ORAL TREATMENT OF HEMOPHILIA

Disclosed herein is a simple method for the treatment of antigen-deficiency diseases, by orally administering to a subject a therapeutically effective amount of the deficient antigen, wherein the antigen is not present in a liposome. In one embodiment, the method increases hemostasis in a subject having hemophilia A or B, by orally administering to the hemophiliac a therapeutically effective amount of the appropriate clotting factor other than in a liposome, sufficient to induce oral tolerance and supply exogenous clotting factor to the subject

INDUCTION OF TOLERANCE BY ORAL ADMINISTRATION OF FACTOR VIII AND TREATMENT OF HEMOPHILA

Disclosed herein is a simple method for the treatment of antigen-deficiency diseases, by orally administering to a Subject a therapeutically effective amount of the deficient anti gen, wherein the antigen is not present in a liposome. In one embodiment, the method increases hemostasis in a subject having hemophilia A or B, by orally administering to the hemophiliac atherapeutically effective amount of the appropriate clotting factor other than in a liposome, Sufficient to induce oral tolerance and Supply exogenous clotting factor to the subject

Analysis of minimization algorithms for multiple-valued programmable logic arrays

This publication is a work of the U.S. Government as defined in Title 17, United States Code, Section 101. As such, it is in the public domain, and under the provisions of Title 17, United States Code, Section 105, may not be copyrighted.Proceedings of the 18th International Symposium on Multiple-Valued Logic, May 1988, pp. 226-236We compare the performance of three heuristic algorithms [3,6,13] for the minimization of sum-of-products expressions realized by the newly developed multiplevalued programmable logic arrays [9]. Heuristic methods are important because exact minimization is extremely time consuming. We compare the heuristics to the exact solution, showing that heuristic methods are reasonably close to minimal. We use as a basis of comparison the average number of product terms over a set of randomly generated functions. All three heuristics produce nearly the same average number of product terms. Although the averages are close, there is surprisingly little overlap among the set of functions where the best realization is achieved. Thus, there is a benefit to applying different heuristics and then choosing the best realization

The β-glucoside genes of Klebsiella aerogenes: conservation and divergence in relation to the cryptic bgl genes of Escherichia coli

The ability to metabolize aromatic β-glucosides such as salicin and arbutin varies among members of the Enterobacteriaceae. The ability of Escherichia coli to degrade salicin and arbutin appears to be cryptic, subject to activation of the bgl genes, whereas many members of the Klebsiella genus can metabolize these sugars. We have examined the genetic basis for β-glucoside utilization in Klebsiella aerogenes. The Klebsiella equivalents of bglG, bglB and bglR have been cloned using the genome sequence database of Klebsiella pneumoniae. Nucleotide sequencing shows that the K. aerogenes bgl genes show substantial similarities to the E. coli counterparts. The K. aerogenes bgl genes in multiple copies can also complement E. coli mutants deficient in bglG encoding the antiterminator and bglB encoding the phospho-β-glucosidase, suggesting that they are functional homologues. The regulatory region bglR of K. aerogenes shows a high degree of similarity of the sequences involved in BglG-mediated regulation. Interestingly, the regions corresponding to the negative elements present in the E. coli regulatory region show substantial divergence in K. aerogenes. The possible evolutionary implications of the results are discussed

Approximate Dynamic Programming for a Mean-field Game of Traffic Flow: Existence and Uniqueness

Highway vehicular traffic is an inherently multi-agent problem. Traffic jams can appear and disappear mysteriously. We develop a method for traffic flow control that is applied at the vehicular level via mean-field games. We begin this work with a microscopic model of vehicles subject to control input, disturbances, noise, and a speed limit. We formulate a discounted-cost infinite-horizon robust mean-field game on the vehicles, and obtain the associated dynamic programming (DP) PDE system. We then perform approximate dynamic programming (ADP) using these equations to obtain a sub-optimal control for the traffic density adaptively. The sub-optimal controls are subject to an ODE-PDE system. We show that the ADP ODE-PDE system has a unique weak solution in a suitable Hilbert space using semigroup and successive approximation methods. We additionally give a numerical simulation, and interpret the results.Comment: 42 pages, 5 figure

Weak Solutions to an Euler Alignment System in a Bounded Domain

Euler alignment systems appear as hydrodynamic limits of interacting self-propelled particle systems such as the (generalized) Cucker-Smale model. In this work, we study weak solutions to an Euler alignment system on smooth, bounded domains. This particular Euler alignment system includes singular alignment, attraction, and repulsion interaction kernels which correspond to a Yukawa potential. We also include a confinement potential and self-propulsion. We embed the problem into an abstract Euler system to conclude that infinitely many weak solutions exist. We further show that we can construct solutions satisfying bounds on an energy quantity, and that the solutions satisfy a weak-strong uniqueness principle. Finally, we present an addition of leader-agents governed by controlled ODEs, and modification of the interactions to be Bessel potentials of fractional order $s > 2$

Asymmetric Supercapacitor for Long-Duration Power Storage

A document discusses a project in which a series of novel hybrid positive electrode materials was developed and tested in asymmetric capacitors with carbon negative electrodes. The electrochemical performance of the hybrid capacitors was characterized by cyclic voltammetry and a DC charge/discharge test. The hybrid capacitor exhibited ideal capacitor behavior with an extended operating voltage of 1.6 V in aqueous electrolyte, and energy density higher than activated carbon-based supercapacitors. Nanostructured MnO2 is a promising material for electrochemical capacitors (ECS) because of its low cost, environmentally friendly nature, and reasonably high specific capacitance. The charge capacity of the capacitors can be further improved by increasing the specific surface area of the MnO2 electrode material. The power density and space radiation stability of the capacitors can be enhanced by coating the MnO2 nanoparticles with conducting polymers. The conducting polymer coating also helps in radiation-hardening the ECS

ORAL TREATMENT OF HEMOPHILIA

Disclosed herein is a simple method for the treatment of antigen-deficiency diseases, by orally administering to a subject a therapeutically effective amount of the deficient antigen, wherein the antigen is not present in a liposome. In one embodiment, the method increases hemostasis in a subject having hemophilia A or B, by orally administering to the hemophiliac a therapeutically effective amount of the appropriate clotting factor other than in a liposome, sufficient to induce oral tolerance and supply exogenous clotting factor to the subject

A well-characterised peak identification list of MALDI MS profile peaks for human blood serum

MALDI MS profiling, using easily available body fluids such as blood serum, has attracted considerable interest for its potential in clinical applications. Despite the numerous reports on MALDI MS profiling of human serum, there is only scarce information on the identity of the species making up these profiles, particularly in the mass range of larger peptides. Here, we provide a list of more than 90 entries of MALDI MS profile peak identities up to 10 kDa obtained from human blood serum. Various modifications such as phosphorylation were detected among the peptide identifications. The overlap with the few other MALDI MS peak lists published so far was found to be limited and hence our list significantly extends the number of identified peaks commonly found in MALDI MS profiling of human blood serum