Changes in Coagulation Profile During Planned Laparoscopic Operations

Pneumoperitoneum may be a risk factor for venous thromboembolism. However, nowadays there is no reasonable algorithm for the prevention of thrombotic complications of laparoscopic interventions.The objective of the research was to assess the impact of laparoscopic surgery on coagulation parameters considering the number of other risk factors. The parameters of blood coagulation and thromboelastography in patients during laparoscopic cholecystectomy were investigated.Results. Blood coagulation capacity increased slightly during laparoscopic surgery. The patient’s age, body mass index and duration of surgery correlated with signs of hypercoagulability. Surgery duration had the strongest effect on coagulation parameters. In patients having no risk factors for thrombotic complications the indicators of thromboelastography did not exceeded the reference values. However, in patients with existing risk factors for thrombotic complications thromboelastogram showed significant deviations from the norm.Conclusions. Simple laparoscopic surgery did not significantly affect the risk for thrombotic complications. The age of patients over 40 years, body mass index over 30 kg/m2, duration of laparoscopic surgery more than 1 hour should be included to risk factors for venous thrombosis. Thromboelastography can be used for screening assessment of the risk for thrombotic complications in patients undergoing laparoscopic surgery

Досвід застосування малоінвазивних втручань в ургентній хірургії

On the basis of statistical indicators of the clinic work there is given a characteristics of experience of minimally invasive technologies in emergency surgery. The authors describe the surgical treatment options for various acute surgical diseases. It was indicated the necessity of organizational innovations and training. The conclusion about the need to expand the application of minimally invasive interventions in emergency surgery.На основании анализа статистических показателей работы клиники приведена характеристика опыта применения малоинвазивных технологий в ургентной хирургии. Авторы описали варианты хирургической тактики при различных острых хирургических заболеваниях. Обоснована необходимость организационных нововведений, а также подготовки специалистов. Сделан вывод о необходимости расширения применения малоинвазивных вмешательств в ургентной хирургии.На підставі аналізу статистичних показників роботи клініки наведено характеристику досвіду застосування малоінвазивних технологій в ургентній хірургії. Автори описали варіанти хірургічної тактики при різних гострих хірургічних захворюваннях. Обґрунтовано необхідність організаційних нововведень, а також підготовки фахівців. Зроблено висновок про необхідність розширення застосування малоінвазивних втручань в ургентній хірургії

Retrospective Analysis of Quality Indicators of Transduodenal Endobiliar Interventions without Anaesthesia

The objective of the research was to assess the advantages and disadvantages of transduodenal endobiliar surgeries without general anesthesia. The analysis of 1,678 hospital records of patients who underwent transduodenal endobiliar surgery was made including the average  duration of surgery, its effectiveness and the incidence of adverse cardiorespiratory events. The number of terminated procedures and subjective evaluation of the procedure by the patient and endoscopist were taken into account. Results. There has been a growth of minimally invasive operations since 2008. The analysis indicated that endoscopists refused to perform high-risk surgery in patients with high comorbidity. Choledocholitoextraction without general anesthesia was possible only in 50-75% of cases. One of the disadvantages of the procedure was psychological efforts made by physicians. The incidence of cardiorespiratory events was 1-2%, and surgery was terminated in 12 to 32% of cases. Postoperative  mortality was 0.18%, the total mortality rate was 1.8%. Conclusions. Endobiliar interventions without general anesthesia showed significant limitations and disadvantages. Intraoperative complications of cardiorespiratory system when performing endoscopic surgery without general anaesthesia were obsereved only in 2% of patients, however, this small number was achieved by careful selection of low-risk patients excluding those at risk of age-related complications and those having risky comorbidities. The absence of anaesthesia significantly reduces patient safety

WKB approximation in deformed space with minimal length

The WKB approximation for deformed space with minimal length is considered. The Bohr-Sommerfeld quantization rule is obtained. A new interesting feature in presence of deformation is that the WKB approximation is valid for intermediate quantum numbers and can be invalid for small as well as very large quantum numbers. The correctness of the rule is verified by comparing obtained results with exact expressions for corresponding spectra.Comment: 13 pages Now it is avaible at http://stacks.iop.org/0305-4470/39/37

General approach to potentials with two known levels

We present the general form of potentials with two given energy levels $E_{1}$, $E_{2}$ and find corresponding wave functions. These entities are expressed in terms of one function $\xi (x)$ and one parameter $\Delta E=E_{2}$-$E_{1}$. We show how the quantum numbers of both levels depend on properties of the function $\xi (x)$. Our approach does not need resorting to the technique of supersymmetric (SUSY) quantum mechanics but automatically generates both the potential and superpotential.Comment: 14 pages, REVTeX 3.0. In v.2 misprints and inaccuracies in presentation corrected, discussion of 3-dim. case added. In v.3 misprint in eq. 41, several typos and inaccuracies in English corrected. To be published in J. of Phys. A: Math. Ge

Supersymmetric Method for Constructing Quasi-Exactly and Conditionally-Exactly Solvable Potentials

Using supersymmetric quantum mechanics we develop a new method for constructing quasi-exactly solvable (QES) potentials with two known eigenstates. This method is extended for constructing conditionally-exactly solvable potentials (CES). The considered QES potentials at certain values of parameters become exactly solvable and can be treated as CES ones.Comment: 17 pages, latex, no figure

One dimensional Coulomb-like problem in deformed space with minimal length

Spectrum and eigenfunctions in the momentum representation for 1D Coulomb potential with deformed Heisenberg algebra leading to minimal length are found exactly. It is shown that correction due to the deformation is proportional to square root of the deformation parameter. We obtain the same spectrum using Bohr-Sommerfeld quantization condition.Comment: 11 pages, typos corrected, references adde

η\eta-weak-pseudo-Hermiticity generators and radially symmetric Hamiltonians

A class of spherically symmetric non-Hermitian Hamiltonians and their \eta-weak-pseudo-Hermiticity generators are presented. An operators-based procedure is introduced so that the results for the 1D Schrodinger Hamiltonian may very well be reproduced. A generalization beyond the nodeless states is proposed. Our illustrative examples include \eta-weak-pseudo-Hermiticity generators for the non-Hermitian weakly perturbed 1D and radial oscillators, the non-Hermitian perturbed radial Coulomb, and the non-Hermitian radial Morse models.Comment: 14 pages, content revised/regularized to cover 1D and 3D case

Associations of BCL-2 (RS17759659), CTLA-4 (RS231775), APO-1/FAS (RS2234767) genes polymorphisms with activity of proliferation and apoptosis in thyroid tissue of patients with nodular forms of goiter combined with autoimmune thyroiditis and thyroid adenoma

The study of apoptosis and proliferative activity in the thyroid gland (TG) tissue of patients with nodular goiter and autoimmune thyroiditis (NGAIT) and thyroid adenoma (TA) is based on the expression/density of Fas/FasL, BCL-2, p53, and Ki-67 markers assessment depending on the genetic polymorphisms of BCL-2 (rs17759659), CTLA-4 (rs231775) and APO-1/Fas (rs2234767) genes.Several mechanisms of thyroid cells' programmed killing are activated in NGAIT and TA with domination of Fas-induced apoptosis, which strongly associates with the BCL-2 gene's (rs17759659) promoter (F=25.33; p<0.001) and almost six fold weaker associates with the CTLA-4 gene's (rs231775) promoter (F=4.23, p=0.017). Factors that decrease the likelihood of NGAIT and TA regardless of the CTLA-4 (rs231775) and APO-1/Fas (rs2234767) genes' genotypes are the high Ki-67 density and reduction of cells containing p53 or BCL-2 proteins (OR=0.07-0.17; 95% CI OR: 0.03-0.36; p<0.001, and OR=0.08-0.11; 95% CI OR: 0.02-0.31; p<0.001, re­spectively). High expression of surface Fas and FasL in lymphoid infiltration and de­struction of thyroid cells (stronger in GG-genotype carriers of the BCL-2 gene by 18.54% (pAA=0.043) and 36.18% (pAG=0.018), respectively) indicates the initiation of the external pathway of apoptosis through the caspase mechanism (effector caspase- 8)