Representing whose access and allocation interests? Stakeholder perceptions and interests representation in climate governance

This chapter presents a synthesis of findings from quantitative and qualitative investigations of the perspectives of participants involved in international climate governance, conducted over the period 2010-2015. In this study, an established framework of principles, criteria and indicators (PC&I) for institutional governance was applied to two mechanisms under the United Nations Framework Convention on Climate Change (UNFCCC): the initiative referred to as ‘Reducing emissions from deforestation and forest degradation and the role of conservation, sustainable management of forests, and enhancement of forest stocks in developing countries’ (REDD+); and the Clean Development Mechanism (CDM) of the Kyoto Protocol (KP). Assessment focuses on the governance value of interest representation in terms of inclusiveness (access) and resources (allocation). It begins by outlining the historical context of UNFCCC, as well as CDM and REDD+, and continues with a delineation of the methods adopted, and results to reveal a relatively consistent set of results across the elements investigated, with inclusiveness receiving the highest score of all the governance indicators, and resources the lowest. The CDM was the weakest performer

Arbitrarily Large Continuous-Variable Cluster States from a Single Quantum Nondemolition Gate

We present a compact experimental design for producing an arbitrarily large optical continuous-variable cluster state using just one single-mode vacuum squeezer and one quantum nondemolition gate. Generating the cluster state and computing with it happen simultaneously: more entangled modes become available as previous modes are measured, thereby making finite the requirements for coherence and stability even as the computation length increases indefinitely.Comment: (v2) 5 pages, 4 color figures, added brief mention of fault tolerance, version accepted for publication (note: actual published version is edited slightly for space); (v1) 4 pages, 4 color figure

The MASSIVE Survey - III. Molecular gas and a broken Tully-Fisher relation in the most massive early-type galaxies

In this work we present CO(1-0) and CO(2-1) observations of a pilot sample of 15 early-type galaxies (ETGs) drawn from the MASSIVE galaxy survey, a volume-limited integral-field spectroscopic study of the most massive ETGs ($M_* >10^{11.5}M_\odot$) within 108 Mpc. These objects were selected because they showed signs of an interstellar medium and/or star formation. A large amount of gas ($>$2$\times$10$^8$ M$_{\odot}$) is present in 10 out of 15 objects, and these galaxies have gas fractions higher than expected based on extrapolation from lower mass samples. We tentatively interpret this as evidence that stellar mass loss and hot halo cooling may be starting to play a role in fuelling the most massive galaxies. These MASSIVE ETGs seem to have lower star-formation efficiencies (SFE=SFR/M$_{\rm H2}$) than spiral galaxies, but the SFEs derived are consistent with being drawn from the same distribution found in other lower mass ETG samples. This suggests that the SFE is not simply a function of stellar mass, but that local, internal processes are more important for regulating star formation. Finally we used the CO line profiles to investigate the high-mass end of the Tully-Fisher relation (TFR). We find that there is a break in the slope of the TFR for ETGs at high masses (consistent with previous studies). The strength of this break correlates with the stellar velocity dispersion of the host galaxies, suggesting it is caused by additional baryonic mass being present in the centre of massive ETGs. We speculate on the root cause of this change and its implications for galaxy formation theories.Comment: 13 pages, 7 figures, accepted by MNRA

RGS10 shapes the hemostatic response to injury through its differential effects on intracellular signaling by platelet agonists.

Platelets express ≥2 members of the regulators of G protein signaling (RGS) family. Here, we have focused on the most abundant, RGS10, examining its impact on the hemostatic response in vivo and the mechanisms involved. We have previously shown that the hemostatic thrombi formed in response to penetrating injuries consist of a core of fully activated densely packed platelets overlaid by a shell of less-activated platelets responding to adenosine 5\u27-diphosphate (ADP) and thromboxane A2 (TxA2). Hemostatic thrombi formed in RGS10-/- mice were larger than in controls, with the increase due to expansion of the shell but not the core. Clot retraction was slower, and average packing density was reduced. Deleting RGS10 had agonist-specific effects on signaling. There was a leftward shift in the dose/response curve for the thrombin receptor (PAR4) agonist peptide AYPGKF but no increase in the maximum response. This contrasted with ADP and TxA2, both of which evoked considerably greater maximum responses in RGS10-/- platelets with enhanced Gq- and Gi-mediated signaling. Shape change, which is G13-mediated, was unaffected. Finally, we found that free RGS10 levels in platelets are actively regulated. In resting platelets, RGS10 was bound to 2 scaffold proteins: spinophilin and 14-3-3γ. Platelet activation caused an increase in free RGS10, as did the endothelium-derived platelet antagonist prostacyclin. Collectively, these observations show that RGS10 serves as an actively regulated node on the platelet signaling network, helping to produce smaller and more densely packed hemostatic thrombi with a greater proportion of fully activated platelets

The foreclosure crisis in 2008: predatory lending or household overreaching?

At least early in the financial crisis, the high rate of foreclosures seemed to be due more to households' overreaching than to predatory lending. A disproportionate number of those being foreclosed on were well-educated, well-off and relatively young people.Foreclosure ; Mortgage loans ; Housing - Finance

Airborne Particles in Museums

Presents one in a series of research activities aimed at a better understanding of the origin and fate of air pollution within the built environment

Demonstration of 10.7-Gb/s transmission in 50-km PON with uncooled free-running 1550-nm VCSEL

First-known demonstration of an uncooled, free-running 1550 nm VCSEL at 10.7 Gb/s over 50 km PON uplink with 35 km SMF and 15 km inverse dispersion fiber, achieving 24 dB margin for 10−9 BER

Zika virus preferentially replicates in the female reproductive tract after vaginal inoculation of rhesus macaques.

Zika virus (ZIKV) is a mosquito-transmitted virus that can cause severe defects in an infected fetus. ZIKV is also transmitted by sexual contact, although the relative importance of sexual transmission is unclear. To better understand the role of sexual transmission in ZIKV pathogenesis, a nonhuman primate (NHP) model of vaginal transmission was developed. ZIKV was readily transmitted to mature cycling female rhesus macaque (RM) by vaginal inoculation with 104-106 plaque-forming units (PFU). However, there was variability in susceptibility between the individual RM with 1->8 vaginal inoculations required to establish infection. After treatment with Depoprovera, a widely used contraceptive progestin, two RM that initially resisted 8 vaginal ZIKV inoculations became infected after one ZIKV inoculation. Thus, Depoprovera seemed to enhance susceptibility to vaginal ZIKV transmission. Unexpectedly, the kinetics of virus replication and dissemination after intravaginal ZIKV inoculation were markedly different from RM infected with ZIKV by subcutaneous (SQ) virus inoculation. Several groups have reported that after SQ ZIKV inoculation vRNA is rapidly detected in blood plasma with vRNA less common in urine and saliva and only rarely detected in female reproductive tract (FRT) secretions. In contrast, in vaginally inoculated RM, plasma vRNA is delayed for several days and ZIKV replication in, and vRNA shedding from, the FRT was found in all 6 animals. Further, after intravaginal transmission ZIKV RNA shedding from FRT secretions was detected before or simultaneously with plasma vRNA, and persisted for at least as long. Thus, ZIKV replication in the FRT was independent of, and often preceded virus replication in the tissues contributing to plasma vRNA. These results support the conclusion that ZIKV preferentially replicates in the FRT after vaginal transmission, but not after SQ transmission, and raise the possibility that there is enhanced fetal infection and pathology after vaginal ZIKV transmission compared to a mosquito transmitted ZIKV