Protein Crystal Growth Apparatus for Microgravity

Apparatus for growing protein crystals under microgravity environment includes a plurality of protein growth assemblies stacked one above the other within a canister. Each of the protein growth assemblies includes a tray having a number of spaced apart growth chambers recessed below an upper surface. the growth chambers each having an upstanding pedestal and an annular reservoir about the pedestal for receiving a wick and precipitating agents. A well is recessed below the top of each pedestal to define a protein crystal growth receptacle. A flexible membrane is positioned on the upper surface of each tray and a sealing plate is positioned above each membrane, each sealing plate having a number of bumpers corresponding in number and alignment to the pedestals for forcing the membrane selectively against the upper end of the respective pedestal to seal the reservoir and the receptacle when the sealing plate is forced down

Distribution of Non-uniform Demagnetization Fields in Paramagnetic Bulk Solids

A general calculation for the distribution of non-uniform demagnetization fields in paramagnetic bulk solids is described and the fields for various sample geometries are calculated. Cones, ellipsoids, paraboloids and hyperboloids with similar sample aspect ratios are considered. Significant differences in their demagnetization fields are observed. The calculation shows that the demagnetization field magnitudes decrease along the axis of symmetry (along $z$) where an externally applied magnetic field is aligned, and increase in the vicinity of the lateral surfaces with the largest field values found in the cone and the narrowest field distributions found in the hyperboloid. Application is made to the theoretical modeling of the $^{1}$H-NMR spectra of a single crystal of field-induced superconductor $\lambda$-(BETS)$_{2}$FeCl$_{4}$ with a rectangular sample geometry, providing a good fit to the measured NMR spectra. This calculation is also applicable to diamagnetic or ferromagnetic materials in general.Comment: 7 pages, 7 figures, submitted to Physical Review B (Corresponding author: [email protected]

Use of Bridges as Day Roosts by Bats in Southern Illinois

From May through July 2001, and June through August 2002 we surveyed 232 bridges in 9 southern Illinois counties for the presence of roosting bats. Fifteen bridges (6.5%) had bats roosting at the time they were surveyed. We encountered big brown bats (Eptesicus fuscus) most frequently. Eastern pipestrelles (Pipestrellus subflavus), little brown bats (Myotis lucifugus), and northern long-eared bats (M. septentrionalis) also were found roosting under bridges. The number of bats per bridge ranged from 1 to \u3e100. Bats occurred in four of the five types of bridge designs surveyed. Of the 15 bridges with bats, 11 were rechecked at a later date to determine continuity of use. Seven of the 11 (63.6%) were being used by bats when rechecked. From this, we derived an estimated usage rate of 23.6 bridges (15/0.636) during the study, or about 10% of the 232 bridges surveyed. We could not determine relationships between bat presence and habitat features around bridges

Multiple Captures of White-footed Mice (Peromyscus leucopus): Evidence for Social Structure?

Multiple captures (34 double, 6 triple) in standard Sherman live traps accounted for 6.3% of 1355 captures of Peromyscus leucopus (white-footed mice) in forested habitat in southern Illinois, from Oct. 2004 through Oct. 2005. There was a significant positive relationship between both the number and the proportion of multiple captures and estimated monthly population size. Multiple captures were all intraspecific and occurred significantly more often from Nov. through Mar. when animals were not reproductively active, but this was confounded by seasonal changes in abundance. Age/gender distribution of animals in double captures did not differ from that expected from random pairing. We suggest that sociality and synchronous entry of two white-footed mice into traps were the primary determinants of double captures; sensitivity of traps may have been the primary factor in triple capture

The First Record of the Eastern Smallfooted Myotis (\u3ci\u3eMyotis leibii\u3c/i\u3e) in Illinois

The eastern small-footed myotis (Myotis leibii) is one of the least known bats in eastern North America. We document the first record of the species in Illinois, and discuss possible reasons it has not been reported in the state until now

A report card approach to describe temporal and spatial trends in parameters for coastal seagrass habitats

Report cards that are designed to monitor environmental trends have the potential to provide a powerful communication tool because they are easy to understand and accessible to the general public, scientists, managers and policy makers. Given this functionality, they are increasingly popular in marine ecosystem reporting. We describe a report card method for seagrass that incorporates spatial and temporal variability in three metrics—meadow area, species and biomass—developed using long-term (greater than 10 years) monitoring data. This framework summarises large amounts of spatially and temporally complex data to give a numeric score that provides reliable comparisons of seagrass condition in both persistent and naturally variable meadows. We provide an example of how this is applied to seagrass meadows in an industrial port in the Great Barrier Reef World Heritage Area of north-eastern Australia

The cost effectiveness of bevacizumab when added to capecitabine, with or without mitomycin-C, in first line treatment of metastatic colorectal cancer: results from the Australasian phase III MAX study

Background: Based on the clinical data, bevacizumab has been approved in Australia and globally for the treatment of advanced colorectal cancer. However, limited evidence exists for its cost-effectiveness. The purpose of this study was to evaluate the cost effectiveness of adding bevacizumab to capecitabine monotherapy in patients with metastatic colorectal cancer, using data from the prospective economic evaluation conducted alongside the MAX trial. Methods: Individual patient level data on resource use and progression free survival were prospectively collected in the phase III MAX trial. Resource use data were collected for the period between randomisation and disease progression, and unit costs were assigned from the perspective of the Australian health care funder. Effectiveness was measured in quality adjusted progression free survival years, with utility scores obtained from both the community valued EQ-5D questionnaire and the patient valued UBQ-C questionnaire. Progression free survival was used as a secondary effectiveness measure. Results: The addition of bevacizumab to capecitabine monotherapy cost approximately $192,156 (95$135,619 to $326,894) per quality adjusted progression free survival year gained when using publicly listed pharmaceutical prices and utility values from the EQ-5D questionnaire. This decreased to$149,455 (95% CI, $100,356 to$245,910) when values from the UBQ-C questionnaire were applied. The incremental cost per progression free survival year was $145,059 (95$106,703 to $233,225). Conclusions: Bevacizumab was not found to be cost effective at its listed price, based on results from the MAX trial.Roche Products Pty Lt

The cost effectiveness of bevacizumab when added to capecitabine, with or without mitomycin-C, in first line treatment of metastatic colorectal cancer: results from the Australasian phase III MAX study

Background: Based on the clinical data, bevacizumab has been approved in Australia and globally for the treatment of advanced colorectal cancer. However, limited evidence exists for its cost-effectiveness. The purpose of this study was to evaluate the cost effectiveness of adding bevacizumab to capecitabine monotherapy in patients with metastatic colorectal cancer, using data from the prospective economic evaluation conducted alongside the MAX trial. Methods: Individual patient level data on resource use and progression free survival were prospectively collected in the phase III MAX trial. Resource use data were collected for the period between randomisation and disease progression, and unit costs were assigned from the perspective of the Australian health care funder. Effectiveness was measured in quality adjusted progression free survival years, with utility scores obtained from both the community valued EQ-5D questionnaire and the patient valued UBQ-C questionnaire. Progression free survival was used as a secondary effectiveness measure. Results: The addition of bevacizumab to capecitabine monotherapy cost approximately $192,156 (95$135,619 to $326,894) per quality adjusted progression free survival year gained when using publicly listed pharmaceutical prices and utility values from the EQ-5D questionnaire. This decreased to$149,455 (95% CI, $100,356 to$245,910) when values from the UBQ-C questionnaire were applied. The incremental cost per progression free survival year was $145,059 (95$106,703 to $233,225). Conclusions: Bevacizumab was not found to be cost effective at its listed price, based on results from the MAX trial.Roche Products Pty Lt

Hipparcos period-luminosity relations for Miras and semiregular variables

We present period-luminosity diagrams for nearby Miras and semiregulars, selecting stars with parallaxes better than 20 per cent and well-determined periods. Using K-band magnitudes, we find two well-defined P-L sequences, one corresponding to the standard Mira P-L relation and the second shifted to shorter periods by a factor of about 1.9. The second sequence only contains semiregular variables, while the Mira sequence contains both Miras and semiregulars. Several semiregular stars show double periods in agreement with both relations. The Whitelock evolutionary track is shown to fit the data, indicating that the semiregulars are Mira progenitors. The transition between the two sequences may correspond to a change in pulsation mode or to a change in the stellar structure. Large amplitude pulsations leading to classical Mira classification occur mainly near the tip of the local AGB luminosity function.Comment: 10 pages with figures, accepted by ApJ Letter