful information to both producers and consumers for manufacturing traditional adzuki confectionaries such as wagashi in Japan

Advanced gastrointestinal stromal tumor with intracerebral hemorrhage during sunitinib treatment\n

　Herein, a 70-year-old female was initially treated with sunitinib 50 mg/day to treat an imatinib-resistant gastrointestinal stromal tumor. After sunitinib initiation, nausea, hypertension, hepatic dysfunction, anorexia, fatigue, thrombocytopenia, epistaxis, and palmoplantar erythrodysesthesia syndrome developed; the dose was reduced to 25 mg/day.　Subsequently, adverse events improved, and from the fifth course onward, sunitinib 37.5 mg/day was continued. Approximately 11 months after initiating sunitinib therapy, the patient developed disturbance of consciousness, aphasia, and left hemiplegia. Computed tomography of the head revealed intracerebral hemorrhage, and the patient was hospitalized. No brain metastases, cerebral aneurysms, or cerebral arteriovenous malformations were observed. Sunitinib-induced hypertensive cerebral hemorrhage was suspected as the cause of intracerebral hemorrhage. Conservative treatments, such as antihypertensive drugs, were administered without surgical treatment. The symptoms and intracerebral hemorrhage gradually improved, and the patient was discharged from the hospital. Intracerebral hemorrhage with sunitinib is extremely rare, but has a high mortality rate. During sunitinib treatment, controlling blood pressure and thrombocytopenia is important to prevent bleeding

Real-time human motion analysis and grasping force using the OptiTrack system and Flexi-force sensor

Biologically inspired robotic hands have important applications in industry and biomedical robotics. The grasping capacity of robotic hands is crucial for a robotic system. This paper presents an experimental study on the finger force and movements of a human hand during the grasping operation in real-time. It focuses on two topics; measuring grasping force using Flexi-force sensors and analysing human hand action during grasping operation. The findings show that lifting required higher forces compared with grasp force in the static phase

Application of deep learning (3-dimensional convolutional neural network) for the prediction of pathological invasiveness in lung adenocarcinoma

To compare results for radiological prediction of pathological invasiveness in lung adenocarcinoma between radiologists and a deep learning (DL) system.Ninety patients (50 men, 40 women; mean age, 66 years; range, 40-88 years) who underwent pre-operative chest computed tomography (CT) with 0.625-mm slice thickness were included in this retrospective study. Twenty-four cases of adenocarcinoma in situ (AIS), 20 cases of minimally invasive adenocarcinoma (MIA), and 46 cases of invasive adenocarcinoma (IVA) were pathologically diagnosed. Three radiologists of different levels of experience diagnosed each nodule by using previously documented CT findings to predict pathological invasiveness. DL was structured using a 3-dimensional (3D) convolutional neural network (3D-CNN) constructed with 2 successive pairs of convolution and max-pooling layers, and 2 fully connected layers. The output layer comprises 3 nodes to recognize the 3 conditions of adenocarcinoma (AIS, MIA, and IVA) or 2 nodes for 2 conditions (AIS and MIA/IVA). Results from DL and the 3 radiologists were statistically compared.No significant differences in pathological diagnostic accuracy rates were seen between DL and the 3 radiologists (P>. 11). Receiver operating characteristic analysis demonstrated that area under the curve for DL (0.712) was almost the same as that for the radiologist with extensive experience (0.714; P=. 98). Compared with the consensus results from radiologists, DL offered significantly inferior sensitivity (P=. 0005), but significantly superior specificity (P=. 02).Despite the small training data set, diagnostic performance of DL was almost the same as the radiologist with extensive experience. In particular, DL provided higher specificity than radiologists

Mg-chelatase H subunit affects ABA signaling in stomatal guard cells, but is not an ABA receptor in Arabidopsis thaliana

Mg-chelatase H subunit (CHLH) is a multifunctional protein involved in chlorophyll synthesis, plastid-to-nucleus retrograde signaling, and ABA perception. However, whether CHLH acts as an actual ABA receptor remains controversial. Here we present evidence that CHLH affects ABA signaling in stomatal guard cells but is not itself an ABA receptor. We screened ethyl methanesulfonate-treated Arabidopsis thaliana plants with a focus on stomatal aperture-dependent water loss in detached leaves and isolated a rapid transpiration in detached leaves 1 (rtl1) mutant that we identified as a novel missense mutant of CHLH. The rtl1 and CHLH RNAi plants showed phenotypes in which stomatal movements were insensitive to ABA, while the rtl1 phenotype showed normal sensitivity to ABA with respect to seed germination and root growth. ABA-binding analyses using 3H-labeled ABA revealed that recombinant CHLH did not bind ABA, but recombinant pyrabactin resistance 1, a reliable ABA receptor used as a control, showed specific binding. Moreover, we found that the rtl1 mutant showed ABA-induced stomatal closure when a high concentration of extracellular Ca2+ was present and that a knockout mutant of Mg-chelatase I subunit (chli1) showed the same ABA-insensitive phenotype as rtl1. These results suggest that the Mg-chelatase complex as a whole affects the ABA-signaling pathway for stomatal movements

Lifting Galois representations over arbitrary number fields

It is proved that every two-dimensional residual Galois representation of the absolute Galois group of an arbitrary number field lifts to a characteristic zero p-adic representation, if local lifting problems at places above p are unobstructed