Magnetická stavba, tok magmatu a tektonická deformace ve vulkano-plutonických systémech

Magnetic fabric, magma flow and tectonic deformation in volcano-plutonic systems ABSTRACT This Ph.D. thesis aims to investigate dynamics of emplacement and tectonic history of selected volcano-plutonic complexes in a continental magmatic arc and back arc setting. The thesis presents new data sets from five field areas, presented in separate chapters, which could be viewed as representing a vertical sections through upper part of an intermediate to felsic magmatic system. From top to bottom in this ‛imaginary' vertical system, the examined units are: (1) andesitic lava domes and (2) sub-volcanic magma chambers (<3 km deep) of the Miocene Štiavnica volcano- plutonic complex, Western Carpathians (Slovakia), (3) Shellenbarger pluton (<3 km depth) within the mid-Cretaceous Minarets caldera, Sierra Nevada batholith in California (USA), and ~7-10 km deep granitoids of (4) Lower-Cretaceous Wallowa batholith, Blue Mountains province in Oregon (USA) and (5) Late Devonian Staré Sedlo complex, central Bohemian Massif (Czech Republic). The research incorporates extensive field and structural data, supported by analysis of igneous textures and anisotropy of magnetic susceptibility (AMS). The latter is further accompanied by detailed examination of magnetic mineralogy using thermomagnetic measurements and optical and back...Magnetická stavba, tok magmatu a tektonická deformace ve vulkano-plutonických systémech ABSTRAKT Cílem této doktorské práce je výzkum dynamiky vmístění a historie tektonické deformace ve vybraných vulkano-plutonických komplexech v prostředí kontinentálních magmatických oblouků a zaobloukových oblastí. Práce prezentuje nová data z pěti terénních případových studií, které mohou být považovány za vertikální řezy svrchní částí intermediárního až felzického magmatického systému. Zkoumané jednotky tohoto pomyslného systému představují samostatné kapitoly a od povrchu do hloubky zahrnují: (1) andesitové lávové dómy a (2) sub-vulkanické magmatické komory (hloubka <3 km) z miocenního štiavnického vulkano-plutonického komplexu v Západních Karpatech (Slovensko), (3) Shellenbarger pluton (hloubka <3 km) uvnitř středně-křídové Minarets kaldery, Sierra Nevada batolit v Kalifornii (USA); a ~7-10 km hluboké granitoidy (4) spodně-křídového Wallowa batolitu, provincie Blue Mountains v Oregonu (USA) a (5) svrchně-devonský starosedelský komplex v centrální část Českého masívu (Česká republika). Samotný výzkum zahrnuje rozsáhlá terénní a strukturní data, která jsou podpořená analýzou magmatických textur a anizotropie magnetické susceptibility (AMS), která je dále doplněna o podrobnou analýzu magnetické mineralogie pomocí...Institute of Geology and PaleontologyÚstav geologie a paleontologieFaculty of SciencePřírodovědecká fakult

Phenotype-dependent apoptosis signalling in mesothelioma cells after selenite exposure

<p>Abstract</p> <p>Background</p> <p>Selenite is a promising anticancer agent which has been shown to induce apoptosis in malignant mesothelioma cells in a phenotype-dependent manner, where cells of the chemoresistant sarcomatoid phenotype are more sensitive.</p> <p>Methods</p> <p>In this paper, we investigate the apoptosis signalling mechanisms in sarcomatoid and epithelioid mesothelioma cells after selenite treatment. Apoptosis was measured with the Annexin-PI assay. The mitochondrial membrane potential, the expression of Bax, Bcl-XL, and the activation of caspase-3 were assayed with flow cytometry and a cytokeratin 18 cleavage assay. Signalling through JNK, p38, p53, and cathepsins B, D, and E was investigated with chemical inhibitors. Furthermore, the expression, nuclear translocation and DNA-binding activity of p53 was investigated using ICC, EMSA and the monitoring of p21 expression as a downstream event. Levels of thioredoxin (Trx) were measured by ELISA.</p> <p>Results</p> <p>In both cell lines, 10 μM selenite caused apoptosis and a marked loss of mitochondrial membrane potential. Bax was up-regulated only in the sarcomatoid cell line, while the epithelioid cell line down-regulated Bcl-XL and showed greater caspase-3 activation. Nuclear translocation of p53 was seen in both cell lines, but very little p21 expression was induced. Chemical inhibition of p53 did not protect the cells from apoptosis. p53 lost its DNA binding ability after selenite treatment and was enriched in an inactive form. Levels of thioredoxin decreased after selenite treatment. Chemical inhibition of MAP kinases and cathepsins showed that p38 and cathepsin B had some mediatory effect while JNK had an anti-apoptotic role.</p> <p>Conclusion</p> <p>We delineate pathways of apoptosis signalling in response to selenite, showing differences between epithelioid and sarcomatoid mesothelioma cells. These differences may partly explain why sarcomatoid cells are more sensitive to selenite.</p

Magnetic fabric, magma flow and tectonic deformation in volcano-plutonic systems

Magnetic fabric, magma flow and tectonic deformation in volcano-plutonic systems ABSTRACT This Ph.D. thesis aims to investigate dynamics of emplacement and tectonic history of selected volcano-plutonic complexes in a continental magmatic arc and back arc setting. The thesis presents new data sets from five field areas, presented in separate chapters, which could be viewed as representing a vertical sections through upper part of an intermediate to felsic magmatic system. From top to bottom in this ‛imaginary' vertical system, the examined units are: (1) andesitic lava domes and (2) sub-volcanic magma chambers (<3 km deep) of the Miocene Štiavnica volcano- plutonic complex, Western Carpathians (Slovakia), (3) Shellenbarger pluton (<3 km depth) within the mid-Cretaceous Minarets caldera, Sierra Nevada batholith in California (USA), and ~7-10 km deep granitoids of (4) Lower-Cretaceous Wallowa batholith, Blue Mountains province in Oregon (USA) and (5) Late Devonian Staré Sedlo complex, central Bohemian Massif (Czech Republic). The research incorporates extensive field and structural data, supported by analysis of igneous textures and anisotropy of magnetic susceptibility (AMS). The latter is further accompanied by detailed examination of magnetic mineralogy using thermomagnetic measurements and optical and back..

Magnetic fabric, magma flow and tectonic deformation in volcano-plutonic systems

Magnetic fabric, magma flow and tectonic deformation in volcano-plutonic systems ABSTRACT This Ph.D. thesis aims to investigate dynamics of emplacement and tectonic history of selected volcano-plutonic complexes in a continental magmatic arc and back arc setting. The thesis presents new data sets from five field areas, presented in separate chapters, which could be viewed as representing a vertical sections through upper part of an intermediate to felsic magmatic system. From top to bottom in this ‛imaginary' vertical system, the examined units are: (1) andesitic lava domes and (2) sub-volcanic magma chambers (<3 km deep) of the Miocene Štiavnica volcano- plutonic complex, Western Carpathians (Slovakia), (3) Shellenbarger pluton (<3 km depth) within the mid-Cretaceous Minarets caldera, Sierra Nevada batholith in California (USA), and ~7-10 km deep granitoids of (4) Lower-Cretaceous Wallowa batholith, Blue Mountains province in Oregon (USA) and (5) Late Devonian Staré Sedlo complex, central Bohemian Massif (Czech Republic). The research incorporates extensive field and structural data, supported by analysis of igneous textures and anisotropy of magnetic susceptibility (AMS). The latter is further accompanied by detailed examination of magnetic mineralogy using thermomagnetic measurements and optical and back..

The Late Devonian to early Carboniferous kinematic evolution of the Teplá-Barrandian/Moldanubian boundary

ENGLISH ABSTRACT The Late Devonian to Early Carboniferous kinematic evolution of the Teplá-Barrandian/Moldanubian boundary The Staré Sedlo complex (SSC) is a relic of meta-igneous arc-related pluton in the southern part of the Sedlčany-Krásná Hora roof pendant, intruded by granitoids of the Central Bohemian Plutonic Complex along the boundary of Teplá-Barrandian (TBU) and Moldanubian units (MU), Bohemian Massif. The SSC mainly comprises deformed orthogneisses of calc-alkaline granodiorite to tonalite protoliths of Late Devonian age (380−365 Ma; Košler et al., 1993) that were commonly mingled with minor basic magmas. Locally preserved subhorizontal intrusive contacts of the orthogneisses against their meta-sedimentary host rock indicate that these magmas intruded as a sill complex. The SSC preserves a rather unusual flat-lying subsolidus foliation (dip <40ř) associated with subhorizontal ~NE-SW-trending mineral lineation. Mesoscopic structures, anisotropy of magnetic susceptibility (AMS), and deformational microstructures indicate prolate shape of the strain ellipsoid with dominant coaxial pure shear regime. The solid state microstructures record cooling of the orthogneiss protolith down to the ambient greenschist facies conditions followed by its static recrystallization due to the intrusion of the younger..

The Late Devonian to early Carboniferous kinematic evolution of the Teplá-Barrandian/Moldanubian boundary

ENGLISH ABSTRACT The Late Devonian to Early Carboniferous kinematic evolution of the Teplá-Barrandian/Moldanubian boundary The Staré Sedlo complex (SSC) is a relic of meta-igneous arc-related pluton in the southern part of the Sedlčany-Krásná Hora roof pendant, intruded by granitoids of the Central Bohemian Plutonic Complex along the boundary of Teplá-Barrandian (TBU) and Moldanubian units (MU), Bohemian Massif. The SSC mainly comprises deformed orthogneisses of calc-alkaline granodiorite to tonalite protoliths of Late Devonian age (380−365 Ma; Košler et al., 1993) that were commonly mingled with minor basic magmas. Locally preserved subhorizontal intrusive contacts of the orthogneisses against their meta-sedimentary host rock indicate that these magmas intruded as a sill complex. The SSC preserves a rather unusual flat-lying subsolidus foliation (dip <40ř) associated with subhorizontal ~NE-SW-trending mineral lineation. Mesoscopic structures, anisotropy of magnetic susceptibility (AMS), and deformational microstructures indicate prolate shape of the strain ellipsoid with dominant coaxial pure shear regime. The solid state microstructures record cooling of the orthogneiss protolith down to the ambient greenschist facies conditions followed by its static recrystallization due to the intrusion of the younger..

The Late Devonian to early Carboniferous kinematic evolution of the Teplá-Barrandian/Moldanubian boundary

ČESKÝ ABSTRAKT KINEMATICKÝ VÝVOJ ROZHRANÍ TEPELSKO-BARRANDIENSKÉ JEDNOTKY A MOLDANUBIKA BĚHEM SVRCHNÍHO DEVONU A SPODNÍHO KARBONU Starosedelský komplex (SSC) představuje relikt metagranitoidů magmatického oblouku v jižní části sedlčansko-krásnohorského metamorfovaného ostrova, který je obklopen granitoidy středočeského plutonického komplexu na rozhraní tepelsko-barrandienské jednotky (TBJ) a moldanubika (MJ) v Českém masívu. SSC zahrnuje především deformované ortoruly, jejichž vápenato-alkalický protolit granodioritu až tonalitu svrchnoddevonského stáří (Košler et al., 1993) byl často mechanicky mísen s méně zastoupenými bazičtějšími magmaty. Lokálně zachované subhorizontální intruzívní kontakty ortorul s jejich okolním metasedimentárním pláštěm naznačují, že tato magmata intrudovala v podobě generelně ploše uloženého žilného komplexu. V SSC se zachovaly ploché subsolidové foliace (sklon &lt;40ř) a subhorizontální ~SV-JZ orientované minerální lineace. Studium mezoskopických staveb, anizotropie magnetické susceptibility (AMS) a analýza mikrostruktur odhalily konstrikční tvar deformačního elipsoidu s dominancí koaxiálního čistého střihu. Stupeň regionální metamorfózy byl odhadnut na podmínky facie zelených břidlic, hloubka vmístění SCC byla tedy odhadnuta na 10 až 12 km. S ohledem na výše zmíněná fakta navrhuji,...ENGLISH ABSTRACT The Late Devonian to Early Carboniferous kinematic evolution of the Teplá-Barrandian/Moldanubian boundary The Staré Sedlo complex (SSC) is a relic of meta-igneous arc-related pluton in the southern part of the Sedlčany-Krásná Hora roof pendant, intruded by granitoids of the Central Bohemian Plutonic Complex along the boundary of Teplá-Barrandian (TBU) and Moldanubian units (MU), Bohemian Massif. The SSC mainly comprises deformed orthogneisses of calc-alkaline granodiorite to tonalite protoliths of Late Devonian age (380−365 Ma; Košler et al., 1993) that were commonly mingled with minor basic magmas. Locally preserved subhorizontal intrusive contacts of the orthogneisses against their meta-sedimentary host rock indicate that these magmas intruded as a sill complex. The SSC preserves a rather unusual flat-lying subsolidus foliation (dip &lt;40ř) associated with subhorizontal ~NE-SW-trending mineral lineation. Mesoscopic structures, anisotropy of magnetic susceptibility (AMS), and deformational microstructures indicate prolate shape of the strain ellipsoid with dominant coaxial pure shear regime. The solid state microstructures record cooling of the orthogneiss protolith down to the ambient greenschist facies conditions followed by its static recrystallization due to the intrusion of the younger...Ústav geologie a paleontologieInstitute of Geology and PaleontologyPřírodovědecká fakultaFaculty of Scienc

Devonian magmatic activity along the Teplá-Barrandian/ Moldanubian boundary

Institute of Geology and PaleontologyÚstav geologie a paleontologieFaculty of SciencePřírodovědecká fakult

Polykinematic foreland basins initiated during orthogonal convergence and terminated by orogen-oblique strike-slip faulting: An example from the northeastern Variscan belt

An extensive early Carboniferous foreland basin (the Moravosilesian Culm Basin, MSCB) delineates the northeastern margin of the Bohemian Massif (Variscan orogenic belt). The basin overlays a complex suture between the outer Brunovistulia microplate, forming a promontory previously accreted to Laurussia, and inner Gondwana-derived units that form the remainder of the Bohemian Massif. Our structural, paleomagnetic and magnetic anisotropy data from the eastern portion of the MSCB indicate that its depositional architecture, internal fabric, and deformation by folding and faulting record a major switch from orthogonal convergence to orogen-oblique strike-slip shearing. First, the Brunovistulia microcontinent was subducted frontally towards W during ~346–335 Ma, followed by a shift of the subduction vector towards ~SSW at around 335–330 Ma. From ~330 Ma onwards, the underthrusting had ceased and the ~WNW–ESE dextral Elbe shear zone, related to the westward movement of Gondwana with respect to Laurussia, controlled deformation of this region. Displacement of the northerly Eastern Sudetes ‘block’ towards ~ESE produced regional ~WNW–ESE pure-shear shortening against the Brunovistulia indentor and resulted in an overall doubly-vergent structure of the MSCB. Simultaneously, the southerly Moldanubian unit was translated towards ~WNW, away from the Brunovistulian microplate, and likely contributed to an extensional regime related to orogenic collapse progressing outward from the internal domains of the Bohemian Massif. On a larger scale, we suggest that the MSCB is an illustrative example of a polykinematic foreland basin, where deposition, syn- to post-sedimentary deformation, and thus geodynamic processes changed significantly during basin evolution, starting off with microplate impingement into a continental margin reentrant and terminated by strike-slip shearing. Our data also do not support previous models for the tectonic development of the northeastern termination of the Variscan Belt, which suggested either a large-magnitude, vertical-axis oroclinal rotation of the foreland or its translation along an orogen-perpendicular strike-slip fault