Quantum interference in dirty d-wave superconductors

The local differential tunneling conductance on a Zn impurity in a disordered d-wave superconductors is studied. Quantum interference between many impurities leads to definitive quasiparticle spectra. We suggest that an elaborate analysis on impurity-induced spectra with quantum interference effect included may be able to pin down the sign and strength of the scattering potential of a Zn impurity in low density limit. Numerical simulations calculated with appropriately determined impurity parameters are in satisfactory agreement with the observations from scanning tunneling microscopy (STM) experiments even in subtle details

Cascades of Dynamical Transitions in an Adaptive Population

In an adaptive population which models financial markets and distributed control, we consider how the dynamics depends on the diversity of the agents' initial preferences of strategies. When the diversity decreases, more agents tend to adapt their strategies together. This change in the environment results in dynamical transitions from vanishing to non-vanishing step sizes. When the diversity decreases further, we find a cascade of dynamical transitions for the different signal dimensions, supported by good agreement between simulations and theory. Besides, the signal of the largest step size at the steady state is likely to be the initial signal.Comment: 4 pages, 8 figure

Kinetic considerations of the strength of oriented solids

Kinetics of mechanical strength of oriented and stressed solids based on statistical absolute reaction rate theor

Fabrication of a focusing soft X-ray collector payload

A large area X-ray focusing collector with arc minute resolution and a position sensitive detector capable of operating in the soft X-ray region was developed for use on sounding rockets in studying stellar X-ray sources. The focusing payload consists of the following components, which are described: (1) a crossed paraboloid mirror assembly; (2) an aspect camera and star tracker; (3) a focal plane assembly containing an imaging proportional counter and its preamplifiers, high voltage power supplies and gas system; (4) a fiducial system; and (5) housekeeping, data handling, instrumentation and telemetry electronics. The design, tests, and operation are described

In vitro and in vivo studies of the trypanocidal properties of WRR-483 against Trypanosoma cruzi.

BackgroundCruzain, the major cysteine protease of Trypanosoma cruzi, is an essential enzyme for the parasite life cycle and has been validated as a viable target to treat Chagas' disease. As a proof-of-concept, K11777, a potent inhibitor of cruzain, was found to effectively eliminate T. cruzi infection and is currently a clinical candidate for treatment of Chagas' disease.Methodology/principal findingsWRR-483, an analog of K11777, was synthesized and evaluated as an inhibitor of cruzain and against T. cruzi proliferation in cell culture. This compound demonstrates good potency against cruzain with sensitivity to pH conditions and high efficacy in the cell culture assay. Furthermore, WRR-483 also eradicates parasite infection in a mouse model of acute Chagas' disease. To determine the atomic-level details of the inhibitor interacting with cruzain, a 1.5 A crystal structure of the protease in complex with WRR-483 was solved. The structure illustrates that WRR-483 binds covalently to the active site cysteine of the protease in a similar manner as other vinyl sulfone-based inhibitors. Details of the critical interactions within the specificity binding pocket are also reported.ConclusionsWe demonstrate that WRR-483 is an effective cysteine protease inhibitor with trypanocidal activity in cell culture and animal model with comparable efficacy to K11777. Crystallographic evidence confirms that the mode of action is by targeting the active site of cruzain. Taken together, these results suggest that WRR-483 has potential to be developed as a treatment for Chagas' disease

Topological Phases in Neuberger-Dirac operator

The response of the Neuberger-Dirac fermion operator D=\Id + V in the topologically nontrivial background gauge field depends on the negative mass parameter $m_0$ in the Wilson-Dirac fermion operator $D_w$ which enters $D$ through the unitary operator $V = D_w (D_w^{\dagger} D_w)^{-1/2}$. We classify the topological phases of $D$ by comparing its index to the topological charge of the smooth background gauge field. An exact discrete symmetry in the topological phase diagram is proved for any gauge configurations. A formula for the index of D in each topological phase is derived by obtaining the total chiral charge of the zero modes in the exact solution of the free fermion propagator.Comment: 27 pages, Latex, 3 figures, appendix A has been revise

Coherence controlled soliton interactions

We demonstrate theoretically and subsequently observe in experiment a novel type of soliton interaction when a pair of closely spaced spatial optical solitons as a whole is made partially incoherent. We explain how the character of the soliton interaction can be controlled by the total partial incoherence, and show a possibility to change the soliton interaction from attractive to repulsive, or vice versa, near a certain threshold in the coherence parameter.Comment: 4 pages, 4 figure

Perturbed Three Vortex Dynamics

It is well known that the dynamics of three point vortices moving in an ideal fluid in the plane can be expressed in Hamiltonian form, where the resulting equations of motion are completely integrable in the sense of Liouville and Arnold. The focus of this investigation is on the persistence of regular behavior (especially periodic motion) associated to completely integrable systems for certain (admissible) kinds of Hamiltonian perturbations of the three vortex system in a plane. After a brief survey of the dynamics of the integrable planar three vortex system, it is shown that the admissible class of perturbed systems is broad enough to include three vortices in a half-plane, three coaxial slender vortex rings in three-space, and `restricted' four vortex dynamics in a plane. Included are two basic categories of results for admissible perturbations: (i) general theorems for the persistence of invariant tori and periodic orbits using Kolmogorov-Arnold-Moser and Poincare-Birkhoff type arguments; and (ii) more specific and quantitative conclusions of a classical perturbation theory nature guaranteeing the existence of periodic orbits of the perturbed system close to cycles of the unperturbed system, which occur in abundance near centers. In addition, several numerical simulations are provided to illustrate the validity of the theorems as well as indicating their limitations as manifested by transitions to chaotic dynamics.Comment: 26 pages, 9 figures, submitted to the Journal of Mathematical Physic