7,301 research outputs found
Employing pre-stress to generate finite cloaks for antiplane elastic waves
It is shown that nonlinear elastic pre-stress of neo-Hookean hyperelastic
materials can be used as a mechanism to generate finite cloaks and thus render
objects near-invisible to incoming antiplane elastic waves. This approach
appears to negate the requirement for special cloaking metamaterials with
inhomogeneous and anisotropic material properties in this case. These
properties are induced naturally by virtue of the pre-stress. This appears to
provide a mechanism for broadband cloaking since dispersive effects due to
metamaterial microstructure will not arise.Comment: 4 pages, 2 figure
A study and experiment plan for digital mobile communication via satellite
The viability of mobile communications is examined within the context of a frequency division multiple access, single channel per carrier satellite system emphasizing digital techniques to serve a large population of users. The intent is to provide the mobile users with a grade of service consistant with the requirements for remote, rural (perhaps emergency) voice communications, but which approaches toll quality speech. A traffic model is derived on which to base the determination of the required maximum number of satellite channels to provide the anticipated level of service. Various voice digitalization and digital modulation schemes are reviewed along with a general link analysis of the mobile system. Demand assignment multiple access considerations and analysis tradeoffs are presented. Finally, a completed configuration is described
Modulation of TMEM16A channel activity by the von Willebrand factor type A (VWA) domain of the calcium-activated chloride channel regulator 1 (CLCA1)
Climate model and proxy data constraints on ocean warming across the Paleocene-Eocene Thermal Maximum
Constraining the greenhouse gas forcing, climatic warming and estimates of climate sensitivity across ancient large transient warming events is a major challenge to the palaeoclimate research community. Here we provide a new compilation and synthesis of the available marine proxy temperature data across the largest of these hyperthermals, the Paleocene-Eocene Thermal Maximum (PETM). This includes the application of consistent temperature calibrations to all data, including the most recent set of calibrations for archaeal lipid-derived palaeothermometry. This compilation provides the basis for an informed discussion of the likely range of PETM warming, the biases present in the existing record and an initial assessment of the geographical pattern of PETM ocean warming. To aid interpretation of the geographic variability of the proxy-derived estimates of PETM warming, we present a comparison of this data with the patterns of warming produced by high pCO2 simulations of Eocene climates using the Hadley Centre atmosphere-ocean general circulation model (AOGCM) HadCM3L. On the basis of this comparison and taking into account the patterns of intermediate-water warming we estimate that the global mean surface temperature anomaly for the PETM is within the range of 4 to 5Ā°C
The Phase Structure of Mass-Deformed SU(2)xSU(2) Quiver Theory
The phase structure of the finite SU(2)xSU(2) theory with N=2 supersymmetry,
broken to N=1 by mass terms for the adjoint-valued chiral multiplets, is
determined exactly by compactifying the theory on a circle of finite radius.
The exact low-energy superpotential is constructed by identifying it as a
linear combination of the Hamiltonians of a certain symplectic reduction of the
spin generalized elliptic Calogero-Moser integrable system. It is shown that
the theory has four confining, two Higgs and two massless Coulomb vacua which
agrees with a simple analysis of the tree-level superpotential of the
four-dimensional theory. In each vacuum, we calculate all the condensates of
the adjoint-valued scalars.Comment: 12 pages, JHEP.cl
Structural and biophysical analysis of the CLCA1 VWA domain suggests mode of TMEM16A engagement
The secreted protein calcium-activated chloride channel regulator 1 (CLCA1) utilizes a von Willebrand factor type A (VWA) domain to bind to and potentiate the calcium-activated chloride channel TMEM16A. To gain insight into this unique potentiation mechanism, we determined the 2.0-Ć
crystal structure of human CLCA1 VWA bound to C
C-Jun N-terminal kinase 2 promotes liver injury via the mitochondrial permeability transition after hemorrhage and resuscitation
Hemorrhagic shock leads to hepatic hypoperfusion and activation of mitogen-activated stress kinases (MAPK) like c-Jun N-terminal kinase (JNK) 1 and 2. Our aim was to determine whether mitochondrial dysfunction leading to hepatic necrosis and apoptosis after hemorrhage/resuscitation (H/R) was dependent on JNK2. Under pentobarbital anesthesia, wildtype (WT) and JNK2 deficient (KO) mice were hemorrhaged to 30āmmāHg for 3āh and then resuscitated with shed blood plus half the volume of lactated Ringer's solution. Serum alanine aminotransferase (ALT), necrosis, apoptosis and oxidative stress were assessed 6āh after resuscitation. Mitochondrial polarization was assessed by intravital microscopy. After H/R, ALT in WT-mice increased from 130āU/L to 4800āU/L. In KO-mice, ALT after H/R was blunted to 1800āU/l (P < 0.05). Necrosis, caspase-3 activity and ROS were all substantially decreased in KO compared to WT mice after H/R. After sham operation, intravital microscopy revealed punctate mitochondrial staining by rhodamine 123 (Rh123), indicating normal mitochondrial polarization. At 4āh after H/R, Rh123 staining became dim and diffuse in 58% of hepatocytes, indicating depolarization and onset of the mitochondrial permeability transition (MPT). By contrast, KO mice displayed less depolarization after H/R (23%, P < 0.05). In conclusion, JNK2 contributes to MPT-mediated liver injury after H/R
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