A genome-wide functional investigation into the roles of receptor-like proteins in Arabidopsis

Receptor-like proteins (RLPs) are cell surface receptors that typically consist of an extracellular leucine-rich repeat domain, a transmembrane domain, and a short cytoplasmatic tail. In several plant species, RLPs have been found to play a role in disease resistance, such as the tomato (Solanum lycopersicum) Cf and Ve proteins and the apple (Malus domestica) HcrVf2 protein that mediate resistance against the fungal pathogens Cladosporium fulvum, Verticillium spp., and Venturia inaequalis, respectively. In addition, RLPs play a role in plant development; Arabidopsis (Arabidopsis thaliana) TOO MANY MOUTHS (TMM) regulates stomatal distribution, while Arabidopsis CLAVATA2 (CLV2) and its functional maize (Zea mays) ortholog FASCINATED EAR2 regulate meristem maintenance. In total, 57 RLP genes have been identified in the Arabidopsis genome and a genome-wide collection of T-DNA insertion lines was assembled. This collection was functionally analyzed with respect to plant growth and development and sensitivity to various stress responses, including susceptibility toward pathogens. A number of novel developmental phenotypes were revealed for our CLV2 and TMM insertion mutants. In addition, one AtRLP gene was found to mediate abscisic acid sensitivity and another AtRLP gene was found to influence nonhost resistance toward Pseudomonas syringae pv phaseolicola. This genome-wide collection of Arabidopsis RLP gene T-DNA insertion mutants provides a tool for future investigations into the biological roles of RLPs

From Kongsi

The history of Chinese ethnic migration to Bangka Island is inseparable from the history of economic expansion based on production from tin mining. Initially, the Chinese were brought as coolie to work in tin mines and then had a major influence on tin management in this area to date. This paper traces the transformation of Chinese influence in tin mining so that this paper will be focused on the organization and production process. This paper is obtained from the results of qualitative research that has an explorative pattern. This study found that the transformation of Chinese influence in tin mining occurred in at least two forms, namely transformation in worker organization, and transformation in the production process. In worker organizations, it was found that Chinese involvement in workers was organized by tiko in a kongsi form, in the form of a partnership. When the reforms began and open mining began to flourish, the ethnic Chinese were transformed into tin owners and traders, no longer as coolie. Transformation also occurs in the form of the use of Sa Kan technology in the production process that is used even more varied in the post-reform period of 1998. This study observed that the technology used since the early has contributed to the damage to the environment, although the rate of damage it is manual compared to newer and more masive technologies since the last of two decades

Persisting pan-institutional racism

Which types of group-typing amounts to racism? The answer seemingly has to do with deeper physical or cultural traits over which an agent has no deliberate control but which are formative of the agent. In this article, I look to the cultural or ethnic bases of division of humans into races, albeit of a specific type: a basis that sees humanity climbing in a certain, presumably improving, direction. Those ethnicities that appear not to opt for this climb are commonly presumed – if tacitly – inferior. This outlook is so common, particularly in industrial, governmental, economic-developmental, academic and other intellectual and influential, high-profile institutional settings, it is hard to descry. This article aims to bring this racism, referred to as ‘pan-institutional’ because it extends from local to national and international institutions, into fuller light. The article argues that prominent pan-institutions, including government, academia and industry, work together to propagate this racism, even while these institutions aver they are spreading benevolence to less fortunate cultures, in the cause of cultural, economic and social globalization. In this way, these pan-institutions follow precisely in step with earlier colonialism and missionarism. The article ethically assesses this covert racist pan-institutional movement, reveals the quandaries that many indigenous cultures, especially foragers, face as this movement encroaches on them, and analyses how it is best understood as a refurbishing of colonialism in the name of benevolence. The argument ends by describing how such benevolent globalization builds upon misanthropy and it analyses the moral implications and why this most covert and widespread movement is, like more visible and standard racisms, wrong-headed, unethical, fatal, misanthropist and perhaps self-hating

Cost-effectiveness of laparoscopic ileocaecal resection versus infliximab treatment of terminal ileitis in Crohn's disease: The LIR!C Trial

Objective Evaluate the cost-effectiveness of laparoscopic ileocaecal resection compared with infliximab in patients with ileocaecal Crohn's disease failing conventional therapy. Design A multicentre randomised controlled trial was performed in 29 centres in The Netherlands and the UK. Adult patients with Crohn's disease of the terminal ileum who failed >3 months of conventional immunomodulators or steroids without signs of critical strictures were randomised to laparoscopic ileocaecal resection or infliximab. Outcome measures included quality-adjusted life-years (QALYs) based on the EuroQol (EQ) 5D-3L Questionnaire and the Inflammatory Bowel Disease Questionnaire (IBDQ). Costs were measured from a societal perspective. Analyses were performed according to the intention-to-treat principle. Missing cost and effect data were imputed using multiple imputation. Cost-effectiveness planes and cost-effectiveness acceptability curves were estimated to show uncertainty. Results In total, 143 patients were randomised. Mean Crohn's disease total direct healthcare costs per patient at 1 year were lower in the resection group compared with the infliximab group (mean difference €-8931; 95% CI €-12 087 to €-5097). Total societal costs in the resection group were lower than in the infliximab group, however not statistically significant (mean difference €-5729, 95% CI €-10 606 to €172). The probability of resection being cost-effective compared with infliximab was 0.96 at a willingness to pay (WTP) of €0 per QALY gained and per point improvement in IBDQ Score. This probability increased to 0.98 at a WTP of €20 000/QALY gained and 0.99 at a WTP of €500/point of improvement in IBDQ Score. Conclusion Laparoscopic ileocaecal resection is a cost-effective treatment option compared with infliximab. Clinical trial registration number Dutch Trial Registry NTR1150; EudraCT number 2007-005042-20 (closed on 14 October 2015)