The Painleve Test and Reducibility to the Canonical Forms for Higher-Dimensional Soliton Equations with Variable-Coefficients

The general KdV equation (gKdV) derived by T. Chou is one of the famous (1+1) dimensional soliton equations with variable coefficients. It is well-known that the gKdV equation is integrable. In this paper a higher-dimensional gKdV equation, which is integrable in the sense of the Painleve test, is presented. A transformation that links this equation to the canonical form of the Calogero-Bogoyavlenskii-Schiff equation is found. Furthermore, the form and similar transformation for the higher-dimensional modified gKdV equation are also obtained.Comment: Published in SIGMA (Symmetry, Integrability and Geometry: Methods and Applications) at http://www.emis.de/journals/SIGMA

Does a Wife’s Employment Affect her Husband’s Retirement Decision? : Evidence from Japanese Longitudinal Data

Based on a large longitudinal dataset on Japanese middle-aged and older individuals, the purpose of this study is to investigate whether women’s labor force participation affects their husbands’ retirement decisions. Employing a simple fixed-effects model, a significant positive effect of wives’ labor force participation on husbands’ retirement decisions was found, which seems to imply that a husband’s leisure is complementary to that of his wife. However, when employing instrumental variables such as the wife’s health condition, the existence of care needs in the household, and statutory pensionable age, no significant effect of the wife’s employment on her husband’s retirement decision was found, regardless of employment type. This result indicates that a Japanese wife’s retirement decision is independent of her husband’s employment and marks a sharp contrast with those of western industrialized countries

Clinicopathologic Analysis of Localized Nasal/Paranasal Diffuse Large B-Cell Lymphoma

Diffuse large B-cell lymphoma (DLBCL) comprises 2 molecularly distinct subgroups of non-germinal center B-cell-like (non-GCB) and germinal center B-cell-like (GCB) DLBCLs, with the former showing relatively poor prognosis. In the present study, we analyzed the clinicopathological features of 39 patients with localized nasal/paranasal DLBCL. Immunohistochemistry-based subclassification revealed that 11 patients (28%) were of the GCB-type according to Hans' algorithm and 11 (28%) were of the GCB-type according to Choi's algorithm. According to both Hans' and Choi's algorithms, the non-GCB type was predominant. Nevertheless, prognosis was good. Overall survival did not differ significantly between the GCB and non-GCB subgroups (Hans' algorithm: p = 0.57, Choi's algorithm: p = 0.99). Furthermore, the prognosis of localized nasal/paranasal DLBCL was better than that of other localized extranodal DLBCLs. The prognosis of extranodal DLBCL is usually considered poorer than that of nodal DLBCL. However, in our study, no difference was noted between patients with localized nasal/paranasal DLBCL and patients with localized nodal DLBCL. In conclusion, although the non-GCB subtype is thought to show poor prognosis, in our study, the prognosis for localized nasal/paranasal DLBCL patients was good irrespective of subclassification

Dual Antiplatelet Therapy Can Be Discontinued at Three Months after Implantation of Zotarolimus-Eluting Stent in Patients with Coronary Artery Disease

Dual antiplatelet therapy (DAPT) after percutaneous coronary intervention increases the risk of bleeding. We studied the safety and clinical outcomes of switching from DAPT to aspirin monotherapy at 3 months after ZES implantation. We retrospectively evaluated 168 consecutive patients with coronary artery disease who had been implanted with a ZES from June 2009 through March 2010. After excluding 40 patients according to exclusion criteria such as myocardial infarction, 128 patients were divided into a 3-month DAPT group (67 patients, 88 lesions) and a 12-month conventional DAPT group (61 patients, 81 lesions). Coronary angiographic followup and clinical followup were conducted at more than 8 months and at 12 months after ZES implantation, respectively. Minor and major bleeding events, stent thrombosis (ST), and major adverse cardiac events (MACE) (death, myocardial infarction, cerebrovascular accident, target lesion revascularization, and target vessel revascularization) were evaluated. There were no statistically significant differences in the incidences of ST and MACE between the two groups. The incidence of bleeding events was significantly lower in the 3-month group than in the 12-month group (1.5% versus 11.5%, ). DAPT can be safely discontinued at 3 months after ZES implantation, which reduces bleeding risk

An Autopsy Case of Pleomorphic Leiomyosarcoma arising from the Uterus

A 49-year-old female patient was referred to this hospital due to uterine tumor. Needle biopsy of the uterine body was done after admission which suggested MFH (malignant fibrous histiocytoma) or poorly differentiated adenocarcinoma. The patient died after 11 days of admission before doing any surgical treatment for the tumor. Autopsy disclosed an adult head-sized pelvic tumor mass with multiple metastasis in lung, peritoneum and intestine. We confirmed the diagnosis of the present case as pleomorphic leiomyosarcoma by immunohistochemical study and electron microscopy in addition to routine light microscopy. The DNA distribution pattern of the tumor was determined by cytofluorometry and it was aneuploidy. The case report is presented with histological, immunohistochemical, electron microscopical, and cytofluorometrical study herein

A Case Report of Malignant Mullerian Mixed Tumor of the Uterus

We experienced a case of malignant Mullerian mixed tumor of the uterus of a 58-year-old female. We performed an immunohistochemical study in order to analyze the expression of various antigens in different elements of this tumor. Keratin, carcinoembryonic antigen (CEA), and epithelial membrane antigen (EMA) showed strong positive results in epithelial component, while EMA also showed positive results in some areas of sarcomatous elements. On the other hand, vimentin and S-100 gave strong positive result in non-epithelial component, but also was positive to some extent in epithelial component in this tumor. Immunohistochemical method was useful to differentiate the different components of this tumor. However, EMA, Vimentin and S-100 showed some unusual results. This discrepancy may indicate a change in the nature of tumor cells due to `microenvironmental\u27 factors such as hormones and vita - mins. Therefore, careful evaluation is necessary to interpret the immunohistochemical results in surgical pathology

Antitumor Activity of Activated Lymphocytes and Macrophages by Liposome-borne Tumor-specific Transplantation Antigens on Postsurgical Tumor Recurrence in Murine

Liposome-borne tumor-specific transplantation antigens (TSTA) potentiated the antitumor activity of cytotoxic lymphocytes and macrophages (Mφ) much more efficiently than empty liposomes in murine. Mφ obtained from peritoneum and lung as well as cytotoxic T-lymphocytes (CTL) such as lymphokine-activat-ed killer (LAIC) cells and tumor infiltrating lymphocytes (TIL) showed higher inhibitory activity on metastatic tumor cell growth in lung. Among the effector lymphocytes in vivo, TIL showed desiable antitumor activity by way of intra-venous injection, while peritoneal Mφ showed high cytotoxicity by intraper-itoneal injection and intraveneously alveolar Mφ also showed high cytotoxic activity. These results suggest that the suitable administrations of liposome-borne TSTA may be useful in potentiating the tumoricidal effect of effector cells in vivo, especially TIL, CTL, and Mφ, and possibly may aid in overcoming tumor metastases

Signal-transducing adaptor protein-2 delays recovery of B lineage lymphocytes during hematopoietic stress

Signal-transducing adaptor protein-2 (STAP-2) was discovered as a C-FMS/M-CSFR interacting protein and subsequently found to function as an adaptor of signaling or transcription factors. These include STAT5, MyD88 and IκB kinase in macrophages, mast cells, and T cells. There is additional information about roles for STAP-2 in several types of malignant diseases including chronic myeloid leukemia, however, none have been reported concerning B lineage lymphocytes. We have now exploited gene targeted and transgenic mice to address this lack of knowledge, and demonstrated that STAP-2 is not required under normal, steady-state conditions. However, recovery of B cells following transplantation was augmented in the absence of STAP-2. This appeared to be restricted to cells of B cell lineage with myeloid rebound noted as unremarkable. Furthermore, all hematological parameters were observed to be normal once recovery from transplantation was complete. Furthermore, overexpression of STAP-2, specifically in lymphoid cells, resulted in reduced numbers of late-stage B cell progenitors within the bone marrow. While numbers of mature peripheral B and T cells were unaffected, recovery from sub-lethal irradiation or transplantation was dramatically reduced. Lipopolysaccharide (LPS) normally suppresses B precursor expansion in response to interleukin 7, however, STAP-2 deficiency made these cells more resistant. Preliminary RNA-Seq analyses indicated multiple signaling pathways in B progenitors as STAP-2-dependent. These findings suggest that STAP-2 modulates formation of B lymphocytes in demand conditions. Further study of this adapter protein could reveal ways to speed recovery of humoral immunity following chemotherapy or transplantation