287 research outputs found
Onecut-dependent Nkx6.2 transcription factor expression is required for proper formation and activity of spinal locomotor circuits.
In the developing spinal cord, Onecut transcription factors control the diversification of motor neurons into distinct neuronal subsets by ensuring the maintenance of Isl1 expression during differentiation. However, other genes downstream of the Onecut proteins and involved in motor neuron diversification have remained unidentified. In the present study, we generated conditional mutant embryos carrying specific inactivation of Onecut genes in the developing motor neurons, performed RNA-sequencing to identify factors downstream of Onecut proteins in this neuron population, and employed additional transgenic mouse models to assess the role of one specific Onecut-downstream target, the transcription factor Nkx6.2. Nkx6.2 expression was up-regulated in Onecut-deficient motor neurons, but strongly downregulated in Onecut-deficient V2a interneurons, indicating an opposite regulation of Nkx6.2 by Onecut factors in distinct spinal neuron populations. Nkx6.2-null embryos, neonates and adult mice exhibited alterations of locomotor pattern and spinal locomotor network activity, likely resulting from defective survival of a subset of limb-innervating motor neurons and abnormal migration of V2a interneurons. Taken together, our results indicate that Nkx6.2 regulates the development of spinal neuronal populations and the formation of the spinal locomotor circuits downstream of the Onecut transcription factors
Staff Perceptions of Risk for Prison Rape Perpetration and Victimization
Copyright © 2012 SAGE Publications, http://tpj.sagepub.com Used by permission
Singing the same tune? International continuities and discontinuities in how police talk about using force
This article focuses on a research project conducted in six jurisdictions: England, The Netherlands, Germany, Australia, Venezuela, and Brazil. These societies are very different ethnically, socially, politically, economically, historically and have wildly different levels of crime. Their policing arrangements also differ significantly: how they are organised; how their officers are equipped and trained; what routine operating procedures they employ; whether they are armed; and much else besides. Most relevant for this research, they represent policing systems with wildly different levels of police shootings, Police in the two Latin American countries represented here have a justified reputation for the frequency with which they shoot people, whereas at the other extreme the police in England do not routinely carry firearms and rarely shoot anyone. To probe whether these differences are reflected in the way that officers talk about the use of force, police officers in these different jurisdictions were invited to discuss in focus groups a scenario in which police are thwarted in their attempt to arrest two youths (one of whom is a known local criminal) by the youths driving off with the police in pursuit, and concludes with the youths crashing their car and escaping in apparent possession of a gun, It might be expected that focus groups would prove starkly different, and indeed they were, but not in the way that might be expected. There was little difference in affirmation of normative and legal standards regarding the use of force. It was in how officers in different jurisdictions envisaged the circumstances in which the scenario took place that led Latin American officers to anticipate that they would shoot the suspects, whereas officers in the other jurisdictions had little expectation that they would open fire in the conditions as they imagined them to be
Violence today
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/45468/1/11089_2005_Article_BF01768523.pd
A Literature Survey and Classifications on Data Deanonymisation
The problem of disclosing private anonymous data has become increasingly serious particularly with the possibility of carrying out deanonymisation attacks on publishing data. The related work available in the literature is inadequate in terms of the number of techniques analysed, and is limited to certain contexts such as Online Social Networks. We survey a large number of state-of-the-art techniques of deanonymisation achieved in various methods and on different types of data. Our aim is to build a comprehensive understanding about the problem. For this survey, we propose a framework to guide a thorough analysis and classifications. We are interested in classifying deanonymisation approaches based on type and source of auxiliary information and on the structure of target datasets. Moreover, potential attacks, threats and some suggested assistive techniques are identified. This can inform the research in gaining an understanding of the deanonymisation problem and assist in the advancement of privacy protection
Criminals with ‘Community Spirit’: Practising Citizenship in the Hidden World of the Prison
Corporate Volunteering Climate: Mobilizing Employee Passion for Societal Causes and Inspiring Future Charitable Action
Organophosphazenes. 13. Reactions of hexafluorocyclotriphosphazene with p-(dimethylamino)phenyl Grignard and lithium reagents
- …