Social change, social capital, and civic community: a qualitative study of the long-term effects of industrial restructuring on a coastal community

This dissertation examines the link between economic restructuring and patterns of social capital and social control. Although social capital literature frequently examines the consequences of social capital on a variety of outcomes, the key theoretical contribution of my dissertation is a framework to explain how community structure conditions social relations among local residents. Specifically, I examine the effects of changes in economic structure on social capital. Using nine South Louisiana community case studies, I evaluate the effect of restructuring in the offshore oil industry on the development of weak ties among local residents. My central finding is that population turnover and the in-migration of workers demanded by a rapidly expanding economy enhances the density of weak tie networks within the community. This is important because weak ties have been shown to have negative impacts on crime since they serve as a foundation for exerting social control over community members engaging in collective problem solving activity. My research underscores how growing communities can better accommodate a growing population. I demonstrate that the presence of voluntary associations (Rotary, Lion’s, and Elk’s Clubs) help integrate newcomers and mitigate the negative effects of population turnover. This is in sharp contrast to social disorganization theory that posits a negative effect of population change whereby in-migration dilutes ties among community members and results in higher rates of criminal activity

A Reference-Free Algorithm for Computational Normalization of Shotgun Sequencing Data

Deep shotgun sequencing and analysis of genomes, transcriptomes, amplified single-cell genomes, and metagenomes has enabled investigation of a wide range of organisms and ecosystems. However, sampling variation in short-read data sets and high sequencing error rates of modern sequencers present many new computational challenges in data interpretation. These challenges have led to the development of new classes of mapping tools and {\em de novo} assemblers. These algorithms are challenged by the continued improvement in sequencing throughput. We here describe digital normalization, a single-pass computational algorithm that systematizes coverage in shotgun sequencing data sets, thereby decreasing sampling variation, discarding redundant data, and removing the majority of errors. Digital normalization substantially reduces the size of shotgun data sets and decreases the memory and time requirements for {\em de novo} sequence assembly, all without significantly impacting content of the generated contigs. We apply digital normalization to the assembly of microbial genomic data, amplified single-cell genomic data, and transcriptomic data. Our implementation is freely available for use and modification

The promise of next generation colloids

The aim of perioperative haemodilution is to reduce loss of red blood cells during elective surgery. The oncotic and molecular characteristics of the various plasma substitutes employed determine how effectively normovolaemia is maintained, and their non-oncotic effects include alterations in microvascular perfusion. In the previous issue of Critical Care, Martini and colleagues assessed the effects of haemodilution with either polyethylene glycol (PEG)ylated albumin or a commercially available hydroxyethyl starch-based colloid in a hamster haemorrhage model. PEGylated albumin was superior to hydroxyethyl starch, as reflected by survival, haemodynamic parameters and assessment of the microcirculation using intravital microscopy

Three-Dimensional Magnetohydrodynamics Simulations Of Counter-Helicity Spheromak Merging In The Swarthmore Spheromak Experiment

Recent counter-helicity spheromak merging experiments in the Swarthmore Spheromak Experiment (SSX) have produced a novel compact torus (CT) with unusual features. These include a persistent antisymmetric toroidal magnetic field profile and a slow, nonlinear emergence of the n = 1 tilt mode. Experimental measurements are inconclusive as to whether this unique CT is a fully merged field-reversed configuration (FRC) with strong toroidal field or a partially merged doublet CT configuration with both spheromak- and FRC-like characteristics. In this paper, the SSX merging process is studied in detail using three-dimensional resistive MHD simulations from the Hybrid Magnetohydrodynamics (HYM) code. These simulations show that merging plasmas in the SSX parameter regime only partially reconnect, leaving behind a doublet CT rather than an FRC. Through direct comparisons, we show that the magnetic structure in the simulations is highly consistent with the SSX experimental observations. We also find that the n = 1 tilt mode begins as a fast growing linear mode that evolves into a slower-growing nonlinear mode before being detected experimentally. A simulation parameter scan over resistivity, viscosity, and line-tying shows that these parameters can strongly affect the behavior of both the merging process and the tilt mode. In fact, merging in certain parameter regimes is found to produce a toroidal-field-free FRC rather than a doublet CT. (C) 2011 American Institute of Physics. [doi:10.1063/1.3660533

Scots-Irish Women and the Southern Culture of Violence: The Influence of Scots-Irish Females on High Rates of Southern Violence

Prior research has documented a higher rate of violent crime within the South relative to other U.S. regions. Some scholars argue that higher rates of violence in the South are due to the lasting effect of the unique culture of the Scots-Irish immigrants that came into the U.S. in the mid-1700\u27s. Though there is a large body of literature examining the link between culture and violence in the South, an implicit assumption of this line of study is that the cultural effect occurs largely within the white male population in rural Southern areas. No study, to our knowledge, has extended this thesis to females. We address this omission in prior analyses by empirically testing the Southern Culture of Violence thesis using female arrest rates. Drawing on countylevel ancestry data from the 2000 Census and UCR Supplementary Homicide Report data, we estimate a series of negative binomial regression models. A conclusion and discussion of the results follow

Chronic Environmental Stress and the Temporal Course of Depression and Panic Disorder: A Trait-State-Occasion Modeling Approach

Both acute stressful life events and ongoing strains are thought to confer vulnerability to emotional disorders. Unremitting stressful conditions may be particularly pathogenic, but prior research has struggled to delimit chronic versus transient stressful experiences. We aimed to isolate stable stressors-theorized to be indicators of a latent stress proneness trait-and to examine their effects on the temporal course of depression and panic disorder. We recruited 677 patients diagnosed with an emotional disorder and administered interviews for psychopathology and life stress 3 times over 12-month intervals. Trait-state-occasion modeling revealed that 74% of the variance in life stress was stable over the follow-up period. These stable stressors were associated with a more refractory course of depression and, to a smaller degree, panic disorder over time. In addition, neither gender nor participation in cognitive-behavioral therapy affected the persistence of environmental stress over the study time frame. We discuss implications of these findings for explaining depression recurrence, improving psychological interventions for emotional disorders, and the measurement and evaluation of stress proneness

Bench-to-bedside review: Inhaled nitric oxide therapy in adults

Nitric oxide (NO) is an endogenous mediator of vascular tone and host defence. Inhaled nitric oxide (iNO) results in preferential pulmonary vasodilatation and lowers pulmonary vascular resistance. The route of administration delivers NO selectively to ventilated lung units so that its effect augments that of hypoxic pulmonary vasoconstriction and improves oxygenation. This 'Bench-to-bedside' review focuses on the mechanisms of action of iNO and its clinical applications, with emphasis on acute lung injury and the acute respiratory distress syndrome. Developments in our understanding of the cellular and molecular actions of NO may help to explain the hitherto disappointing results of randomised controlled trials of iNO