How Not to Get the Word on Architecture: The Effect of Heidegger\u27s Prose on Norberg-Schulz\u27s Theories

In the last fifteen years, several notable architectural critics and historians have turned to the work of Martin Heidegger, especially to his essay, Building Dwelling Thinking

Revisiting Implicit Differentiation for Learning Problems in Optimal Control

This paper proposes a new method for differentiating through optimal trajectories arising from non-convex, constrained discrete-time optimal control (COC) problems using the implicit function theorem (IFT). Previous works solve a differential Karush-Kuhn-Tucker (KKT) system for the trajectory derivative, and achieve this efficiently by solving an auxiliary Linear Quadratic Regulator (LQR) problem. In contrast, we directly evaluate the matrix equations which arise from applying variable elimination on the Lagrange multiplier terms in the (differential) KKT system. By appropriately accounting for the structure of the terms within the resulting equations, we show that the trajectory derivatives scale linearly with the number of timesteps. Furthermore, our approach allows for easy parallelization, significantly improved scalability with model size, direct computation of vector-Jacobian products and improved numerical stability compared to prior works. As an additional contribution, we unify prior works, addressing claims that computing trajectory derivatives using IFT scales quadratically with the number of timesteps. We evaluate our method on a both synthetic benchmark and four challenging, learning from demonstration benchmarks including a 6-DoF maneuvering quadrotor and 6-DoF rocket powered landing.Comment: Accepted to NeurIPS 2023 (poster

CALL教室でのオーラル・コミュニケーション教育（要旨）

利用者の声CALLシステム授業担当教官の

Particulate matter components and subclinical atherosclerosis: common approaches to estimating exposure in a Multi-Ethnic Study of Atherosclerosis cross-sectional study

Abstract Background Concentrations of outdoor fine particulate matter (PM2.5) have been associated with cardiovascular disease. PM2.5 chemical composition may be responsible for effects of exposure to PM2.5. Methods Using data from the Multi-Ethnic Study of Atherosclerosis (MESA) collected in 2000–2002 on 6,256 US adults without clinical cardiovascular disease in six U.S. metropolitan areas, we investigated cross-sectional associations of estimated long-term exposure to total PM2.5 mass and PM2.5 components (elemental carbon [EC], organic carbon [OC], silicon and sulfur) with measures of subclinical atherosclerosis (coronary artery calcium [CAC] and right common carotid intima-media thickness [CIMT]). Community monitors deployed for this study from 2007 to 2008 were used to estimate exposures at baseline addresses using three commonly-used approaches: (1) nearest monitor (the primary approach), (2) inverse-distance monitor weighting and (3) city-wide average. Results Using the exposure estimate based on nearest monitor, in single-pollutant models, increased OC (effect estimate [95% CI] per IQR: 35.1 μm [26.8, 43.3]), EC (9.6 μm [3.6,15.7]), sulfur (22.7 μm [15.0,30.4]) and total PM2.5 (14.7 μm [9.0,20.5]) but not silicon (5.2 μm [−9.8,20.1]), were associated with increased CIMT; in two-pollutant models, only the association with OC was robust to control for the other pollutants. Findings were generally consistent across the three exposure estimation approaches. None of the PM measures were positively associated with either the presence or extent of CAC. In sensitivity analyses, effect estimates for OC and silicon were particularly sensitive to control for metropolitan area. Conclusion Employing commonly-used exposure estimation approaches, all of the PM2.5 components considered, except silicon, were associated with increased CIMT, with the evidence being strongest for OC; no component was associated with increased CAC. PM2.5 chemical components, or other features of the sources that produced them, may be important in determining the effect of PM exposure on atherosclerosis. These cross-sectional findings await confirmation in future work employing longitudinal outcome measures and using more sophisticated approaches to estimating exposure.http://deepblue.lib.umich.edu/bitstream/2027.42/112668/1/12940_2013_Article_651.pd

Pulmonary arterial pressures, arterial blood-gas tensions, and serum biochemistry of beef calves born and raised at high altitude

Includes bibliographical references (page 8).High-altitude exposure is physiologically challenging. This is particularly true for animals native to low-altitude environments, such as British breeds of cattle. The objective of this study was to document the effect of high altitude on select physiological parameters of healthy beef calves (Bos taurus) born and raised on a high-altitude ranch typical of the Rocky Mountain region. Pulmonary arterial pressures, arterial blood-gas tensions, serum biochemistry, and hematocrit were evaluated. The calves studied were a composite of British (50%-75%) and Continental (25-50%) breeds born on one ranch at an altitude of 2410 m. Calves were sampled at an altitude of 2410 m when 1 month old and again at an altitude of 2730 m when 3 and 6 months old. Between 3 and 6 months of age, calves had access to grazing from 2730 m to approximately 3500 m above sea level. On each occasion, 16 to 50 calves were sampled. Only calves that remained healthy throughout all three testing periods were included in the dataset. Calves with the highest pulmonary arterial pressures at 1 month of age tended to have the highest pressures at 6 months of age (r = 0.43, P = 0.16, n = 12). Respiratory alkalosis was greatest at 6 months of age (pH 7.48 ± 0.06). Mean alveolar-arterial oxygen pressure gradients were 11.7and 11.6 mmHg at 3 and 6 months of age, indicating poor transfer of oxygen from the alveoli into the pulmonary blood. Median values for blood lactate ranged from 1.4 to 3.4 mmol/L indicating substantial anaerobic respiration at all ages. Mean hematocrits were ≤ 35.7%, only slightly higher than values obtained from age-matched calves at sea level. These results suggest that the provision of oxygen to the peripheral tissues of beef calves may be compromised at altitudes over 2410 m. This may have implications for diseases of the cardiopulmonary system.Published with support from the Colorado State University Libraries Open Access Research and Scholarship Fund

Dispersion interaction between crossed conducting wires

We compute the $T=0K$ Van der Waals (nonretarded Casimir) interaction energy $E$ between two infinitely long, crossed conducting wires separated by a minimum distance $D$ much greater than their radius. We find that, up to a logarithmic correction factor, $E\propto -D^{-1}| \sin \theta | ^{-1}f(\theta)$ where $f(\theta)$ is a smooth bounded function of the angle $\theta$ between the wires. We recover a conventional result of the form $E\propto -D^{-4}|\sin\theta | ^{-1}g(\theta)$ when we include an electronic energy gap in our calculation. Our prediction of gap-dependent energetics may be observable experimentally for carbon nanotubes, either via AFM detection of the vdW force or torque, or indirectly via observation of mechanical oscillations. This shows that strictly parallel wires, as assumed in previous predictions, are not needed to see a novel effect of this type.Comment: 4 pp, 1 fig, 1 tabl

SEGUE-2 Limits on Metal-Rich Old-Population Hypervelocity Stars In the Galactic Halo

We present new limits on the ejection of metal-rich old-population hypervelocity stars from the Galactic center (GC) as probed by the SEGUE-2 survey. Our limits are a factor of 3-10 more stringent than previously reported, depending on stellar type. Compared to the known population of B-star ejectees, there can be no more than 30 times more metal-rich old-population F/G stars ejected from the GC. Because B stars comprise a tiny fraction of a normal stellar population, this places significant limits on a combination of the GC mass function and the ejection mechanism for hypervelocity stars. In the presence of a normal GC mass function, our results require an ejection mechanism that is about 5.5 times more efficient at ejecting B-stars compared to low-mass F/G stars.Comment: 18 pages including 5 figures; Submitted to Ap

Old-Population Hypervelocity Stars from the Galactic Center: Limits from the SDSS

We present limits on the ejection of old-population HVS from a sample of over 290,000 stars selected from the SDSS. We derive the speed at the solar circle from the measured positions and radial velocities by assuming a radial orbit and adopting a simple isothermal model of the Galactic halo, which enables us to identify candidate bound and unbound ejectees. We find 4 candidate bound F-stars from this sample, all with negative Galactocentric radial velocity (i.e., returning toward the GC). We additionally find 2 candidate unbound stars (one F and one G), however, existing proper motion measurements make these unlikely to be emerging from the GC. These data place an upper limit on the rate of ejection of old-population stars from the GC of ~45/Myr. Comparing to the rate for more massive B-star ejectees of ~0.5/Myr, our limit on the rate of ejection of old-population HVS shows that the mass function at the GC is not bottom-heavy and is consistent with being normal. Future targeted surveys of old-population HVS could determine if it is indeed top-heavy.Comment: Submitted to ApJ; 14 pages including 2 figure

Anaplastic Lymphoma Kinase Spares Organ Growth during Nutrient Restriction in Drosophila

SummaryDeveloping animals survive periods of starvation by protecting the growth of critical organs at the expense of other tissues. Here, we use Drosophila to explore the as yet unknown mechanisms regulating this privileged tissue growth. As in mammals, we observe in Drosophila that the CNS is more highly spared than other tissues during nutrient restriction (NR). We demonstrate that anaplastic lymphoma kinase (Alk) efficiently protects neural progenitor (neuroblast) growth against reductions in amino acids and insulin-like peptides during NR via two mechanisms. First, Alk suppresses the growth requirement for amino acid sensing via Slimfast/Rheb/TOR complex 1. And second, Alk, rather than insulin-like receptor, primarily activates PI3-kinase. Alk maintains PI3-kinase signaling during NR as its ligand, Jelly belly (Jeb), is constitutively expressed from a glial cell niche surrounding neuroblasts. Together, these findings identify a brain-sparing mechanism that shares some regulatory features with the starvation-resistant growth programs of mammalian tumors.PaperCli

GABAB receptor-mediated activation of astrocytes by gamma-hydroxybutyric acid

The gamma-aminobutyric acid (GABA) metabolite gamma-hydroxybutyric acid (GHB) shows a variety of behavioural effects when administered to animals and humans, including reward/addiction properties and absence seizures. At the cellular level, these actions of GHB are mediated by activation of neuronal GABAB receptors (GABABRs) where it acts as a weak agonist. Because astrocytes respond to endogenous and exogenously applied GABA by activation of both GABAA and GABABRs, here we investigated the action of GHB on astrocytes on the ventral tegmental area (VTA) and the ventrobasal (VB) thalamic nucleus, two brain areas involved in the reward and proepileptic action of GHB, respectively, and compared it with that of the potent GABABR agonist baclofen. We found that GHB and baclofen elicited dose-dependent (ED50: 1.6 mM and 1.3 µM, respectively) transient increases in intracellular Ca2+ in VTA and VB astrocytes of young mice and rats, which were accounted for by activation of their GABABRs and mediated by Ca2+ release from intracellular store release. In contrast, prolonged GHB and baclofen exposure caused a reduction in spontaneous astrocyte activity and glutamate release from VTA astrocytes. These findings have key (patho)physiological implications for our understanding of the addictive and proepileptic actions of GHB