Влияние лозартана, эналаприла и их комбинации на функцию сердца

Department of Pharmacology and Clinical Pharmacy, Nicolae Testemitanu State Medical and Pharmaceutical University, Chisinau, Republic of MoldovaThe effects of the drugs Losartan, Enalapril and their combination on the hemodynamics and morphofunctional parameters of the heart were studied in 80 patients with chronic heart failure (CHF) of II-IV functional class and the ejection fraction of the left ventricle less then 45% which worsened the ischemic cardiopathia. It was established that after a 24-week therapy with each drug and their combination, there was a decrease in symptoms in every group, but more so in the group that took the combined therapy. Along with the symptoms, there was also a decrease in the functional class of the chronic heart insufficiency by 16.4% of those who took Losartan, by 15.5% of those who took Enalapril and by 19.9% of those who took the combined therapy. The treatment with Losartan increased the fraction of ejection of the left ventricle by 14.9%, with Enalapril by 8.9% and with both drugs by 21.4%. It was established that the combined therapy, which included Losartan and Enalapril, had a better impact on the parameters of the myocardium remodeling then these drugs taken seperatelyУ 80 пациентов с хронической сердечной недостаточностью II-IV функциональных классов и фракцией выброса левого желудочка менее 45% с осложнением ишемической болезни сердца изучали влияние препаратов лозартан, эналаприл и их сочетание на гемодинамические и морфофункциональные параметры сердца. Было установлено, что после 24-недельного курса лечения, все схемы терапии привели к улучшению симптоматической картины в каждой группе, но больше в группе, которая принимала комбинированную терапию. Произошло уменьшение функционального класса хронической сердечной недостаточности на 16,4% под влиянием Лозартана, на 15,5% – Эналаприла и 19,9% – комбинированной терапии. Лечение лозартаном увеличило долю выброса левого желудочка на 14,9%, Эналаприлом – на 8,9%, а обоими препаратами – на 21,4%. Было установлено, что комбинированная терапия, которая включала Лозартан и Эналаприл, имела более эффективное воздействие на параметры ремоделирования миокарда

Digital light processing stereolithography of hydroxyapatite scaffolds with bone-like architecture, permeability, and mechanical properties

This work deals with the additive manufacturing and characterization of hydroxyapatite scaffolds mimicking the trabecular architecture of cancellous bone. A novel approach was proposed relying on stereolithographic technology, which builds foam-like ceramic scaffolds by using three-dimensional (3D) micro-tomographic reconstructions of polymeric sponges as virtual templates for the manufacturing process. The layer-by-layer fabrication process involves the selective polymerization of a photocurable resin in which hydroxyapatite particles are homogeneously dispersed. Irradiation is performed by a dynamic mask that projects blue light onto the slurry. After sintering, highly-porous hydroxyapatite scaffolds (total porosity ~0.80, pore size 100-800 µm) replicating the 3D open-cell architecture of the polymeric template as well as spongy bone were obtained. Intrinsic permeability of scaffolds was determined by measuring laminar airflow alternating pressure wave drops and was found to be within 0.75-1.74 × 10−9m2, which is comparable to the range of human cancellous bone. Compressive tests were also carried out in order to determine the strength (~1.60 MPa), elastic modulus (~513 MPa) and Weibull modulus (m = 2.2) of the scaffolds. Overall, the fabrication strategy used to print hydroxyapatite scaffolds (tomographic imaging combined with digital mirror device [DMD]-based stereolithography) shows great promise for the development of porous bioceramics with bone-like architecture and mass transport properties

Noise Risk Assessment at Air Separation Plant PT. X Surabaya (Nitrogen, Oxygen, and Argon Plant)

Background : Noise was one of the dangerous factors at a workplace which causes various effects on workers. Purpose : The purpose of this research was to described the activity stages, identified the noise danger, and assessed the risk and its level at Air Separation Plant of PT. X. Methods : This research was a descriptive research with a cross sectional approach. The object of the research was the noise danger potential and the noise risk level assessment at Air Separation Plant of PT. X. Results : The result of this research showed that there were 12 identified noise danger points. These results consisted of 5 (42 %) noise risks with low category, 2 (16 %) with middle category, and another 5 (42 %) with high category. The highest noise intensity measurement result was found on Recycle Nitrogen Compressor (RNC) machine, which was 116,5 dBA. Conclusion : Based on this data, it can be concluded that there were 12 identified noise danger points and the highest noise intensity measurement result was found on Recycle Nitrogen Compressor (RNC) machine, which was 116,5 dBA. It is suggested for the related company to execute controls mostly in diminishing the noise sources

An Empirical Study on Collaborative Architecture Decision Making in Software Teams

Architecture decision making is considered one of the most challenging cognitive tasks in software development. The objective of this study is to explore the state of the practice of architecture decision making in software teams, including the role of the architect and the associated challenges. An exploratory case study was conducted in a large software company in Europe and fifteen software architects were interviewed as the primary method of data collection. The results reveal that the majority of software teams make architecture decisions collaboratively. Especially, the consultative decision- making style is preferred as it helps to make decisions efficiently while taking the opinions of the team members into consideration. It is observed that most of the software architects maintain a close relationship with the software teams. Several organisational, process and human related challenges and their impact on architecture decision-making are also identified

Synthesis and Characterization of Iron Derivatives Having a Pyridine-Linked Bis(anilide) Pincer Ligand

A pyridine-linked bis(aniline) pincer ligand, [2]H_2 ([2]H_2 = (2,6-NC_5H_3(2-(2,4,6-Me_3C_6H_2)-NHC6H4)2), has been synthesized in two steps. Deprotonation with Me_3SiCH_2Li followed by metalation with FeCl_2 yielded a LiCl adduct of [2]Fe. The complex is freed of LiCl with excess TlPF_6 or by crystallization from toluene/petroleum ether, giving [2]Fe(THF). [2]Fe(THF) reacts with I_2 and O_2 to generate [2]FeI and ([2]Fe)_2O, respectively. The complexes have been characterized by ^1H NMR spectroscopy, elemental analysis, X-ray crystallography, and UV−vis spectroscopy. [2]Fe(THF) has been examined using cyclic voltammetry

Эффективность озонотерапии в сочетании со стабильной стенокардией путем оценки велоэргометрических проб у пожилых больных

Discipline Occupational Diseases, Department of Internal Medicine No 6, Nicolae Testemitanu State Medical and Pharmaceutical University, Congresul III al Medicilor de Familie din Republica Moldova 17–18 mai, 2012, Chişinău, Republica MoldovaThe aim of this study was to assess the clinical efficacy and tolerance of ozone therapy with bicycle stress test in patients of older age groups with coronary artery disease and stable angina. The study included 36 patients with ischemic disease, including 20 men and 16 women, between the ages of 61-70 (mean 64.6 ± 4.8 years). It was proven that the use of ozone therapy in treatment of patients with coronary artery disease could improve the standard antianginal therapy, which manifests an increase in exercise tolerance, decreasing the frequency of anginal attacks, and, as a consequence, decreasing the number of nitroglycerin tablets taken. Была исследована клиническая эффективность комплексного лечения озоном у пациентов со стабильной стенокардией старших возрастных групп. В исследование было включено 36 больных с ишемической болезнью сердца, включая 20 мужчин и 16 женщин, в возрасте 61-70 лет (в среднем 64,6 ± 4,8 года). Было доказано, что использование озонотерапии в лечении пациентов с ишемической болезнью сердца улучшило стандартную терапию, которая проявлялась уменьшением частоты болевых приступов стенокардии и, как следствие, уменьшением приема таблеток нитроглицерина

Новые возможности лечения пациентов высокого сердечно-сосудистого риска

Catedra Boli Interne nr. 6, USMF „Nicolae Testemiţanu”The authors studied the influence of Simvalimit on the dynamics of the lipidic spectrum, POL-AOD, inflammation markers in the treatment of patients suffering from ischemic cardiopathy. The therapy decreased cardio discomfort, respiratory dysfunction and instability of arterial pressure 6,2±0,4 days’ earlier than the standard treatment. In the 12th week total cholesterol level decreased by 37.6%, LDL – by 24.5%, concentration of C-RP (p<0,001) – by 34.03%, IL-6 – by 26.04% (p<0,001). There was a statistically valid decrease of MDA and KD; the level of SOD dropped 1,6 times, catalase – 1,5 times. Including Simvalimit in the treatment program had a positive effect on the patients’ quality of life – physical effort, physical activity and general health increased by 21.5%, 28.7%, and 15.4% respectively.У 42 больных ИБС изучено влияние Симвалимита на динамику липидного спектра, ПОЛ-АОЗ, маркеров воспаления в процессе курсового лечения. На фоне проводимой терапии на 6,2±0,4 дня раньше, чем в группе контроля, уменьшались боли в сердце, одышка, нестабильность артериального давления. Через 12 недель лечения общий холестерин снизился на 37,6%, LDL – на 24,5%, содержание СРБ – на 34,03% (p<0,001), ИЛ-6 – на 26,04% (p<0,001). Наблюдалось также достоверное снижение МДА и КД; уровень СОД увеличился в 1,6 раза, каталазы - в 1,5 раза. Лечебные мероприятия с использованием Симвалимита благоприятным оброзом сказались на качестве жизни больных – физическая нагрузка, физическая активность и общее состояние здоровья увеличились на 21,5%, 28,7% и 15,4% соответственно

Клиническая эффективность лозартана, лизиноприла и их сочетание в лечении хронической сердечной недостаточности

Catedra Farmacologie şi farmacie clinică, USMF „Nicolae Testemiţanu”, Catedra Boli interne nr. 6, USMF „Nicolae Testemiţanu”, Spitalul Clinic al Ministerului Sănătăţii, Conferinţa Ştiinţifico-Practică „Medicina modernă, actualităţi şi perspective”, consacrată aniversării de 40 de ani ai Spitalului Clinic al Ministerului Sănătăţii, 27-28 mai, 2010, Chişinău, Republica MoldovaThe study included 60 patients with stable symptomatic CHF of II-IV functional class and ejection fraction (EF) of the left ventricle ≤ 45%. All patients completed a set of diagnostic procedures to determine the diagnosis and received severity of hemodynamic disorders and were divided into 3 groups. Group I included 20 patients receiving Losartan, group II (n = 20) Lisinopril, and group III (n = 20) received combined therapy Losartan + Lisinopril. Monitoring of the patients lasted 24 weeks. It was established that the combined therapy of Losartan and Lisinopril determined a quicker (3-4 days) diminishing of clinical symptoms of CHF compared to monotherapy. The effects of Losartan, Lisinopril and their combination on morpho-functional indices of the heart manifested by decreasing the size of the left heart chambers and improving the contractile function of left ventricle myocardium, the prevalence of these changes related more to the combined therapy.В исследование включено 60 больных со стабильными симптомами ХСН и фракцией выброса (ФВ) левого желудочка ≤ 45%. Все обследованные больные методом рандомизации были распределены на 3 группы. Первая группа включала 20 пациентов, получавших лозартан, II группа (n = 20) – лизиноприл и III группа (n = 20) комбинированную терапию – лизиноприл + лозартан. Мониторинг пациентов продолжался в течение 24 недель. Было установлено, что комбинированная терапия способствовала более быстрому купированию клинических симптомов ХСН по сравнению с монотерапией. Влияние лозартана, лизиноприла и их сочетание на морфофункциональные показатели сердца проявилось в уменьшении размеров левых камер сердца и улучшении сократительной функции миокарда левого желудочка

Zirconium and Titanium Propylene Polymerization Precatalysts Supported by a Fluxional C_2-Symmetric Bis(anilide)pyridine Ligand

Titanium and zirconium complexes supported by a bis(anilide)pyridine ligand (NNN = pyridine-2,6-bis(N-mesitylanilide)) have been synthesized and crystallographically characterized. C_2-symmetric bis(dimethylamide) complexes were generated from aminolysis of M(NMe_2)_4 with the neutral, diprotonated NNN ligand or by salt metathesis of the dipotassium salt of NNN with M(NMe_2)_2Cl_2. In contrast to the case for previously reported pyridine bis(phenoxide) complexes, the ligand geometry of these complexes appears to be dictated by chelate ring strain rather than metal–ligand π bonding. The crystal structures of the five-coordinate dihalide complexes (NNN)MCl_2 (M = Ti, Zr) display a C_1-symmetric geometry with a stabilizing ipso interaction between the metal and the anilido ligand. Coordination of THF to (NNN)ZrCl_2 generates a six-coordinate C_2-symmetric complex. Facile antipode interconversion of the C_2 complexes, possibly via flat C_(2v) intermediates, has been investigated by variable-temperature ^1H NMR spectroscopy for (NNN)MX_2(THF)_n (M = Ti, Zr; X = NMe_2, Cl) and (NNN)Zr(CH_2Ph)_2. These complexes were tested as propylene polymerization precatalysts, with most complexes giving low to moderate activities (10^2–10^4 g/(mol h)) for the formation of stereoirregular polypropylene