An industrial survey on the use of surface texture parameters

In 1999, CIRP conducted an industrial survey of the use of surface texture parameters [1]. In the seventeen years since, much has changed, with the most important advancement being the introduction of areal surface texture parameters as described in ISO 25178-2 [2]. There has also been the release of commercial software packages for the calculation of surface texture parameters and, therefore, it is expected that industry is starting to embrace areal surface texture characterisation. Industry is also increasingly using more optical instruments, which are often inherently areal in nature. These factors bring to light the need for a new parameter survey, to investigate whether industry really has been adopting areal surface texture parameters. This study used an online survey to obtain information about the current use of surface texture parameters in industry. The survey features both profile and areal surface texture parameters defined in specification standards ISO 4287 [3], ISO 25178-2 [2], ISO 12085 [4] and ISO 16565-2/3 [5, 6]. The survey was open to responses for eight months and obtained a total of 179 responses from a variety of industrial users of surface texture parameters spread across thirty-two countries. Responses from the survey offer information about the usage of individual surface texture parameters, highlighting any parameters that are unpopular and may require attention. The survey also enables participants to share their opinion on the current range of parameters in use, giving an insight into the perception of surface texture parameters in industry. The results from the survey highlight a strong adoption by industry of the areal surface texture parameters defined in ISO 25178-2. In comparison to the 1999 survey, there has also been an overall increase in the use of profile surface texture parameters, and an increase in the variety of parameters used, particularly for the ISO 4287 roughness parameters, suggesting a better understanding of the range of parameters available and their uses. Conversely, this increase in parameter variety could be due to the greater computational power available to users of surface texture parameters, allowing them to use more parameters with little cost. The results of the surface texture parameter survey will serve as an indication of the current state of the industry to those interested in the widespread acceptance and evolution of surface texture parameters. The analysis of the survey will identify common potential improvement areas in surface texture parameter selection and provide a starting point from which to better promote the current selection and better educate the users

Volumes of polytopes in spaces of constant curvature

We overview the volume calculations for polyhedra in Euclidean, spherical and hyperbolic spaces. We prove the Sforza formula for the volume of an arbitrary tetrahedron in $H^3$ and $S^3$. We also present some results, which provide a solution for Seidel problem on the volume of non-Euclidean tetrahedron. Finally, we consider a convex hyperbolic quadrilateral inscribed in a circle, horocycle or one branch of equidistant curve. This is a natural hyperbolic analog of the cyclic quadrilateral in the Euclidean plane. We find a few versions of the Brahmagupta formula for the area of such quadrilateral. We also present a formula for the area of a hyperbolic trapezoid.Comment: 22 pages, 9 figures, 58 reference

Combined analysis of Two-Year Follow-up from two open-label randomized trials comparing efficacy of three nucleoside reverse transcriptase inhibitor backbones for previously untreated HIV-1 nfection: OzCombo 1 and 2

Purpose: To compare inhibition of HIV replication, improvements in CD4+ T-cell counts, metabolic parameters, and body shape changes after 2 years of assigned therapy in OzCombo patients. Method: Study participants were those who were recruited into the open-label OzCombo 1 (1996/1997) and OzCombo 2 (1997/1998) trials. Patients in OzCombo 1 were randomized to receive indinavir in combination with zidovudine+lamivudine (AZT+3TC; n = 35), stavudine (d4T)+3TC (n = 34), or d4T+didanosine (ddI) (n = 37). OzCombo 2 patients were randomized to the same nucleoside reverse transcriptase inhibitor (NRTI) backbones with nevirapine (n = 20, 22, 23, respectively). The mean time-weighted changes from baseline in CD4 T-cell count/mL, HIV RNA (log copies/mL plasma), and proportions with detectable viral load (<500 copies plasma HIV RNA/mL) between NRTI arms over 2 years were compared by formal meta-analysis. A cross-sectional study of metabolic and body shape complications was also undertaken. Results: For the comparison of d4T+3TC and d4T+ddI to AZT+3TC, mean differences in time-weighted change from baseline in CD4 T-cell count/wL and log copies HIV RNA/mL adjusted for baseline CD4+ T-cell and HIV RNA counts were: m44 (p = .08) and m14 (p = .56) cells/wL and m0.1 (p = .40) and m0.1 (p = .6) copies/mL. Odds ratios for detectable viral load in the last study quarter were 0.6 (p = .44) and 1.0 (p = .95). The mean percent leg fat was lower in the d4T+3TC and d4T+ddI than the AZT+3TC arm (mean difference 5.1% [p = .07] and 7.6% [p = .02], respectively). Conclusion: For all regimens, virological control and immunological response were maintained over 2 years. Regimens containing d4T and particularly d4T+ddI were significantly associated with increased peripheral fat loss compared with AZT+3TC

Genome-wide and fine-resolution association analysis of malaria in West Africa

We report a genome-wide association (GWA) study of severe malaria in The Gambia. The initial GWA scan included 2,500 children genotyped on the Affymetrix 500K GeneChip, and a replication study included 3,400 children. We used this to examine the performance of GWA methods in Africa. We found considerable population stratification, and also that signals of association at known malaria resistance loci were greatly attenuated owing to weak linkage disequilibrium (LD). To investigate possible solutions to the problem of low LD, we focused on the HbS locus, sequencing this region of the genome in 62 Gambian individuals and then using these data to conduct multipoint imputation in the GWA samples. This increased the signal of association, from P = 4 × 10(-7) to P = 4 × 10(-14), with the peak of the signal located precisely at the HbS causal variant. Our findings provide proof of principle that fine-resolution multipoint imputation, based on population-specific sequencing data, can substantially boost authentic GWA signals and enable fine mapping of causal variants in African populations