The construction of viewpoint aspect: the imperfective revisited

This paper argues for a constructionist approach to viewpoint Aspect by exploring the idea that it does not exert any altering force on the situation-aspect properties of predicates. The proposal is developed by analyzing the syntax and semantics of the imperfective, which has been attributed a coercer role in the literature as a de-telicizer and de-stativizer in the progressive, and as a de-eventivizer in the so-called ability (or attitudinal) and habitual readings. This paper proposes a unified semantics for the imperfective, preserving the properties of eventualities throughout the derivation. The paper argues that the semantics of viewpoint aspect is encoded in a series of functional heads containing interval-ordering predicates and quantifiers. This richer structure allows us to account for a greater amount of phenomena, such as the perfective nature of the individual instantiations of the event within a habitual construction or the nonculminating reading of perfective accomplishments in Spanish. This paper hypothesizes that nonculminating accomplishments have an underlying structure corresponding to the perfective progressive. As a consequence, the progressive becomes disentangled from imperfectivity and is given a novel analysis. The proposed syntax is argued to have a corresponding explicit morphology in languages such as Spanish and a nondifferentiating one in languages such as English; however, the syntax-semantics underlying both of these languages is argued to be the same

Operational Aspects of CASA UNO \u2788-the First Large Scale International GPS Geodetic Network

For three weeks, from January 18 to February 5, 1988, scientists and engineers from 13 countries and 30 international agencies and institutions cooperated in the most extensive GPS (Global Positioning System) field campaign, and the largest geodynamics experiment, in the world to date. This collaborative experiment concentrated GPS receivers in Central and South America. the predicted rates of motions are on the order of 5-10 cm/yr. Global coverage of GPS observations spanned 220 degrees of longitude and 125 degrees of latitude using a total of 43 GPS receivers. The experiment was the first civilian effort at implementing an extended international GPS satellite tracking network. Covariance analyses incorporating the extended tracking network predicted significant improvement in precise orbit determination, allowing accurate long-baseline geodesy in the science areas

The Perfective, the Progressive and the (dis)closure of situations: comment on the paper by María J. Arche

In the present paper, inspired by María J. Arche’s work, “The construction of viewpoint aspect: the imperfective revisited” (2013, this issue), I add several pieces of evidence in favor of her proposal that viewpoint aspect does not alter the fundamental situation aspect properties of predicates. Namely, I discuss the temporal interpretations in Capeverdean, a Portuguese-based Creole language for which the salient opposition in the domain of viewpoint aspect is not between the imperfective and the perfective, but rather between the Progressive and the Perfect, here taken as semantically complex categories that involve certain temporal characteristics; crucially, imperfectivity is one of the features of the Progressive and a perfective viewpoint is part of the semantic complexity of the Perfect. I also discuss the role of for-time durational adverbials when combined with the perfective and propose that, in their presence, the relevant final boundary when telic predicates are at stake is not the culmination of the event, but rather the final point described by that time-argument. This proposal accounts nicely for the fact that, in these specific contexts, there is no contradiction in having this perfective clause conjoined with the assertion that the underlying telic situation is not completed.info:eu-repo/semantics/publishedVersio

IGFBP-1 expression is reduced in human type 2 diabetic glomeruli and modulates β1-integrin/FAK signalling in human podocytes

AIMS/HYPOTHESIS: Podocyte loss or injury is one of the earliest features observed in the pathogenesis of diabetic kidney disease (DKD), which is the leading cause of end-stage renal failure worldwide. Dysfunction in the IGF axis, including in IGF binding proteins (IGFBPs), is associated with DKD, particularly in the early stages of disease progression. The aim of this study was to investigate the potential roles of IGFBPs in the development of type 2 DKD, focusing on podocytes. METHODS: IGFBP expression was analysed in the Pima DKD cohort, alongside data from the Nephroseq database, and in ex vivo human glomeruli. Conditionally immortalised human podocytes and glomerular endothelial cells were studied in vitro, where IGFBP-1 expression was analysed using quantitative PCR and ELISAs. Cell responses to IGFBPs were investigated using migration, cell survival and adhesion assays; electrical cell-substrate impedance sensing; western blotting; and high-content automated imaging. RESULTS: Data from the Pima DKD cohort and from the Nephroseq database demonstrated a significant reduction in glomerular IGFBP-1 in the early stages of human type 2 DKD. In the glomerulus, IGFBP-1 was predominantly expressed in podocytes and controlled by phosphoinositide 3-kinase (PI3K)–forkhead box O1 (FoxO1) activity. In vitro, IGFBP-1 signalled to podocytes via β1-integrins, resulting in increased phosphorylation of focal-adhesion kinase (FAK), increasing podocyte motility, adhesion, electrical resistance across the adhesive cell layer and cell viability. CONCLUSIONS/INTERPRETATION: This work identifies a novel role for IGFBP-1 in the regulation of podocyte function and that the glomerular expression of IGFBP-1 is reduced in the early stages of type 2 DKD, via reduced FoxO1 activity. Thus, we hypothesise that strategies to maintain glomerular IGFBP-1 levels may be beneficial in maintaining podocyte function early in DKD. GRAPHICAL ABSTRACT: [Image: see text] SUPPLEMENTARY INFORMATION: The online version contains peer-reviewed but unedited supplementary material available at 10.1007/s00125-021-05427-1

A evolução da noção de parâmetros The evolution of the notion of parameter

Este trabalho apresenta uma retrospectiva do conceito de parâmetro na teoria de Princípios e Parâmetros e mostra que: a) no primeiro estágio da teoria, os parâmetros eram concebidos como propriedades associadas a Princípios e b) no segundo estágio, como propriedades do léxico, mais especificamente do léxico funcional.. Essa segunda visão também sofreu uma evolução, de um conceito substantivo, para um conceito formal de classes funcionais. O trabalho discute ainda a noção de parâmetros associados a diferentes níveis de representação.<br>This paper presents an overview of the concept of parameter in the Principles and Parameters theory, showing that a) in the first stage parameters were conceived as variation associated to the Principles and b) in the second stage as properties of the lexicon, and more specifically as properties of functional categories. The latter view has also developed from a substantive conception of functional categories to a more formal abstract characterization of functional heads. The paper also discusses parameters related to different levels of representation