Lessons for COVID-19 vaccination from eight federal government direct communication evaluations

We discuss eight randomized evaluations intended to increase vaccination uptake conducted by the US General Services Administration’s Office of Evaluation Sciences (OES). These evaluations had a median sample size of 55,000, deployed a variety of behaviorally-informed direct communications, and used administrative data to measure vaccination uptake. The confidence interval from an internal meta-analysis shows changes in vaccination rates ranging from -0.004 to 0.394 percentage points. Two studies yielded statistically significant increases, of 0.59 and 0.16 percentage points. The other six were not statistically significant, although the studies were powered to detect effect sizes in line with published research. This work highlights the likely effects of government communications and demonstrates the value of conducting rapid evaluations to support COVID-19 vaccination efforts

Regulation of cellular sterol homeostasis by the oxygen responsive noncoding RNA lincNORS

We hereby provide the initial portrait of lincNORS, a spliced lincRNA generated by the MIR193BHG locus, entirely distinct from the previously described miR-193b-365a tandem. While inducible by low O2 in a variety of cells and associated with hypoxia in vivo, our studies show that lincNORS is subject to multiple regulatory inputs, including estrogen signals. Biochemically, this lincRNA fine-tunes cellular sterol/steroid biosynthesis by repressing the expression of multiple pathway components. Mechanistically, the function of lincNORS requires the presence of RALY, an RNA-binding protein recently found to be implicated in cholesterol homeostasis. We also noticed the proximity between this locus and naturally occurring genetic variations highly significant for sterol/steroid-related phenotypes, in particular the age of sexual maturation. An integrative analysis of these variants provided a more formal link between these phenotypes and lincNORS, further strengthening the case for its biological relevance

Missed shots at the free-throw line

Choking under pressure represents a phenomenon in which individuals faced with a high-pressure situation do not perform as well as would be expected were they performing under normal conditions. In this article, I identify determinants that predict a basketball player’s susceptibility to choking under pressure. Identification of these determinants adds to our understanding of players’ psychology at pivotal points in the game. My analysis draws on play-by-play data from ESPN.com that feature over 2 million free-throw attempts in women’s and men’s college and professional basketball games from the 2002-2013 seasons. Using regression analysis, I explore the impact of both gender and level of professionalism on performance in high-pressure situations. I find that in the final 30 seconds of a tight game, Women’s National Basketball Association and National Basketball Association players are 5.81 and 3.11 percentage points, respectively, less likely to make a free throw, while female and male college players are 2.25 and 2.09 percentage points, respectively, less likely to make a free throw, though statistical significance cannot be established among National Collegiate Athletic Association women. The discrepancy in choking between college and professional players is pronounced when comparing male college players who do and do not make it to the professional level; the free-throw performance of those destined to go pro falls 6 percentage points more in high-pressure situations. Finally, I find that women and men do not differ significantly in their propensity to choke

The Placebo Effect in Classroom Interventions

Research has shown that beliefs about the efficacy of a treatment have important effects on the treatment's success in the medical space. Does this "placebo effect" translate to the social sciences as well, in particular in the context of student effort? I address this question experimentally by exploring the causal relationship between students' beliefs about the efficacy of an intervention to improve academic performance (for instance, a testing aid) and their actual performance. The finding that student beliefs alone affect intervention outcomes would not only help researches and practitioners to understand when or whether a classroom intervention will work, but also points to promoting optimistic beliefs as a tool to increase the efficacy of these interventions

Understanding and increasing policymakers' sensitivity to program impact

Policymakers routinely make high-stakes funding decisions. Assessing the value of a program is difficult and may be affected by bounded rationality. We conducted experiments involving U.S. policymakers and the general public, in which participants were given the opportunity to assess the value of various policy programs. Our findings demonstrate that decision aids enhance the responsiveness of respondents to the impact of the programs. We designed and tested two portable decision aids—one that compares programs side-by-side and another that aggregates multiple features of impact into a single metric. The two decision aids increase the elasticity of assessments of program value with respect to impact by 0.20 on a base of 0.33 among policymakers and by 0.21 on a base of 0.21 among the general public. We provide evidence that the cognitive difficulty of translating impact-relevant information into policy decisions helps explain our finding

Informing sleep policy through field experiments

Recent progress in sleep science has greatly improved our understanding of the neurobiology of sleep and its importance for physical and mental functioning. Lab experiments have shown that insufficient sleep causes declines in cognitive and physiological function, and community studies have documented widespread sleep deprivation. Adults in the US sleep just 6.1 hours per night when objectively measured (1), well below the 7 to 9 hours recommended by experts (2). Evidence is emerging that sleep duration and quality are even lower in developing countries and among the poor in rich countries (3–5). This has led to predictions that increased sleep would have profound benefits for society, including increased productivity, academic performance, health, and safety (6). Why do people not sleep more, given these predicted benefits

The economic consequences of increasing sleep among the urban poor

The urban poor in developing countries face challenging living environments, which may interfere with good sleep. Using actigraphy to measure sleep objectively, we find that low-income adults in Chennai, India, sleep only 5.5 hours a night on average despite spending 8 hours in bed. Their sleep is highly interrupted, with sleep efficiency—sleep per time in bed—comparable to those with disorders such as sleep apnea or insomnia. A randomized three-week treatment providing information, encouragement, and improvements to home sleep environments increased sleep duration by 27 minutes a night by inducing more time in bed. Contrary to expert predictions and a large body of sleep research, increased nighttime sleep had no detectable effects on cognition, productivity, decision making, or well being, and led to small decreases in labor supply. In contrast, short afternoon naps at the workplace improved an overall index of outcomes by 0.12 standard deviations, with significant increases in productivity, psychological well-being, and cognition, but a decrease in work time

Lessons for COVID-19 vaccination from eight federal government communication evaluations

We discuss eight randomized evaluations intended to increase vaccination uptake conducted by the US General Services Administration’s Office of Evaluation Sciences (OES). These evaluations had a median sample size of 55,000, deployed a variety of behaviorally-informed direct communications, and used administrative data to measure vaccination uptake. The confidence interval from an internal meta-analysis shows changes in vaccination rates ranging from -0.004 to 0.394 percentage points. Two studies yielded statistically significant increases, of 0.59 and 0.16 percentage points. The other six were not statistically significant, although the studies were powered to detect effect sizes in line with published research. This work highlights the likely effects of government communications and demonstrates the value of conducting rapid evaluations to support COVID-19 vaccination efforts

sj-pdf-1-bsx-10.1177_23794607231192690 – Supplemental material for Using communication to boost vaccination: Lessons for COVID-19 from evaluations of eight large-scale programs to promote routine vaccinations

Supplemental material, sj-pdf-1-bsx-10.1177_23794607231192690 for Using communication to boost vaccination: Lessons for COVID-19 from evaluations of eight large-scale programs to promote routine vaccinations by Heather Barry Kappes, Mattie Toma, Rekha Balu, Russ Burnett, Nuole Chen, Rebecca Johnson, Jessica Leight, Saad B. Omer, Elana Safran, Mary Steffel, Kris-Stella Trump, David Yokum and Pompa Debroy in Behavioral Science & Policy</p