Imbalance of the hemocoagulation and fibrinolysis systems under conditions of diabetes mellitus complicated by acute circulatory disturbance in the pool of carotid arteries of rats

Introduction. Both cerebral ischemia and diabetes mellitus (DM) are evidenced to be associated with hypercoagulation state, though today the facts concerning hemocoagulation condition with diabetes mellitus complicated by cerebral ischemia-reperfusion are lacking.    The aim of the study. To examine the dynamics of interrelations between the pro-, anticoagulant and fibrinolytic parameters in rats with diabetes mellitus complicated by acute cerebral circulatory disturbance.   Results. At the early ischemic-reperfusion period activation of the pro-coagulant potential (decrease of prothrombin and thrombin time and increase of fibrinogen content) is found to be balanced by a reduced activity of XIII factor and an increase activity of antithrombin III in rats without diabetes mellitus.  At the same period in rats with diabetes increase of the pro-coagulant potential is accompanied by the activation of XIII factor and a reduced activity of antithrombin III promoting clot formation. On the 12th day of the observation the parameters of the coagulation chain in the hemostasis system and antithrombin III return to the level of the control animals in rats without diabetes, but in rats with diabetes the factors of intensification of a thrombotic risk remain activated. At the early and late ischemic-reperfusion periods the parameters of blood fibrinolytic activity increase in rats without diabetes; in animals with diabetes mellitus the parameters of fibrinolytic activity remain without changes at the early period of observation (except decrease of a potential plasminogen activity), and they decrease on the 12th day of the post-ischemic period, which deteriorates conditions of thrombolysis.   Conclusions. Complication of diabetes mellitus by ischemic-reperfusion lesion of the brain results in imbalance in the hemocoagulation system at the expense of intensification of pro-coagulant mechanisms, and promotes inhibition of fibrinolytic processes with advanced changes in the dynamics of observation.   &nbsp

Symbolic Quantitative Information Flow

acmid: 2382791 issue_date: November 2012 keywords: algorithms, security, verification numpages: 5acmid: 2382791 issue_date: November 2012 keywords: algorithms, security, verification numpages: 5acmid: 2382791 issue_date: November 2012 keywords: algorithms, security, verification numpages: 5acmid: 2382791 issue_date: November 2012 keywords: algorithms, security, verification numpages: 5acmid: 2382791 issue_date: November 2012 keywords: algorithms, security, verification numpages:

Provision of production capacity of sugar plants of the Vinnytsia region

 Investigated the current state of development of sugar beet production and sugar in agricultural and processing enterprises of Vinnytsia region, the efficiency of sugar production in the agro-industrial formations and the causes of the crisis in sugar beet production. Made requirements of sugar beet for sugar plants of the Vinnytsia region on the three options for the duration of their work:75 days; 90 days; 100 days. The basic directions of increase of efficiency of activity, identified promising parameters of sugar beet production in the agricultural enterprises of Vinnytsia region. The influence of organizational-economic mechanism on the efficiency of sugar production and usigliano socio-economic importance of the sector through the related challenges.         Key words: organizational and economic mechanism, sugar beets, sugar beets production, productivity, profitability.ЗАБЕЗПЕЧЕННЯ ВИРОБНИЧИХ ПОТУЖНОСТЕЙ ЦУКРОВИХ ЗАВОДІВ ВІННИЦЬКОЇ ОБЛАСТІкандидати економічних наук, доценти  Жарун  О. В.,  Соколюк  С. Ю., Ткачук  С. П. Уманський національний університет садівництва, Україна, Умань          Досліджено сучасний стан розвитку виробництва цукрових буряків і цукру в сільськогосподарських і переробних підприємствах Вінницької області, визначено ефективність цукробурякового виробництва в аграрно-промислових формуваннях та виявлено причини кризової ситуації у цукробуряковому виробництві. Зроблено розрахунок потреби цукрових буряків для роботи цукрових заводів Вінницької області за трьома варіантами тривалості їх роботи:75 діб; 90 діб; 100 діб. Обґрунтовано напрями підвищення ефективності діяльності, визначено перспективні параметри виробництва цукрових буряків у агроформуваннях Вінницької області. Досліджено вплив організаційно-економічного механізму на ефективність функціонування цукробурякового виробництва та узагальненно суспільно-економічне значення галузі через вирішення відповідних завдань.Ключові слова: організаційно-економічний механізм, цукрові буряки, цукробурякове виробництво, урожайність, рентабельність

Violation in the axis of the "microbiota of the digestive tract-brain" under conditions of ischemia-reperfusion of the brain (literature review)

The aim of the study is to analyze current views concerning interrelations between the state of intestinal microbiota and the course of ischemic-reperfusion brain injury.   Conclusion. Literary data are indicative of disputable scientific opinions existing nowadays concerning the role of dysbacteriosis (neuroprotective or neurodegenerative) in the course of ischemic brain injuries. Meanwhile, the studies are in common concerning the evidenced role of the intestinal microbiota in disturbances of T-cell homeostasis, ratio changes of their Treg-Th17 subpopulations, and migration of intestinal lymphocytes to the ischemic brain. &nbsp

Age features of the thymocite RNA response in the thymus structural and functional areas to blood circulation disorders in the pool of carotic arteries in rats

Introduction. Ischemic-reperfusion injuries of the brain are accompanied by immunological disorders, which in their turn can extend post-ischemic changes in the brain. The studies of structural and functional changes in the thymus cells caused byischemia-reperfusion of the brain can supplement the existing understanding of the mechanism of the above interaction. The aim of the study. To investigate the reaction of thymocyte RNA in the structural and functional areas of the thymus gland to blood circulation disturbances in the carotid artery pool. Results. In rats of both age groups, cerebral ischemia-reperfusion reduces the content of RNA in the thymus cells in all the structural and functional areas of the thymus except the deep cortical one in one-month rats and the sub-capsular one in three-month rats.  Conclusions. Acute circulatory disorders in the pool of the carotid arteries result in certain changes in RNA content in all the structural and functional areas of the thymus with age-related and structural features available

State of proteolytic and fibrinolytic processes in the brain of rats with experimental diabetes mellitus complicated by cerebrovascular accident in the basin of the carotid arteries

Introduction. The imbalance in the protease-antiprotease system is an integral part of the pathogenesis of acute disorder of cerebrovascular circulation and diabetes mellitus (DM), but its manifestations in the complication of diabetes by ischemia-reperfusion of the brain have not been investigated yet. The objective of the work – to study the dynamics of carotid ischemia-reperfusion effect on the proteo- and fibrinolytic activity in brain structures of rats with experimental DM. Rats with the four-month streptozotocin DM were modeled bilateral carotene ischemia during 20 minutes. In homogenates of brain structures, indicators of proteo- fibrinolytic activity were determined after 1 hour from the beginning of reperfusion and during the 12th day of the post-ischemic period. In the absence of DM, the proteolytic activity of all or individual indicators il increased in both periods of the post-ischemic period in the cortex of the frontal and occipital lobes, the fields of hippocampus CA2 and CA3, and during the 12th day in the field CA1. Results. In rats with diabetes, in all brain structures, there are no changes in the lysis of azo-albumin and azo-casein in both terms of observation and lysis of collagen progressively decreases. In rats without DM in the cortex of the studied particles, fields of the hippocampus CA1 and CA2, all or separate indices of fibrinolytic activity are increased in both periods of the post-ischemic period, in the field CA3 – all indices at the 12th day. In the presence of diabetes in the cortex of both studied lobes and the field CA1, the fibrinolytic activity decreases in the late post-ischemic period, in the fields of CA2 and CA3 – during both observation periods. Conclusion. In the brain structures under investigation at both time intervals, the DM eliminates the reaction of low and high molecular weight proteins to the ischemia-reperfusion and suppresses fibrinolytic activity

Interaction between diabetes-associated disorders of the salivary glands and oral mucosa (literature review)

The aim of the study: to analyze literature sources concerning interaction between pathogenesis of lesions of the salivary glands and oral mucous membrane in patients suffering from diabetes mellitus (DM).  Conclusion. Analysis of the current literature is quite explicit on the point concerning interdependence of lesions of the salivary glands and morphofunctional changes of the oral mucosa with diabetes mellitus

ІННОВАЦІЙНО-ІНВЕСТИЦІЙНИЙ РОЗВИТОК АПК

The problems, possibilities and perspectives of activization of innovation and investment processes in agro-industrial complex are considered in the article. It is proved that for the intensification of agro-industrial complex the increase of its investment attraction is necessary. At the evaluation of the investment projects, the most substantial types of risks are determined. The development level of agro-industrial complex of the country that largely depends on the state of its innovative providing is researched. The amount of the inculcated new technological processes in the agro-industrial production of Ukraine over the last few years is appraised. The analysis of the development of innovative entrepreneurship and scientific and technical activity in the country is conducted and it is characterized by the following factors: firstly, by the lack of own funds for the activization of innovative activity, which is confirmed by the structure of the sources of financing of innovative activity; secondly, by the overwhelming propensity to innovative activity of large enterprises; thirdly, by the minimization of the influence of the state through budget policy on the rates and directions of the development of innovative entrepreneurship that is predefined by proof practice of slow budgetary maintenance of state scientific institutions and due to the deepening of tendencies of concentration of budgetary resources on financing of fundamental scientific research at the minimum amounts of financing of the government special-purposed  programs. Several measures for the intensification of innovation and investment activity of enterprises are proposed.В статье рассмотрены проблемы, возможности и перспективы активизации инновационно-инвестиционных процессов в АПК. Доказано, что для ускорения развития аграрно-промышленного комплекса требуется повышение его инвестиционно-инновационной привлекательности. Предложен ряд мер по активизации инновационно-инвестиционной деятельности предприятий.У статті розглянуто проблеми, можливості та перспективи активізації інноваційно-інвестиційних процесів в АПК. Доведено, що для прискорення розвитку аграрно-промислового комплексу потрібно підвищення його інвестиційно-інноваційної привабливості. Запропоновано ряд заходів щодо активізації інноваційно-інвестиційної діяльності підприємств