Digital fabrication in promoting student engagement and motivation in university courses

Abstract Project work represents a significant part of university studies, making them an important concern for teaching development. Many universities have used international engineering competitions such as the Eurobot robotics competition as a tool in engaging and motivating students. Based on a theory on why these competitions are successful, we propose how smaller-scale projects can use digital fabrication and joint projects to reach similar results. We present a case study of an ongoing robotics project course in the field of computer engineering, showing how a practical implementation of these ideas and how the field-specific problem of software intercommunication and interoperability can be solved using the Robotic Operating System software framework. While the course is still in progress, initial observations indicate that the course is going to be successful

A family with A20 haploinsufficiency presenting with novel clinical manifestations and challenges for treatment

Abstract Background: Tumor necrosis factor α–induced protein 3 gene (TNFAIP3, also called A20) haploinsufficiency (HA20) leads to autoinflammation and autoimmunity. We have recently shown that a p.(Lys91*) mutation in A20 disrupts nuclear factor κB signaling, impairs protein-protein interactions of A20, and leads to inflammasome activation. Methods: We now describe the clinical presentations and drug responses in a family with HA20 p.(Lys91*) mutation, consistent with our previously reported diverse immunological and functional findings. Results: We report for the first time that inflammasome-mediated autoinflammatory lung reaction caused by HA20 can be treated with interleukin 1 antagonist anakinra. We also describe severe anemia related to HA20 successfully treated with mycophenolate. In addition, HA20 p.(Lys91*) was found to associate with autoimmune thyroid disease, juvenile idiopathic arthritis, psoriasis, liver disease, and immunodeficiency presenting with specific antibody deficiency and genital papillomatosis. Conclusions: We conclude that HA20 may lead to combination of inflammation, immunodeficiency, and autoimmunity. The condition may present with variable and unpredictable symptoms with atypical treatment responses