Distinct relationships of self-reported subjective memory decline to neurodegeneration across the Alzheimer's clinical continuum: Neuroimaging/Optimal neuroimaging measures for tracking disease progression

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IC-P-082: ASSOCIATION OF PERCEIVED MEMORY DECLINE WITH MULTIMODAL NEUROIMAGING AT DIFFERENT STAGES OF ALZHEIMER'S DISEASE

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P3-381: IMPACT OF THE RECRUITMENT SETTING ON THE CHARACTERISTICS OF PATIENTS WITH SUBJECTIVE COGNITIVE DECLINE

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Cross-sectional and longitudinal characterization of SCD patients recruited from the community versus from a memory clinic: subjective cognitive decline, psychoaffective factors, cognitive performances, and atrophy progression over time

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Exposure to negative socio-emotional events induces sustained alteration of resting-state brain networks in older adults

Basic emotional functions seem well preserved in older adults. However, their reactivity to and recovery from socially negative events remain poorly characterized. To address this, we designed a ‘task–rest’ paradigm in which 182 participants from two independent experiments underwent functional magnetic resonance imaging while exposed to socio-emotional videos. Experiment 1 (N = 55) validated the task in young and older participants and unveiled age-dependent effects on brain activity and connectivity that predominated in resting periods after (rather than during) negative social scenes. Crucially, emotional elicitation potentiated subsequent resting-state connectivity between default mode network and amygdala exclusively in older adults. Experiment 2 replicated these results in a large older adult cohort (N = 127) and additionally showed that emotion-driven changes in posterior default mode network–amygdala connectivity were associated with anxiety, rumination and negative thoughts. These findings uncover the neural dynamics of empathy-related functions in older adults and help understand its relationship to poor social stress recovery

O4-09-03: INTERPLAY BETWEEN BASELINE AND LONGITUDINAL CHANGE IN NEUROIMAGING MARKERS OF AMYLOID DEPOSITION AND NEURODEGENERATION ACROSS THE ALZHEIMER'S DISEASE SPECTRUM

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Impact de la durée de sommeil lent profond sur la charge amyloïde, la structure et la perfusion cérébrale au cours du vieillissement

info:eu-repo/semantics/publishe

IC-P-125: IMPACT OF THE RECRUITMENT SETTING ON THE CHARACTERISTICS OF PATIENTS WITH SUBJECTIVE COGNITIVE DECLINE

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P4-295: ASSOCIATION OF PERCEIVED MEMORY DECLINE WITH MULTIMODAL NEUROIMAGING AT DIFFERENT STAGES OF ALZHEIMER'S DISEASE

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Quali-quantitative assessment of self-reported cognitive difficulties in non-demented elders: association with medical help seeking, cognitive deficits and beta-amyloid imaging

International audienceINTRODUCTION:Subjective cognitive decline (SCD) could help identify early stages of Alzheimer's disease. However, SCD is multidetermined and protean, and the type of cognitive complaint associated with preclinical Alzheimer's disease needs refinement.METHODS:A total of 185 nondemented elders recruited from either the community or from a memory clinic filled a questionnaire. We searched for item responses associated with medical help seeking, cognitive deficits, and β-amyloidosis.RESULTS:Compared with community-recruited control subjects (n = 74), help-seeking patients reported a stronger multidomain SCD that was mostly unrelated to the presence of detectable cognitive deficits. Only a few items, notably assessing temporal disorientation, distinguished help-seeking patients with (n = 78) or without (n = 33) memory deficits. Associations between SCD and β-amyloidosis were not restricted to the memory domain and varied across clinical stages.DISCUSSION:Detailed evaluation of SCD could provide accessible indication of the presence of β-amyloid or cognitive deficits, which might prove useful for early diagnosis and clinical trial enrichment strategies