5 research outputs found
Recommended from our members
Usability Test of Personality Type within a Roommate Matching Website: A Case Study
We designed and built a roommate matching website, exclusively for students, which allow students to have a central point in which they can meet credible roommate candidates, search for verified housing, and easily reach out to these individuals to further their relationship, and eventually share living space. Our website aims to allow a user to search for compatible roommates not just by living habits, but by tying in the personality of candidates in reference to their own personality type. This type of personality matching in conjunction with a standard behavioral survey is the basis of the algorithm used for roommate matching. In addition to designing and building this website, we also conducted a research around two questions. First, does the idea of personality type in conjunction with living habits have the capacity to form a stronger foundation on which roommates can be selected? Second, is there a means in which we can collect this information from a user and apply it, while avoiding the typical result of survey fatigue that is inherent in existing personality quizzes? We found that majority of our respondents felt that knowing the personality compatibility would influence their decision of sharing a living space with someone. Our respondents also preferred a more visual and interactive quiz to determine personality type in comparison to questionnaires
Mapping of Translocator Protein (18 kDa) in Peripheral Sterile Inflammatory Disease and Cancer through PET Imaging
Mapping of Translocator Protein (18 kDa) in Peripheral Sterile Inflammatory Disease and Cancer through PET Imaging
Positron emission tomography (PET) imaging of the translocator 18 kDa protein (TSPO) with radioligands has become an effective means of research in peripheral inflammatory conditions that occur in many diseases and cancers. The peripheral sterile inflammatory diseases (PSIDs) are associated with a diverse group of disorders that comprises numerous enduring insults including the cardiovascular, respiratory, gastrointestinal, or musculoskeletal system. TSPO has recently been introduced as a potential biomarker for peripheral sterile inflammatory diseases (PSIDs). The major critical issue related to PSIDs is its timely characterization and localization of inflammatory foci for proper therapy of patients. As an alternative to metabolic imaging, protein imaging expressed on immune cells after activation is of great importance. The five transmembrane domain translocator protein-18 kDa (TSPO) is upregulated on the mitochondrial cell surface of macrophages during inflammation, serving as a potential ligand for PET tracers. Additionally, the overexpressed TSPO protein has been positively correlated with various tumor malignancies. In view of the association of escalated TSPO expression in both disease conditions, it is an immensely important biomarker for PET imaging in oncology and PSIDs. In this review, we summarize the most outstanding advances on TSPO-targeted PSIDs and cancer in the development of TSPO ligands as a potential diagnostic tool, specifically discussing the last five years.KEYWORDS:translocator protein inflammation PET cancer polymorphis