Incorporating family function into chronic pain disability: the role of catastrophizing

Background. Observers' responses to pain are recently investigated to more comprehensively explain chronic pain (CP) and disability. However, the role of family context, defined as interference in roles, communication, and problem-solving, and how (i.e., through which mechanisms) these variables contribute to CP related disability have yet to be examined. Objectives. The aim of the present study is to examine family context in relationship to pain catastrophizing, fear of movement, and depression and its role in understanding CP disability. Three different models were examined. Methods. A total sample of 142 patients with musculoskeletal chronic pain was recruited to examine the role of fear of movement, pain intensity, pain catastrophizing, and depression in relationship to family functioning as predictors of disability. Results. Findings indicated that two models showed acceptable fit, but one of them revealed superior fit indices. Results of the model with superior fit indices indicated that family dysfunction may contribute to catastrophic thinking, which, in turn, contributes to patients' disability through increasing fear of movement and depression. Discussion. The current study provides further support for the notion that the impact of emotional and cognitive variables upon CP-related disability can be better understood when we consider the social context of pain patients and family function in particular

Hubungan Antara Konsep Diri Dengan Keefektivan Komunikasi Antarpribadi: Studi Pada Anggota Aiesec Local Committee (Lc) Bandung

Konsep diri merupakan faktor yang sangat menentukan dalam komunikasi antarpribadi, karena setiap orang bertingkah laku sedapat mungkin sesuai dengan konsep dirinya. Setiap manusia memiliki konsep diri, maka hal tersebut juga berlaku pada anggota AIESEC Local Commitee (LC) Bandung. Metode korelasional digunakan untuk mengetahui sejauhmana hubungan antara konsep diri anggota AIESEC dengan keefektifan komunikasi antarpribadi.Populasi penelitian ini adalah anggota AIESEC Local Committee (LC) Bandung. Sampel penelitian diperoleh dengan menggunakan teknik sampling acak (random). Hasil penelitian menunjukkan hubungan antara konsep diri anggota AIESEC dengan keefektifan komunikasi antarpribadi adalah sangat kuat dengan koefisien korelasi 0,839. Nilai korelasi positif menunjukkan hubungan yang searah. Uji hipotesis menghasilkan penolakan H0 sehingga terdapat hubungan yang signifikan diantara keduanya

A new species of Gyrodactylus (Monogenea, Gyrodactylidae), an ectoparasite from the endemic Iranocichla hormuzensis (Teleostei, Cichlidae), the only Iranian cichlid

Iranocichla hormuzensis occupies a biogeographically peculiar position. This endemic of southern Iran is the only Iranian cichlid. While it is phylogenetically related to African oreochromine members of the cichlid family, it remains unclear how it has dispersed into its current range. It is one of the many lasting enigmas of cichlid biogeography. Monogenean fish parasites may provide useful additional information in such cases. Therefore, I. hormuzensis was examined for these flatworms. A gyrodactylid parasite is reported and compared to congeners from the Palearctic and from cichlids. In this way, we verify whether it shows affinities to parasites from fishes that are either biogeographically or phylogenetically close to Iranocichla hormuzensis. The species is new to science and is described as Gyrodactylus jalalii sp. nov. This is the first description of a parasite infecting I. hormuzensis. Because of the fixation method or age of the material, DNA could not be isolated. Due to the lack of genetic data, no conclusions can be drawn on its phylogenetic positioning. Indeed, Gyrodactylus phylogeny cannot be inferred from morphological characteristics alone. Moreover, the congeners phenotypically reminiscent of the new species belong to a Gyrodactylus clade which is highly diverse in geographic range and host choice. Hence, there is no evidence linking the new species to an exclusively African or cichlid-bound Gyrodactylus lineage

Pathogenesis and current treatment of osteosarcoma: Perspectives for future therapies

Osteosarcoma is the most common primary malignant bone tumor in children and young adults. The standard-of-care curative treatment for osteosarcoma utilizes doxorubicin, cisplatin, and high-dose methotrexate, a standard that has not changed in more than 40 years. The development of patient-specific therapies requires an in-depth understanding of the unique genetics and biology of the tumor. Here, we discuss the role of normal bone biology in osteosarcomagenesis, highlighting the factors that drive normal osteoblast production, as well as abnormal osteosarcoma development. We then describe the pathology and current standard of care of osteosarcoma. Given the complex heterogeneity of osteosarcoma tumors, we explore the development of novel therapeutics for osteosarcoma that encompass a series of molecular targets. This analysis of pathogenic mechanisms will shed light on promising avenues for future therapeutic research in osteosarcoma