Captive Housing during Water Vole (Arvicola terrestris) Reintroduction: Does Short-Term Social Stress Impact on Animal Welfare?

Background: Animals captive bred for reintroduction are often housed under conditions which are not representative of their preferred social structure for at least part of the reintroduction process. Specifically, this is most likely to occur during the final stages of the release programme, whilst being housed during transportation to the release site. The degree of social stress experienced by individuals during this time may negatively impact upon their immunocompetence. Methodology/Principal Findings: We examined two measure of stress - body weight and Leukocyte Coping Capacity (LCC) - to investigate the effects of group size upon captive-bred water voles destined for release within a reintroduction program. Water voles were housed in laboratory cages containing between one and eight individuals. LCC scores were negatively correlated with group size, suggesting that individuals in larger groups experienced a larger degree of immunosuppression than did individuals housed in smaller groups or individually. During the course of the study mean body weights increased, in contrast to expectations from a previous study. This was attributed to the individuals sampled being sub-adults and thus growing in length and weight during the course of the investigation. Conclusions/Significance: The reintroduction process will inevitably cause some stress to the release cohort. However, for water voles we conclude that the stress experienced may be reduced by decreasing group size within captive colony and/or transportation housing practises. The findings are of significance to other species' reintroductions, in highlighting the need to consider life-history strategies when choosing housing systems for animals being maintained in captivity prior to release to the wild. A reduction in stress experienced at the pre-release stage may improve immunocompetence and thus animal welfare and initial survival post-release

Tourists’ Virtual Reality Adoption: An Exploratory Study from Lake District National Park

Virtual reality (VR) transforms the way destinations market their tourism offerings. To fully understand the opportunities of a technology, initial research is required assessing user adoption. However, empirical research and particularly exploratory qualitative research on VR adoption in tourism context is limited. Therefore, this study uses an exploratory interview approach with 35 participants near Lake District National Park, UK. Using thematic analysis, this study explores factors that influence VR adoption as well as the influencing factors on tourists’ behavioural intentions. This study adds to academia by qualitatively exploring the adoption of a scarcely researched technology within the tourism context

Effect of angiotensin-converting enzyme inhibitor and angiotensin receptor blocker initiation on organ support-free days in patients hospitalized with COVID-19

IMPORTANCE Overactivation of the renin-angiotensin system (RAS) may contribute to poor clinical outcomes in patients with COVID-19. Objective To determine whether angiotensin-converting enzyme (ACE) inhibitor or angiotensin receptor blocker (ARB) initiation improves outcomes in patients hospitalized for COVID-19. DESIGN, SETTING, AND PARTICIPANTS In an ongoing, adaptive platform randomized clinical trial, 721 critically ill and 58 non–critically ill hospitalized adults were randomized to receive an RAS inhibitor or control between March 16, 2021, and February 25, 2022, at 69 sites in 7 countries (final follow-up on June 1, 2022). INTERVENTIONS Patients were randomized to receive open-label initiation of an ACE inhibitor (n = 257), ARB (n = 248), ARB in combination with DMX-200 (a chemokine receptor-2 inhibitor; n = 10), or no RAS inhibitor (control; n = 264) for up to 10 days. MAIN OUTCOMES AND MEASURES The primary outcome was organ support–free days, a composite of hospital survival and days alive without cardiovascular or respiratory organ support through 21 days. The primary analysis was a bayesian cumulative logistic model. Odds ratios (ORs) greater than 1 represent improved outcomes. RESULTS On February 25, 2022, enrollment was discontinued due to safety concerns. Among 679 critically ill patients with available primary outcome data, the median age was 56 years and 239 participants (35.2%) were women. Median (IQR) organ support–free days among critically ill patients was 10 (–1 to 16) in the ACE inhibitor group (n = 231), 8 (–1 to 17) in the ARB group (n = 217), and 12 (0 to 17) in the control group (n = 231) (median adjusted odds ratios of 0.77 [95% bayesian credible interval, 0.58-1.06] for improvement for ACE inhibitor and 0.76 [95% credible interval, 0.56-1.05] for ARB compared with control). The posterior probabilities that ACE inhibitors and ARBs worsened organ support–free days compared with control were 94.9% and 95.4%, respectively. Hospital survival occurred in 166 of 231 critically ill participants (71.9%) in the ACE inhibitor group, 152 of 217 (70.0%) in the ARB group, and 182 of 231 (78.8%) in the control group (posterior probabilities that ACE inhibitor and ARB worsened hospital survival compared with control were 95.3% and 98.1%, respectively). CONCLUSIONS AND RELEVANCE In this trial, among critically ill adults with COVID-19, initiation of an ACE inhibitor or ARB did not improve, and likely worsened, clinical outcomes. TRIAL REGISTRATION ClinicalTrials.gov Identifier: NCT0273570

Demography and social structure of water vole populations : implications for restoration

EThOS - Electronic Theses Online ServiceGBUnited Kingdo

Intent to Speed: Cyclical Production, Topicality and the 1950s Hot Rod Movie

This essay tracks the emergence, consolidation and dissolution of the short cycle of hot rod movies that was exhibited from 1956 to 1958. The aim is to explore this cycle’s connection to topical issues and show how filmmakers used timely subjects. The essay examines the media frenzy that whirled around the subculture of hot rodding and the sensationalist marketing strategies used to promote the films, which are linked to exhibition in drive-in theatres. There is an extraordinary mismatch between the thrills promised by the sales pitch for the films and the pedestrian action of the films themselves. While showing intent to speed, few examples of the cycle actually delivered on the promise to thrill. Finally, questions of turnover and the speed of production are considered. What draws these areas of interest together is a series of enquiries about what made hot rods and hot rod culture useful to film producers and audiences

The sampling design of the study.

<p>The table presents the number of cages (37 in total) of each type, defined by cage size and number of occupants that were sampled. Only data from the first individual sampled from each cage were analysed, so the number of cages also represents the number of individuals sampled within each level of “Number in cage”.</p

Two-way between groups ANOVA.

$<p>More stringent value of <i>p</i> = 0.01 applied to account for lack of homogeneity of variances assumed by the test, indicated by a Levene’s value <0.05.</p>*<p> =  significant at the 0.05 level; ** =  significant at the 0.01 level; *** =  significant at the 0.001 level.</p><p>All Adult animals from capture session two onwards (when both captive-bred and wild-born are present; excluding pregnant or lactating females), sex, origin, site quality and session. Only two-way interactions and main effects are considered.</p

Paired-t-tests for each stress measurement at different time periods; pre-release (0), first recapture (1) and last recapture (4 OR 5). Captive-bred animals only.

*<p> = significant at the 0.05 level; ** = significant at the 0.01 level; *** = significant at the 0.001 level.</p

Number of animals sampled pre-release and in each subsequent post-release session.

<p>Number of animals sampled pre-release and in each subsequent post-release session.</p

Evaluating the role of invasive aquatic species as drivers of fine sediment-related river management problems: The case of the signal crayfish (Pacifastacus leniusculus)

Sediment quantity and quality are key considerations in the sustainable management of fluvial systems. Increasing attention is being paid to the role of aquatic biota as geomorphic agents, capable of altering the composition, mobilization and transport of fluvial sediments at various spatiotemporal scales. In this paper invasive species are presented as a special case since: (1) populations may not be constrained by factors characteristic of their native habitats; and (2) they represent a disturbance to which the system may not be resilient. Discussion is centred on the signal crayfish which has rapidly colonized catchments in Europe and Japan, but the hypotheses and models presented provide a framework applicable to other invasive species. This paper explores the mechanisms by which signal crayfish may influence sediment dynamics from the patch scale to the catchment scale. There is potential for signal crayfish to impact significantly on river sediments and morphology as a function of their interactions with river bed and bank material, and with other aquatic organisms, combined with their large body size and aggressive nature, their presence in very high densities, and the lack of effective mitigation strategies. Potential catchment-scale management issues arising from these factors include habitat degradation, mobilization of sediment-associated nutrients and contaminants, and sediment-related flood risks. Further interdisciplinary research is required at the interface between freshwater ecology, fluvial geomorphology and hydraulics, in order to quantify the significance and extent of these impacts. The paper points to the key research agendas that may now emerge. </jats:p