Glutathione (GSH) conjugates with dopamine (DA)-derived quinones to form reactive or non-reactive GSH-conjugates

In this study we demonstrate for the first time that GSH could rapidly conjugate with dopamine (DA)-derived DA-o-quinones without enzymatic catalysis to form short-lived intermediate GSH-conjugates (2-S-GSH-DA-o-quinone and 5-S-GSH-DA-o-quinone). These intermediate GSH-conjugates are unstable and would finally form reactive or non-reactive GSH-conjugates dependent on ambient reductive forces. Under insufficient reductive forces, the intermediate GSH-conjugates could cyclize spontaneously to form reactive 7-S-GSH-aminochrome (7-S-GSH-AM). The 7-S-GSH-AM is so reactive that it could further react with another GSH to form 4,7-bi-GSH-5,6-dihydroindole. Its reactivity could also abrogate tyrosinase activity in solutions. In addition, the 7-S-GSH-AM could further undergo internal rearrangement to form non-reactive 7-S-GSH-5,6-dihydroindole. From these novel findings, we propose two detrimental positive feedback loops involving accelerated DA oxidation, increased GSH consumption and impaired GSH detoxification efficiency, as the underlying chemical explanation for dopaminergic neuron degeneration in Parkinson's disease

Superconductivity in carbon nanotubes coupled to transition metal atoms

The electronic structures of zig-zag and arm-chair single-walled carbon nanotubes interacting with a transitional-metal atomic nanowire of Ni have been determined. The Ni nanowire creates a large electron density of states (DOS)at the Fermi energy. The dependence of the enhanced DOS on the spin state and positioning of the transition-metal wire(inside or outside the nanotube) is studied. Preliminary estimates of the electron-phonon interaction suggest that such systems may have a superconducting transition temperature of $\sim$ 10-50 K. The signs of superconductivity seen in ``ropes'' of nanotubes may also be related to the effect of intrinsic transition-metal impurities.Comment: 4 pages and two figure

Frequency-Reconfigurable MIMO Monopole Antenna with Wide-Continuous Tuning Range

postprin

Dual-cap Mushroom-like Metasurface used in CP Reconfigurable Monopole Antenna for Performance Enhancement

postprin

Localization of non-interacting electrons in thin layered disordered systems

Localization of electronic states in disordered thin layered systems with b layers is studied within the Anderson model of localization using the transfer-matrix method and finite-size scaling of the inverse of the smallest Lyapunov exponent. The results support the one-parameter scaling hypothesis for disorder strengths W studied and b=1,...,6. The obtained results for the localization length are in good agreement with both the analytical results of the self-consistent theory of localization and the numerical scaling studies of the two-dimensional Anderson model. The localization length near the band center grows exponentially with b for fixed W but no localization-delocalization transition takes place.Comment: 6 pages, 5 figure

Asserting rights, defining responsibilities: perspectives from small-scale fishing communities on coastal and fisheries management in Cambodia

In preparation for the Workshop and Symposium on “Asserting Rights, Defining Responsibilities: Perspectives from Small-scale Fishing Communities on Coastal and Fisheries Management in Asia”, held in Siem Reap Cambodia, from 3 to 8 May 2007, case studies were undertaken in six countries in Asia—Bangladesh, Cambodia, India, Indonesia, Philippines and Thailand. Among other things, the studies aimed to document and explore the understanding that fishing communities have about their rights to fisheries and coastal resources, as well as the obligations and responsibilities associated with these rights, and to document and discuss their initiatives to assert these rights and fulfill their responsibilities. The studies formed the basis for discussions at the Workshop and Symposium. This case study from Cambodia will be found useful by NGOs, regional and national organizations of artisanal fishworkers, and anyone interested in fisheries and fishing communities in Cambodia

Coulomb interactions of massless Dirac fermions in graphene; pair-distribution functions and exchange-driven spin-polarized phases

The quasi-2D electrons in graphene behave as massless fermions obeying a Dirac-Weyl equation in the low-energy regime near the two Fermi points. The stability of spin-polarized phases (SPP) in graphene is considered. The exchange energy is evaluated from the analytic pair-distribution functions, and the correlation energies are estimated via a closely similar four-component 2D electron fluid which has been investigated previously. SPPs appear for sufficiently high doping, when the exchange energy alone is considered. However, the inclusion of correlations is found to {\it suppress} the spin-phase transition in ideal graphene.Comment: 5 pages, 3 figures, Revte

Theory of band gap bowing of disordered substitutional II-VI and III-V semiconductor alloys

For a wide class of technologically relevant compound III-V and II-VI semiconductor materials AC and BC mixed crystals (alloys) of the type A(x)B(1-x)C can be realized. As the electronic properties like the bulk band gap vary continuously with x, any band gap in between that of the pure AC and BC systems can be obtained by choosing the appropriate concentration x, granted that the respective ratio is miscible and thermodynamically stable. In most cases the band gap does not vary linearly with x, but a pronounced bowing behavior as a function of the concentration is observed. In this paper we show that the electronic properties of such A(x)B(1-x)C semiconductors and, in particular, the band gap bowing can well be described and understood starting from empirical tight binding models for the pure AC and BC systems. The electronic properties of the A(x)B(1-x)C system can be described by choosing the tight-binding parameters of the AC or BC system with probabilities x and 1-x, respectively. We demonstrate this by exact diagonalization of finite but large supercells and by means of calculations within the established coherent potential approximation (CPA). We apply this treatment to the II-VI system Cd(x)Zn(1-x)Se, to the III-V system In(x)Ga(1-x)As and to the III-nitride system Ga(x)Al(1-x)N.Comment: 14 pages, 10 figure

Electric fields and valence band offsets at strained [111] heterojunctions

[111] ordered common atom strained layer superlattices (in particular the common anion GaSb/InSb system and the common cation InAs/InSb system) are investigated using the ab initio full potential linearized augmented plane wave (FLAPW) method. We have focused our attention on the potential line-up at the two sides of the homopolar isovalent heterojunctions considered, and in particular on its dependence on the strain conditions and on the strain induced electric fields. We propose a procedure to locate the interface plane where the band alignment could be evaluated; furthermore, we suggest that the polarization charges, due to piezoelectric effects, are approximately confined to a narrow region close to the interface and do not affect the potential discontinuity. We find that the interface contribution to the valence band offset is substantially unaffected by strain conditions, whereas the total band line-up is highly tunable, as a function of the strain conditions. Finally, we compare our results with those obtained for [001] heterojunctions.Comment: 18 pages, Latex-file, to appear in Phys.Rev.

Optimal test designs with content balancing and variable target information functions as constraints.

Optimal test design involves the application of an item selection heuristic to construct a test to fit the target information function in order that the standard error of the test can be controlled at different regions of the ability continuum. The real data simulation study assessed the efficiency of binary programming in optimal item selection by comparing the degree in which the obtained test information was approximated to different target information functions with a manual heuristic. The effects of imposing a content balancing constraint was studied in conventional, two-stage and adaptive tests designed using the automated procedure. Results showed that the automated procedure improved upon the manual procedure significantly when a uniform target information function was used. However, when a peaked target information function was used, the improvement over the manual procedure was marginal. Both procedures were affected by the distribution of the item parameters in the item pool. The degree in which the examinee empirical scores were recovered was lower when a content balancing constraint was imposed in the conventional test designs. The effect of uneven item parameter distribution in the item pool was shown by the poorer recovery of the empirical scores at the higher regions of the ability continuum. Two-stage tests were shown to limit the effects of content balancing. Content balanced adaptive tests using optimal item selection was shown to be efficient in empirical score recovery, especially in maintaining equiprecision in measurement over a wide ability range despite the imposition of content balancing constraint in the test design. The study had implications for implementing automated test designs in the school systems supported by hardware and expertise in measurement theory and addresses the issue of content balancing using optimal test designs within an adaptive testing framework