Phosphorylation of survivin at threonine 34 inhibits its mitotic function and enhances its cytoprotective activity

Survivin is an essential chromosomal passenger protein required for mitotic progression. It is also an inhibitor of apoptosis and can prevent caspase-mediated cell death. In addition, survivin levels are elevated in cancer cells where its presence correlates with increased resistance to chemo- and radio-therapy, which makes it an attractive target for novel anti-cancer strategies. Interestingly, survivin is phosphorylated by the mitotic kinase, cdk1, and a non-phosphorylatable form, survivin(T34A), cannot inhibit apoptosis. Here we rigorously test the ability of survivin(T34A) and its corresponding phosphomimetic, survivin(T34E), to promote cell viability through survivin's dual roles. The effects of these mutations are diametrically opposed: survivin(T34A) accelerates cell proliferation and promotes apoptosis, whereas survivin(T34E) retards growth and promotes survival. Thus the phosphorylation status of survivin at T34 is pivotal to a cell's decision to live or die

Utilities and residential tenancies - part 2: future directions for rental housing standards

This report considers a range of data and regulatory and policy interventions from international and domestic jurisdictions with the objective of improving the provision of utilities for private rental housing in Victoria. Overview There are a range of issues affecting the provision of utilities to tenants, particularly: low income households are more likely to occupy rental dwellings with a combination of low thermal effi ciency and ineffi cient appliances tenants are unlikely to be able to upgrade appliances or relocate to dwelling of higher thermal quality due to other market pressures energy consumption and costs are higher for many tenants relative to equivalant households in other tenures market processes and programs often preclude participation from residential tenants or have onerous access barriers Future Directions for Rental Housing Standards provides: a discussion of options for energy effi ciency improvements in the conclusion of Part one a discussion of current regulatory processes concerning the energy and water effi ciency of private rental housing options for improving the provision of energy and water services including both regulatory and non-regulatory options a focus on the policy processes arising from Council of Australian Government (COAG) reform

Descriptions of Lutzomyia (Evandromyia) georgii n. sp. and a synopsis of the Series infraspinosa (Diptera: Psychodidae)

Lutzomyia georgii n. sp. and the female of L. tarapacaensis in the Series infraspinosa of the subgenus Evandromyia are described, from specimens collected in rainforest in the north of the State of Para, Brazil. The new species was taken together with five other Evandromyia species including L. infraspinosa (sensu strictu) in the same locality, I., georgii has previously been confused with both L. begonae and L. infraspinosa, whereas L. tarapacaensis would run to L. infraspinosa in recent taxonomic keys. The fact that both L. georgii and L. tarapacaensis are locally sympatric with L. infraspinosa helps to clarify the taxonomic limits of the latter species. New keys to the subgenus Evandromyia are provided

Lutzomyia derelicta (Diptera: Psychodidae) a Singular New Phlebotomine Sand Fly from an Inselberg in Northeastern Amazonia

Lutzomyia derelicta n. sp. is described from specimens collected in an isolated xeric habitat in the rainforest in the north of the State of Pará, Brazil. The new species lacks the posterior bulge in the dorsal wall of the cibarium characteristic of the New World genus Lutzomyia, and the armature of the male genitalia is of the pattern found elsewhere only in the Old World species of Sergentomyia. L. derelicta is phenetically intermediate between the known species of Lutzomyia and Sergentomyia, and cannot readily be placed in any existing subgenus or species group of either genus

Phlebotomine Sand Flies from São Gabriel da Cachoeira (State of Amazonas, Brazil) with a Description of Lutzomyia (Psychodopygus) douradoi n. sp. (Diptera: Psychodidae)

Thirty-five species of Lutzomyia and two species of Brumptomyia were identified among 795 phlebotomines taken in light-traps near the upper reaches of the middle Rio Negro. The subgenus Psychodopygus predominated in number of species (11) and relative abundance (74-81% in light trap samples from the forest and 99% on human bait). For many of the species these records help to fill large gaps on current maps of distribution, and for others (L. olmeca nociva, L. mangabeirana, L. triacantha) the findings represent a significant expansion of their known range. A new species in the subgenus Psychodopygus (L. douradoi) is described from both sexes, and L. bettinii is recorded for the first time in Brazil

Lutzomyia maruaga (Diptera: Psychodidae), a new bat-cave sand fly from Amazonas, Brazil

A new species of parthenogenetic, autogenic and apparently extremely endemic phlebotomine is described from a sandstone cave located in primary terra firme forest to the North of the city of Manaus. Specimens were collected in the aphotic zone of the Refúgio do Maruaga cave by light trap and reared from bat guano. The adult morphology suggests a closer relationship to some Old World Phlebotominae than to species of Lutzomyia França encountered in the surrounding rainforest, but it shares characteristics with the recently proposed Neotropical genera Edentomyia Galati, Deanemyia Galati and Oligodontomyia Galati

Years of good life based on income and health: re-engineering cost-benefit analysis to examine policy impacts on wellbeing and distributive justice

In this paper, we propose a practical measure of individual wellbeing to facilitate the economic evaluation of public policies. We propose to evaluate policies in terms of years of good life gained, in a way that complements and generalises conventional cost-benefit analysis in terms of money. We aim to show how years of good life could be measured in practice by harnessing readily available data on three important elements of individual wellbeing: income, health-related quality of life, and longevity. We also aim to identify the main ethical assumptions needed to use this measure