Nonlocality and information flow: The approach of Deutsch and Hayden

Deutsch and Hayden claim to have provided an account of quantum mechanics which is particularly local, and which clarifies the nature of information transmission in entangled quantum systems. In this paper, a perspicuous description of their formalism is offered and their claim assessed. It proves essential to distinguish, as Deutsch and Hayden do not, between two ways of interpreting the formalism. On the first, conservative, interpretation, no benefits with respect to locality accrue that are not already available on either an Everettian or a statistical interpretation; and the conclusions regarding information flow are equivocal. The second, ontological, interpretation, offers a framework with the novel feature that global properties of quantum systems are reduced to local ones; but no conclusions follow concerning information flow in more standard quantum mechanics.Comment: 26 pages, LaTeX, uses amsmath; 4 .eps figure

Philosophical Aspects of Quantum Information Theory

Quantum information theory represents a rich subject of discussion for those interested in the philosphical and foundational issues surrounding quantum mechanics for a simple reason: one can cast its central concerns in terms of a long-familiar question: How does the quantum world differ from the classical one? Moreover, deployment of the concepts of information and computation in novel contexts hints at new (or better) means of understanding quantum mechanics, and perhaps even invites re-assessment of traditional material conceptions of the basic nature of the physical world. In this paper I review some of these philosophical aspects of quantum information theory, begining with an elementary survey of the theory, seeking to highlight some of the principles and heuristics involved. We move on to a discussion of the nature and definition of quantum information and deploy the findings in discussing the puzzles surrounding teleportation. The final two sections discuss, respectively, what one might learn from the development of quantum computation (both about the nature of quantum systems and about the nature of computation) and consider the impact of quantum information theory on the traditional foundational questions of quantum mechanics (treating of the views of Zeilinger, Bub and Fuchs, amongst others).Comment: LaTeX; 55pp; 3 figs. Forthcoming in Rickles (ed.) The Ashgate Companion to the New Philosophy of Physic

Entanglement and Relativity

In this paper we survey, in an elementary fashion, some of the questions that arise when one considers how entanglement and relativity are related via the notion of non-locality. We begin by reviewing the role of entangled states in Bell inequality violation and question whether the associated notions of non-locality lead to problems with relativity. The use of entanglement and wavefunction collapse in Einstein's famous incompleteness argument is then considered, before we go on to see how the issue of non-locality is transformed if one considers quantum mechanics without collapse to be a complete theory, as in the Everett interpretation. The opportunity is taken to consider whether teleportation and dense coding might constitute a source of non-locality within the Everett interpretation.Comment: 18 pages, uses amsmath, amsfonts, natbib and fancyheadings packages. Typos corrected and additional referenc

Quantum Mechanics on Spacetime I: Spacetime State Realism

What ontology does realism about the quantum state suggest? The main extant view in contemporary philosophy of physics is wave-function realism. We elaborate the sense in which wave-function realism does provide an ontological picture; and defend it from certain objections that have been raised against it. However, there are good reasons to be dissatisfied with wave-function realism, as we go on to elaborate. This motivates the development of an opposing picture: what we call spacetime state realism; a view which takes the states associated to spacetime regions as fundamental. This approach enjoys a number of beneficial features, although, unlike wave-function realism, it involves non-separability at the level of fundamental ontology. We investigate the pros and cons of this non-separability, arguing that it is a quite acceptable feature; even one which proves fruitful in the context of relativistic covariance. A companion paper discusses the prospects for combining a spacetime-based ontology with separability, along lines suggested by Deutsch and HaydenComment: LaTeX; 29 pages, 1 Fig. Forthcoming in the British Journal for the Philosophy of Scienc

Targeting ROCK activity to disrupt and prime pancreatic cancer for chemotherapy

Pancreatic ductal adenocarcinoma (PDAC) is a devastating disease; the identification of novel targets and development of effective treatment strategies are urgently needed to improve patient outcomes. Remodeling of the pancreatic stroma occurs during PDAC development, which drives disease progression and impairs responses to therapy. The actomyosin regulatory ROCK1 and ROCK2 kinases govern cell motility and contractility, and have been suggested to be potential targets for cancer therapy, particularly to reduce the metastatic spread of tumor cells. However, ROCK inhibitors are not currently used for cancer patient treatment, largely due to the overwhelming challenge faced in the development of anti-metastatic drugs, and a lack of clarity as to the cancer types most likely to benefit from ROCK inhibitor therapy. In 2 recent publications, we discovered that ROCK1 and ROCK2 expression were increased in PDAC, and that increased ROCK activity was associated with reduced survival and PDAC progression by enabling extracellular matrix (ECM) remodeling and invasive growth of pancreatic cancer cells. We also used intravital imaging to optimize ROCK inhibition using the pharmacological ROCK inhibitor fasudil (HA-1077), and demonstrated that short-term ROCK targeting, or ‘priming’, improved chemotherapy efficacy, disrupted cancer cell collective movement, and impaired metastasis. This body of work strongly indicates that the use of ROCK inhibitors in pancreatic cancer therapy as ‘priming’ agents warrants further consideration, and provides insights as to how transient mechanical manipulation, or fine-tuning the ECM, rather than chronic stromal ablation might be beneficial for improving chemotherapeutic efficacy in the treatment of this deadly disease

Why special relativity should not be a template for a fundamental reformulation of quantum mechanics

In a comparison of the principles of special relativity and of quantum mechanics, the former theory is marked by its relative economy and apparent explanatory simplicity. A number of theorists have thus been led to search for a small number of postulates - essentially information theoretic in nature - that would play the role in quantum mechanics that the relativity principle and the light postulate jointly play in Einstein's 1905 special relativity theory. The purpose of the present paper is to resist this idea, at least in so far as it is supposed to reveal the fundamental form of the theory. It is argued that the methodology of Einstein's 1905 theory represents a victory of pragmatism over explanatory depth; and that its adoption only made sense in the context of the chaotic state state of physics at the start of the 20th century - as Einstein well knew

Non-locality and gauge freedom in Deutsch and Hayden's formulation of quantum mechanics

Deutsch and Hayden have proposed an alternative formulation of quantum mechanics which is completely local. We argue that their proposal must be understood as having a form of `gauge freedom' according to which mathematically distinct states are physically equivalent. Once this gauge freedom is taken into account, their formulation is no longer local