Towards a complete and continuous Wigner function for an ensemble of spins or qubits

We present a new quasi-probability distribution function for ensembles of spin-half particles or qubits that has many properties in common with Wigner's original function for systems of continuous variables. We show that this function provides clear and intuitive graphical representation of a wide variety of states, including Fock states, spin-coherent states, squeezed states, superpositions and statistical mixtures. Unlike previous attempts to represent ensembles of spins/qubits, this distribution is capable of simultaneously representing several angular momentum shells

New insights into the genetic etiology of Alzheimer's disease and related dementias

Characterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/'proxy' AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele

Teaching qualitative research methods through service-learning

This paper is the result of a voluntary service-learning component in a qualitative research methods course. For this course, the service-learning project was the evaluation of the benefits to volunteers whom work a crisis hotline for a local crisis intervention center. The service-learning course model used in this paper most closely resembles the problem-based service-learning course model where students work as consultants. This paper focuses on the processes involved and the benefits to students in improving their qualitative research skills through the service-learning project

Metformin enhances anti-mycobacterial responses by educating CD8+ T-cell immunometabolic circuits

10.1038/s41467-020-19095-zNature Communications111522