Dari Trainer, Imam Ibadah Hingga Patronase Spiritual : Pelayanan Kbih Al-hikmah Kepada Calon/ Jamaah Haji di Kabupaten Brebes

Some people stated that the roles of KBIH and its services toward pil­grims are questionable. Several KBIHs have been changed to businessinstitution rather than social institution. There is a kind of comodi.ficationof it. This paper argues, based on field research, that KBIH al-Hikmahhas given satisfied services to pilgrims. The services were not only inthe preparation of pilgrimages (manasik), but also during the pilgrim­ages in Mecca and and after the pilgrimages in Indonesia. In the prepa­ration of pilgrimages, the role of KBIH was a trainer - making candi­dates of pilgrims are more understanding and capable for practicingthe ritual. In Mecca, KBIH was not only as guider of long journey. butalso the imam of various rituals of pilgrimages. The role of KBIH hasbecome spiritual patronages ( ecclesiasticum] of pilgrims in the rest oftheir lifes

Additional file 3: of Genome analysis following a national increase in Scarlet Fever in England 2014

Table of isolate numbers per region. (DOC 44 kb

Identification and Structure-Guided Development of Pyrimidinone Based USP7 Inhibitors

Ubiquitin specific protease 7 (USP7, HAUSP) has become an attractive target in drug discovery due to the role it plays in modulating Mdm2 levels and consequently p53. Increasing interest in USP7 is emerging due to its potential involvement in oncogenic pathways as well as possible roles in both metabolic and immune disorders in addition to viral infections. Potent, novel, and selective inhibitors of USP7 have been developed using both rational and structure-guided design enabled by high-resolution cocrystallography. Initial hits were identified via fragment-based screening, scaffold-hopping, and hybridization exercises. Two distinct subseries are described along with associated structure–activity relationship trends, as are initial efforts aimed at developing compounds suitable for <i>in vivo</i> experiments. Overall, these discoveries will enable further research into the wider biological role of USP7

Exacerbation Profile and Risk Factors in a T2-Low Severe Asthma Population.

Although present in a minority of severe asthmatics, very little is known about the mechanisms underlying T2-low asthma, making it a significant unmet need in asthma research. METHODS: Exacerbation assessment was a pre-specified secondary analysis of data from a RCT comparing the use of biomarkers & symptoms to adjust steroid treatment in a T2-low severe asthma-enriched cohort. Participants were phenotyped as T2LOW(fractional exhaled nitric oxide [FeNO] ≤20 ppb & blood eosinophil count [PBE] ≤150 cells/µL) or T2HIGH ( FeNO>20 or PBE>150) at study enrolment & at each exacerbation. We report comparison of exacerbators & non-exacerbators, physiological changes at exacerbation in T2LOW & T2HIGH ,& stability of inflammatory phenotypes. RESULTS: 60.8% (183/301) ≥1 self-reported exacerbations (total of 390). Exacerbators were more likely to be female, have a higher BMI & more exacerbations requiring oral corticosteroid (OCS) & unscheduled primary care attendances for exacerbations. At enrolment, 23.6% (71/301) were T2LOW, & 76.4% (230/301) T2HIGH. The T2LOW group had more asthma primary care attendances, were more likely to have a previous admission to HDU/ICU & to be receiving maintenance OCS. At exacerbation the T2LOW events were indistinguishable from T2HIGH exacerbations in terms of lung function & symptom increase, with no increase in T2 biomarkers from stable to exacerbation state in the T2LOW exacerbations. CONCLUSION: Asthma exacerbations demonstrating a T2LOW phenotype were physiologically & symptomatically similar to T2HIGHexacerbations. The clinically significant T2LOW exacerbations highlights the unmet & pressing need to further understand the mechanisms at play in non-T2 asthma.</p