Measurement of Individuality in the Thinking Patterns(International & Interdisciplinary Symposium on What is Evolution? Bicentennial of Charles Darwin's Birth)

この論文は国立情報学研究所の電子図書館事業により電子化されました

Rehabilitation Strategy for the Improvement of Life Space Mobility and Health-related Quality of Life in Patients with Total Knee Arthroplasty

早大学位記番号:新9218博士(スポーツ科学)早稲田大

Efeito das variáveis de processo na redução da atividade de água de mapará (Hypophthalmus edentatus) desidratado osmoticamente.

Através do método de superfície de resposta aplicado no processo de desidratação osmótica de filés de mapará, verificou-se que os termos lineares e quadráticos das três variáveis foram significativos para a resposta atividade de água. O modelo foi considerado significativo e preditivo a 95% de confiança

Housing safety net measures for those who require housing security consideration and Approaches to social work

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Comparison of Outcome of Hepatectomy with Thoraco-abdominal or Abdominal Approach

Background/Aims: Thoraco-abdominal approach is a suitable choice for hepatectomy to secure good view for mobilization. The aim of this study was to assess efficacy of thoraco-abdominal approach (TAA) for hepatectomy. Methodology: There were compared clinicopathological data, surgical results and postoperative complications of 425 consecutive patients who underwent hepatectomy via abdominal (AA) (n=147) or TAA (n=278). Results: Blood loss and operating time were significantly higher in TAA than AA group (970 vs. 830ml and 408 vs. 372 min.)(p<0.05). Prevalence of pleural effusion was significantly higher in TAA than AA group (24 vs. 9%) (p<0.01). However, proportions of patients who developed hepatic complications such as biloma (14 vs. 23%), and wound infection (8 vs.25%) were significantly less in TAA than AA group (p<0.05). Hospital stay after hepatectomy and mortality were similar between both groups. Presence of chronic viral hepatitis, lower platelet count, higher level of serum hyaluronic acid, larger blood loss and TAA correlated significantly with thoracic complications (p<0.05). Multivariate analysis showed that increased blood loss (p=0.011), but not TAA, was a significant determinant of thoracic complications (p=0.08). Conclusions: TAA can be considered a relatively safe approach for hepatectomy with minimal abdominal complications nevertheless of frequent pleural effusion

Optimization of the osmotic drying process to abtain dry products of Tommy Atkins mango

Tropical fruits like mango (Mangifera indica L.), one of the most popular fruits of the world, although very much appreciated, is highly perishable and seguire special techniques for its conservation and commercialization. This work had as objective to optimize the process of osmotic drying of mango and to study the effect of the temperature, sucrose concentration and time of immersion on the loss of water and gain in solid content. The influence of each variable and its interactions on the response were analyzed through analysis of variance (F-test and determination coefficient). It was verified that the three factors show significant effect on the loss of water and gain of mango solids, within the limits of the study. The optimum condition found for dehydration used as pretreatment for larger loss of water and smaller gain of solids was: temperature of 50 ºC, concentration of 40% and immersion time of 90 min.Frutas tropicais como a manga (Mangifera indica L.) uma das mais populares do mundo, embora muito apreciadas, são altamente perecíveis e requer técnicas especiais para sua conservação e comercialização, razão por que se objetivou otimizar seu processo de secagem osmótica e estudar o efeito da temperatura, concentração de sacarose e tempo de imersão, em relação à perda de água e ganho de sólidos. A influência de cada variável e sua interação sobre as respostas, foram avaliada através da análise de variância (teste F e coeficiente de determinação). Verificou-se que os três fatores mostraram efeito significativo quanto à perda de água e ganho de sólidos de manga, dentro das faixas estudadas. A condição ótima encontrada para desidratação utilizada como pré-tratamento para maior perda de água e menor ganho de sólidos, foi temperatura de 50 ºC, concentração de 40% e tempo de imersão de 90 min.57658

Characteristics of bile duct carcinoma with superficial extension in the epithelium.

BACKGROUND: Longitudinal tumor extension from the main tumor involves intramural or superficial spread along the bile duct, which influences surgical curability. Identifying the range of superficial extension is difficult by preoperative imaging. To clarify specific characteristics of bile duct carcinoma (BDC) with superficial extension of epithelium in the bile duct, we examined clinicopathologic features and patient outcomes in BDC patients with or without superficial extension who underwent surgical resection. METHODS: Between 1994 and 2008, we retrospectively examined clinicopathologic findings and outcomes for 42 BDC patients who underwent surgical resection and divided them into two groups: (1) superficial extension (SE) group (n = 10); and (2) non-SE group (n = 32). RESULTS: In terms of macroscopic growth of the main tumor, the papillary type was more common in the SE group than in the non-SE group, whereas the nodular type was dominant in the non-SE group. The prevalence of cancer-positive findings at the cut end of the bile duct was higher in the SE group. Portal vein invasion was not observed in the SE group, and the prevalence of regional lymph node metastasis was significantly greater in the non-SE group than in the SE group. No patients died of cancer in the SE group, who tended to show better survival than the non-SE group. CONCLUSIONS: The present results suggest that a good prognosis may be achieved in BDC patients with SE when complete resection is accomplished.The original publication is available at www.springerlink.co

Usefulness of measuring hepatic functional volume using technetium-99m galactosyl serum albumin scintigraphy in hilar bile duct carcinoma

This case involved a 75-year-old woman with obstructive jaundice who was diagnosed with hilar bile duct carcinoma. After endoscopic retrograde biliary drainage, the total bilirubin level was normalized. The indocyanine green test retention rate at 15 min (ICGR15) was 26%. The liver uptake ratio (LHL15) by technetium-99m galactosyl human serum albumin (99mTc-GSA) liver scintigraphy was 0.87. Left hepatectomy was scheduled by CT volumetry. However, biliary drainage was insufficient, and the functional liver volume showed functional deterioration of the left liver. After percutaneous transhepatic biliary drainage, future remnant liver volume by 99mTc-GSA liver scintigraphy changed to 52% from 42%, and ICGR15 and LHL15 were improved to 16% and 0.914, respectively. Scheduled left hepatectomy was performed following the results of functional liver volume. The measurement of functional volume by 99mTc-GSA liver scintigraphy provides useful information with respect to segmental liver function for deciding operative indications

Keratinocyte Growth Factor Gene Electroporation into Skeletal Muscle as a Novel Gene Therapeutic Approach for Elastase-Induced Pulmonary Emphysema in Mice

Pulmonary emphysema is a progressive disease with airspace destruction and an effective therapy is needed. Keratinocyte growth factor (KGF) promotes pulmonary epithelial proliferation and has the potential to induce lung regeneration. The aim of this study was to determine the possibility of using KGF gene therapy for treatment of a mouse emphysema model induced by porcine pancreatic elastase (PPE). Eight-week-old BALB/c male mice treated with intra-tracheal PPE administration were transfected with 80 μg of a recombinant human KGF (rhKGF)-expressing FLAG-CMV14 plasmid (pKGF-FLAG gene), or with the pFLAG gene expressing plasmid as a control, into the quadriceps muscle by electroporation. In the lung, the expression of proliferating cell nuclear antigen (PCNA) was augmented, and surfactant protein A (SP-A) and KGF receptor (KGFR) were co-expressed in PCNA-positive cells. Moreover, endogenous KGF and KGFR gene expression increased significantly by pKGF-FLAG gene transfection. Arterial blood gas analysis revealed that the PaO2 level was not significantly reduced on day 14 after PPE instillation with pKGF-FLAG gene transfection compared to that of normal mice. These results indicated that KGF gene therapy with electroporation stimulated lung epithelial proliferation and protected depression of pulmonary function in a mouse emphysema model, suggesting a possible method of treating pulmonary emphysema