Quantitative Analysis of Endocytosis of Macrophage Growth Factor Receptor by Molecular Imaging

Endocytosis is a critical cellular process responsible for nutrient uptake, sampling the environment, and cellular signaling. Endocytosis of growth factor receptors is an important step in the regulation of receptor signaling functions. The macrophage growth factor receptor controls growth and differentiation of macrophages, however, the pathway by which the receptor is internalized is not well understood. The analysis showed that for the first time, knockout of endophilin A2 decreases the internalization of macrophage growth factor receptor in primary bone marrow macrophages. This shows that fast endophilin-mediated endocytosis plays a role in the control of the amount of growth factor receptors internalized in macrophages

Policy implementation in Indian Olympic sport:Exploring the potential for policy transfer

An important factor affecting sports development in India has been a longstanding issue with deploying policy initiatives introduced as early as 2001. Consequently, this paper explores policies implemented in India till today, highlighting two main issues; inadequate consideration of certain aspects of policy formulation and lack of effective implementation. Policy transfer is then explored as an option to overcome formulation issues of lack of feasibility, financial assistance and knowledge. The success of policy transfer (both external and internal) would, however, depend on how effectively India manages to implement the policies. India can formulate the best policies but, if they are not implemented effectively, the return might remain low. Consequently, we highlight the need for India to prioritise effective policy implementation whilst considering policy transfer as an option to overcome formulation issues