46 research outputs found

    The Cholecystectomy As A Day Case (CAAD) Score: A Validated Score of Preoperative Predictors of Successful Day-Case Cholecystectomy Using the CholeS Data Set

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    Background Day-case surgery is associated with significant patient and cost benefits. However, only 43% of cholecystectomy patients are discharged home the same day. One hypothesis is day-case cholecystectomy rates, defined as patients discharged the same day as their operation, may be improved by better assessment of patients using standard preoperative variables. Methods Data were extracted from a prospectively collected data set of cholecystectomy patients from 166 UK and Irish hospitals (CholeS). Cholecystectomies performed as elective procedures were divided into main (75%) and validation (25%) data sets. Preoperative predictors were identified, and a risk score of failed day case was devised using multivariate logistic regression. Receiver operating curve analysis was used to validate the score in the validation data set. Results Of the 7426 elective cholecystectomies performed, 49% of these were discharged home the same day. Same-day discharge following cholecystectomy was less likely with older patients (OR 0.18, 95% CI 0.15–0.23), higher ASA scores (OR 0.19, 95% CI 0.15–0.23), complicated cholelithiasis (OR 0.38, 95% CI 0.31 to 0.48), male gender (OR 0.66, 95% CI 0.58–0.74), previous acute gallstone-related admissions (OR 0.54, 95% CI 0.48–0.60) and preoperative endoscopic intervention (OR 0.40, 95% CI 0.34–0.47). The CAAD score was developed using these variables. When applied to the validation subgroup, a CAAD score of ≤5 was associated with 80.8% successful day-case cholecystectomy compared with 19.2% associated with a CAAD score >5 (p < 0.001). Conclusions The CAAD score which utilises data readily available from clinic letters and electronic sources can predict same-day discharges following cholecystectomy

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    Potential of Human Embryonic Stem Cells in Cartilage Tissue Engineering and Regenerative Medicine

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    10.1007/s12015-010-9222-6Stem Cell Reviews and Reports73544-55

    Differentiation of human embryonic stem cells toward the chondrogenic lineage.

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    Methods in molecular biology (Clifton, N.J.)407333-34

    New perspectives in chondrogenic differentiation of stem cells for cartilage repair.

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    10.1100/tsw.2006.66TheScientificWorldJournal6361-36

    In vitro derivation of chondrogenic cells from human embryonic stem cells.

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    Methods in molecular biology (Clifton, N.J.)584317-33

    MSC exosome as a cell-free MSC therapy for cartilage regeneration: Implications for osteoarthritis treatment

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    10.1016/j.semcdb.2016.11.008Seminars in Cell and Developmental Biology6756-64SCDB

    MSC exosome works through a protein-based mechanism of action

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    10.1042/BST20180079Biochemical Society Transactions464843-853BCST
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