Desarrollo de un videojuego y su tablero de baile, para el aprendizaje de matemáticas básicas

The use of apps in portable electronic devices has increased as important tool for mathematics teaching children.  Although, at the same time, children’s physical inactivity has increased. This contradiction is reversed through a basic mathematics videogame and its dancing board. To use it, the user has to do physical activity. This opportunity was identified by TRIZ Theory.  The videogame was programmed in Unity 3D™ software (free version). The device was made with free access technology and low costs materials. Before to define the best design, it was tested three different patterns. The videogame contains different difficulty levels according the user knowledge. It also has tools to identify every user performance and help to manage different class groups.El uso aplicaciones de dispositivos móviles como alternativa para el aprendizaje de matemáticas se ha incrementado en los niños; aunque su uso ha influido en el incremento del sedentarismo infantil. Se atiende la contradicción: uso de la tecnología sin sedentarismo a través de un videojuego y su tablero de baile. Su uso requiere que el usuario realice actividad física, evitando así, el sedentarismo. Se identificó la oportunidad de desarrollo por medio de la TRIZ. El videojuego se programó en el software Unity 3D™. El dispositivo se ha creado con tecnologías de libre acceso y materiales de bajo costo. Antes de seleccionar la última configuración, se probaron tres diseños diferentes. El videojuego está diseñado con niveles de dificultad acordes a los conocimientos del usuario. También posee herramientas que permiten conocer el desempeño de cada estudiante y la gestión de diferentes grupos

Nuevos registros y extensiones de distribución de reptiles (reptilía: squamata) para el estado de Zacatecas, México

Two new records of reptiles for Zacatecas are given, Sceloporus parvus and Lampropeltis alterna, also a distribution extension for Salvadora grahamiae lineata. These records confirm the presence of S. parvus and S. grahamiae lineata in the Mexican high  plateau, whereas for L. alterna the known distribution extends to the southern limit for the known distribution limit. This records increase to 67 the number of species recorded in the state. Se proporcionan dos nuevos registros de reptiles para Zacatecas; Sceloporus parvus y Lampropeltis alterna así como una extensión de distribución correspondiente a Salvadora grahamiae lineata. Estos registros confirman plenamente la presencia de S. parvus y S. grahamiae lineata en el interior del Altiplano Mexicano, en tanto  que para L. alterna se extiende notoriamente el límite sur de la distribución conocida para la especie. Estos  registros incrementan a 67 las especies de reptiles reportados para la entidad

Implementación de operaciones con servidor OPC a Excel

El fundamento principal de este proyecto es realizar el control en tiempo real del modelo de un proceso a través de un sistema de control. El control sobre un modelo puede ser útil para probar sistemas de control en sus Etapas de desarrollo, así como probar comportamientos y situaciones del proceso. Lo deseable será obtener un sistema que nos ayude a realizar una comunicación entre esclavo y servidor Para ello aprovechamos el interfaz como cliente OPC presente en la mayoría de los SCADAS actuales. OPC ofrece un interfaz desarrollado sobre las librerías COM para la comunicación de procesos, basado en el modelo cliente/servidor. El problema por tanto supone la implementación de un Servidor OPC. La implementación del proyecto supone el desarrollo de una serie de interfaces para llevar información entre Excel y Servidor OPC

ERK1/2 and p38 MAPKs Are Complementarily Involved in Estradiol 17ß-d-Glucuronide-Induced Cholestasis: Crosstalk with cPKC and PI3K

Objective: The endogenous, cholestatic metabolite estradiol 17ß-d-glucuronide (E217G) induces endocytic internalization of the canalicular transporters relevant to bile formation, Bsep and Mrp2. We evaluated here whether MAPKs are involved in this effect. Design: ERK1/2, JNK1/2, and p38 MAPK activation was assessed by the increase in their phosphorylation status. Hepatocanalicular function was evaluated in isolated rat hepatocyte couplets (IRHCs) by quantifying the apical secretion of fluorescent Bsep and Mrp2 substrates, and in isolated, perfused rat livers (IPRLs), using taurocholate and 2,4-dinitrophenyl-S-glutathione, respectively. Protein kinase participation in E217G-induced secretory failure was assessed by co-administering selective inhibitors. Internalization of Bsep/Mrp2 was assessed by confocal microscopy and image analysis. Results: E217G activated all kinds of MAPKs. The PI3K inhibitor wortmannin prevented ERK1/2 activation, whereas the cPKC inhibitor Gö6976 prevented p38 activation, suggesting that ERK1/2 and p38 are downstream of PI3K and cPKC, respectively. The p38 inhibitor SB203580 and the ERK1/2 inhibitor PD98059, but not the JNK1/2 inhibitor SP600125, partially prevented E217G-induced changes in transporter activity and localization in IRHCs. p38 and ERK1/2 co-inhibition resulted in additive protection, suggesting complementary involvement of these MAPKs. In IPRLs, E217G induced endocytosis of canalicular transporters and a rapid and sustained decrease in bile flow and biliary excretion of Bsep/Mrp2 substrates. p38 inhibition prevented this initial decay, and the internalization of Bsep/Mrp2. Contrarily, ERK1/2 inhibition accelerated the recovery of biliary secretion and the canalicular reinsertion of Bsep/Mrp2. Conclusions: cPKC/p38 MAPK and PI3K/ERK1/2 signalling pathways participate complementarily in E217G-induced cholestasis, through internalization and sustained intracellular retention of canalicular transporters, respectively.Fil: Boaglio, Andrea Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Rosario. Instituto de Fisiología Experimental (i); Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; ArgentinaFil: Zucchetti, Andrés Ernesto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Rosario. Instituto de Fisiología Experimental (i); Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; ArgentinaFil: Toledo, Flavia Daniela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Rosario. Instituto de Fisiología Experimental (i); Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; ArgentinaFil: Barosso, Ismael Ricardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Rosario. Instituto de Fisiología Experimental (i); Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; ArgentinaFil: Sanchez Pozzi, Enrique Juan. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Rosario. Instituto de Fisiología Experimental (i); Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; ArgentinaFil: Crocenzi, Fernando Ariel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Rosario. Instituto de Fisiología Experimental (i); Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; ArgentinaFil: Roma, Marcelo Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Rosario. Instituto de Fisiología Experimental (i); Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; Argentin

REAR SUSPENSION DAMPER SUPPORT VIRTUAL DURABILITY AND LOAD RECONSTRUCTION

Reliability is essential at commercial vehicles development: crucial for brand reputation and to avoid financial losses due to inoperative machinery. Vehicle suspension purpose is absorbing track roughness and ensure a comfortable and safe ride. The damper is an essential component of this system and its support must withstand typical loads, especially impacts, since the efforts are proportional to event velocity. The aim of this work is predict rear damper support life at one durability missions of product’s validation plan: Rough Road. The loads histories are crucial for reliable durability result and were reconstructed from strain measurements at strategic point, optimized to assure correlation between virtual and experimental results

Predicting the outcome of patients with subarachnoid hemorrhage using machine learning techniques

Background: Outcome prediction for subarachnoid hemorrhage (SAH) helps guide care and compare global management strategies. Logistic regression models for outcome prediction may be cumbersome to apply in clinical practice. Objective: To use machine learning techniques to build a model of outcome prediction that makes the knowledge discovered from the data explicit and communicable to domain experts. Material and methods: A derivation cohort (n = 441) of nonselected SAH cases was analyzed using different classification algorithms to generate decision trees and decision rules. Algorithms used were C4.5, fast decision tree learner, partial decision trees, repeated incremental pruning to produce error reduction, nearest neighbor with generalization, and ripple down rule learner. Outcome was dichotomized in favorable [Glasgow outcome scale (GOS) = I–II] and poor (GOS = III–V). An independent cohort (n = 193) was used for validation. An exploratory questionnaire was given to potential users (specialist doctors) to gather their opinion on the classifier and its usability in clinical routine. Results: The best classifier was obtained with the C4.5 algorithm. It uses only two attributes [World Federation of Neurological Surgeons (WFNS) and Fisher’s scale] and leads to a simple decision tree. The accuracy of the classifier [area under the ROC curve (AUC) = 0.84; confidence interval (CI) = 0.80–0.88] is similar to that obtained by a logistic regression model (AUC = 0.86; CI = 0.83–0.89) derived from the same data and is considered better fit for clinical use.This work was supported in part by the Spanish Ministries of Science under Grant TRA2007-67374-C02-02 and Health under Grant FIS PI 070152. The work of A. Lagares and J.F. Alen was supported by the Fundación Mutua Madrileña

Predictive power control strategy for a Grid-Connected 2L-VSI with fixed switching frequency

In the recent years, model predictive control has been consolidated as a design strategy and an attractive alternative for the control of power electronic devices. This paper proposes an active and reactive power control strategy based on predictive control approach applied to grid-connected renewable energy systems. To accomplish this, a three-phase two-level voltage source inverter based topology is used in combination with a simple and efficient fixed-frequency modulation technique. Results based on a MATLAB/Simulink simulation environment are discussed and the most relevant characteristics of the proposed fixed-frequency predictive control approach are highlighted considering the total harmonic distortion as a figure of merit.CONACYT – Consejo Nacional de Ciencia y TecnologíaPROCIENCI

Mercado de contrastación de medidores de agua potable: Situación actual y perspectivas

El estudio evalua el mercado de contrastación de medidores de agua para el 2009 y presenta las principales tendencias de dicho mercado al 2015

Consumo de benzodiazepinas en la población uruguaya: un posible problema de salud pública

Obje ti vo: co no cer el con su mo de ben zo dia ze pi nas en Uru guay en tre 2010 y 2012. Ma te rial y mé to do: se rea li zó un es tu dio de uti li za ción de me di ca men tos para eva luar el con su mo de ben zo dia ze pi nas usan do la dis pen sa ción de las far ma cias de las ins ti tu cio nes par ti ci pan tes. Se uti li zó la va ria ble do sis dia ria de fi ni da (DDD) por 1.000 ha bi tan tes/día (DHD). Se com pa ra ron las DHD anua les se gún el per fil hip nó ti co o an sio lí ti co y el sub sec tor de asis ten cia, pú bli co o pri va do. Re sul ta dos: se in clu yó el 62% de la po bla ción uru gua ya. Las DHD glo ba les de ben zo dia ze pi nas para los años 2010, 2011 y 2012 fue ron 74,97, 75,17 y 71,14 DDD/1.000 per so nas/día, res pec ti va men te (pro me dio 73,76). La ben zo dia ze pi na an sio lí ti - ca más con su mi da en el pe río do ana li za do fue al pra zo lam (pro me dio 25,09). La ben zo dia ze pi na hip nó ti ca más con su mi da fue flu ni tra ze pam (pro me dio 18,69). Inclu yen do clo na ze pam, esta fue la ben zo dia ze pi na más con su mi da (pro me dio 36,51) y los va lo res de con su mo glo bal au men tan a 106,36, 110,86 y 113,61 DDD/1.000 per so nas/día, res pec ti va men te (pro me dio 110,28). Clo na ze pam fue la que pre sen tó ma yor in cre men to (35,29%), mien tras que mi da zo lam (-46,15%) y dia ze pam (-18,83%) fue ron las que des cen die ron en ma yor me di da. El sub sec tor pú bli co con tri bu yó prin ci pal men te al con su mo glo bal y el pri va do fue el que ma yor au men to por cen tual tuvo. Con clu sión: Uru guay pre sen ta un ele va do con su mo de ben zo dia ze pi nas, si mi lar al ha lla do en otros paí ses, pu dien do cons - ti tuir un problema de salud pública. Este dato constituye el primero disponible en nuestro país y será útil para realizar futuras comparaciones. Es necesario implementar estrategias a nivel nacional que favorezcan un uso racional de benzodiazepinas

Comparative Analysis for the Presence of IgG Anti-Aquaporin-1 in Patients with NMO-Spectrum Disorders

Detection of IgG anti-Aquaporin-4 (AQP4) in serum of patients with Neuromyelitis optica syndrome disorders (NMOSD) has improved diagnosis of these processes and differentiation from Multiple sclerosis (MS). Recent findings also claim that a subgroup of patients with NMOSD, serum negative for IgG-anti-AQP4, present antibodies anti-AQP1 instead. Explore the presence of IgG-anti-AQP1 using a previously developed cell-based assay (CBA) highly sensitive to IgG-anti-AQP4. Serum of 205 patients diagnosed as NMOSD (8), multiple sclerosis (94), optic neuritis (39), idiopathic myelitis (29), other idiopathic demyelinating disorders of the central nervous system (9), other neurological diseases (18) and healthy controls (8), were used in a CBA over fixed HEK cells transfected with hAQP1-EGFP or hM23-AQP4-EGFP, treated with Triton X-100 and untreated. ELISA was also performed. Analysis of serum with our CBA indicated absence of anti-AQP1 antibodies, whereas in cells pretreated with detergent, noisy signal made reliable detection impossible. ELISA showed positive results in few serums. The low number of NMOSD serums included in our study reduces its power to conclude the specificity of AQP1 antibodies as new biomarkers of NMOSD. Our study does not sustain detection of anti-AQP1 in serum of NMOSD patients but further experiments are expected.Grants from “La Junta de Andalucía, Consejería de Innovación Ciencia y Empresa” (P08-CTS-03574) and Consejería de Salud (PI0298-2010), and from the “Instituto de Salud Carlos III” (Exp. PI12/01882) to Miriam Echevarría funded this work. We thank Genzyme Foundation in multiple sclerosis for giving to Miriam Echevarría one of their 2012 fellowships. We acknowledge support by the CSIC Open Access Publication Initiative through its Unit of Information Resources for Research (URICI